| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hosseinkhani M et al. | Trichostatin A induces myocardial differentiation of monkey ES cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17368572 |
| Kim HJ et al. | Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371805 |
| Kitamura H et al. | Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. | 2007 | J. Urol. | pmid:17574613 |
| Kishigami S et al. | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. | 2007 | J. Reprod. Dev. | pmid:17077581 |
| Rigamonti D et al. | Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators. | 2007 | J. Biol. Chem. | pmid:17565993 |
| Huang JC et al. | Changes in histone acetylation during postovulatory aging of mouse oocyte. | 2007 | Biol. Reprod. | pmid:17582009 |
| Lee S et al. | Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17588744 |
| Castro-Galache MD et al. | Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells. | 2007 | Int. J. Biochem. Cell Biol. | pmid:17588800 |
| Nagashima T et al. | Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis. | 2007 | Mol. Hum. Reprod. | pmid:17267518 |
| Sakuma M et al. | Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. | 2007 | Cancer Sci. | pmid:17270028 |
| Kim SH et al. | Regulation of the HIF-1alpha stability by histone deacetylases. | 2007 | Oncol. Rep. | pmid:17273746 |
| Ou JN et al. | Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. | 2007 | Biochem. Pharmacol. | pmid:17276411 |
| Hatjiharissi E et al. | Proteomic analysis of waldenstrom macroglobulinemia. | 2007 | Cancer Res. | pmid:17440091 |
| Liu TX et al. | Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. | 2007 | Nat. Med. | pmid:17159988 |
| Cecconi D et al. | Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. | 2007 | Proteomics | pmid:17443844 |
| Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
| Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
| Hellebrekers DM et al. | Identification of epigenetically silenced genes in tumor endothelial cells. | 2007 | Cancer Res. | pmid:17483324 |
| Yi T et al. | Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. | 2007 | Exp. Mol. Med. | pmid:17464183 |
| Long JE and Cai X | Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. | 2007 | Gene | pmid:17150312 |
| Wong CM et al. | Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. | 2007 | Hepatology | pmid:17464989 |
| Berg T et al. | Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. | 2007 | Leuk. Res. | pmid:17056112 |
| Bu Y and Gelman IH | v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. | 2007 | J. Biol. Chem. | pmid:17626016 |
| Dombrowsky H and Uhlig S | Steroids and histone deacetylase in ventilation-induced gene transcription. | 2007 | Eur. Respir. J. | pmid:17626110 |
| Zampetaki A et al. | Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17626239 |
| Strobl JS et al. | Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. | 2007 | J. Parasitol. | pmid:17626366 |
| Ho AK et al. | Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. | 2007 | Endocrinology | pmid:17628002 |
| Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17679169 |
| Sun DF et al. | [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. | 2007 | Zhonghua Yi Xue Yi Chuan Xue Za Zhi | pmid:17680526 |
| Peng Y et al. | The histone deacetylase inhibitor sodium butyrate inhibits baculovirus-mediated transgene expression in Sf9 cells. | 2007 | J. Biotechnol. | pmid:17655959 |
| Li YL et al. | [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. | 2007 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:17659468 |
| Wu Y et al. | The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. | 2007 | Genes Cells | pmid:17663720 |
| Schneider G et al. | HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. | 2007 | Cell Prolif. | pmid:17635519 |
| Bode KA et al. | Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. | 2007 | Immunology | pmid:17635610 |
| Tomita A et al. | Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy. | 2007 | Int. J. Hematol. | pmid:17675267 |
| Wang J et al. | Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. | 2007 | J. Biol. Chem. | pmid:17675290 |
| Di Renzo F et al. | Boric acid inhibits embryonic histone deacetylases: a suggested mechanism to explain boric acid-related teratogenicity. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17320131 |
| Xin C et al. | FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. | 2007 | Br. J. Pharmacol. | pmid:17325654 |
| Hishiki T et al. | BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3. | 2007 | J. Biol. Chem. | pmid:17644518 |
| Wu Y et al. | Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. | 2007 | Reprod Sci | pmid:17644810 |
| Wang CT and Meng M | [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17650409 |
| Janowski BA et al. | Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. | 2007 | Nat. Chem. Biol. | pmid:17259978 |
| Oyama T et al. | Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. | 2007 | J. Cell Biol. | pmid:17261849 |
| Zhang L et al. | Small molecule regulators of autophagy identified by an image-based high-throughput screen. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18024584 |
| Woo HJ et al. | Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells. | 2007 | Exp. Mol. Pathol. | pmid:16574101 |
| Park JJ et al. | Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. | 2007 | J. Gen. Virol. | pmid:18024889 |
| Moiseeva EP et al. | Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. | 2007 | Mol. Cancer Ther. | pmid:18025290 |
| Ehrenkaufer GM et al. | Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. | 2007 | BMC Genomics | pmid:17612405 |
| Putignano E et al. | Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. | 2007 | Neuron | pmid:17329213 |
| Vibhakar R et al. | Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. | 2007 | Neuro-oncology | pmid:17329407 |
| Pan L et al. | Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. | 2007 | Cancer | pmid:17330857 |
| Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
| Araki H et al. | Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. | 2007 | Blood | pmid:17185465 |
| Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
| Lee EL et al. | Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. | 2007 | J. Cell. Physiol. | pmid:17186499 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Feng W et al. | Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. | 2007 | Int. J. Cancer | pmid:17230502 |
| Karam JA et al. | The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. | 2007 | Int. J. Cancer | pmid:17230511 |
| Robertson DM et al. | Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium. | 2007 | Exp. Eye Res. | pmid:17709104 |
| Chen WY et al. | Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1). | 2007 | Mol. Cell. Biol. | pmid:17709382 |
| D'Alessio AC et al. | Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. | 2007 | Mol. Cell. Biol. | pmid:17709385 |
| Tsaprouni LG et al. | Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation. | 2007 | Clin. Exp. Immunol. | pmid:17711487 |
| Yasukawa K et al. | Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts. | 2007 | Br. J. Dermatol. | pmid:17711521 |
| Fujita Y et al. | Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. | 2007 | Dev. Cell | pmid:17199038 |
| Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
| Adcock IM et al. | Epigenetic regulation of airway inflammation. | 2007 | Curr. Opin. Immunol. | pmid:17720468 |
| Zhang Y et al. | Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. | 2007 | Radiat. Res. | pmid:17722998 |
| Zhou X et al. | The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. | 2007 | Cancer Genet. Cytogenet. | pmid:17693185 |
| Zhong S et al. | Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. | 2007 | Oncogene | pmid:17043644 |
| Han S et al. | HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region. | 2007 | Immunol. Lett. | pmid:17270283 |
| Wang F et al. | Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. | 2007 | Biol. Reprod. | pmid:17823087 |
| Katz RA et al. | High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. | 2007 | J. Virol. | pmid:17202206 |
| De los Santos M et al. | Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. | 2007 | Mol. Cancer Ther. | pmid:17431121 |
| Qi J et al. | [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18396643 |
| Schnur N et al. | The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. | 2007 | Biochim. Biophys. Acta | pmid:17894944 |
| Oshima M et al. | Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17949687 |
| Itoh Y et al. | Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. | 2007 | J. Med. Chem. | pmid:17929798 |
| Pourebrahim R et al. | ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations. | 2007 | FEBS Lett. | pmid:17936758 |
| Sichtig N et al. | Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. | 2007 | Arch. Biochem. Biophys. | pmid:17897615 |
| Charrier C et al. | Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17897824 |
| Ondrousková E et al. | A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts. | 2007 | Leuk. Res. | pmid:16930693 |
| Li T and Chiang JY | A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. | 2007 | Gastroenterology | pmid:17920062 |
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| Qi J et al. | [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17923031 |
| Pulukuri SM et al. | Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. | 2007 | J. Biol. Chem. | pmid:17923479 |
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| Putnik J et al. | The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60. | 2007 | Biochim. Biophys. Acta | pmid:17980166 |
| Hummel M et al. | Transcriptional reactivation of murine cytomegalovirus ie gene expression by 5-aza-2'-deoxycytidine and trichostatin A in latently infected cells despite lack of methylation of the major immediate-early promoter. | 2007 | J. Gen. Virol. | pmid:17374752 |
| Kuljaca S et al. | Enhancing the anti-angiogenic action of histone deacetylase inhibitors. | 2007 | Mol. Cancer | pmid:17958916 |
| Appanah R et al. | An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. | 2007 | PLoS Genet. | pmid:17305432 |
| Bui HT et al. | Regulation of chromatin and chromosome morphology by histone H3 modifications in pig oocytes. | 2007 | Reproduction | pmid:17307905 |
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| Barr H et al. | Mbd2 contributes to DNA methylation-directed repression of the Xist gene. | 2007 | Mol. Cell. Biol. | pmid:17353271 |
| Li B et al. | FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17360565 |
| Vandergeeten C et al. | HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha + TSA. | 2007 | Biochem. Pharmacol. | pmid:17386923 |
| Rohner A et al. | Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. | 2007 | Leuk. Res. | pmid:17391757 |
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| Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |