trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Shi LH et al. Trichostatin A and nuclear reprogramming of cloned rabbit embryos. 2008 J. Anim. Sci. pmid:18245503
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Duncan HF et al. Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. 2012 J Endod pmid:22341071
Wu Y et al. Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. 2017 J Diabetes Res pmid:28191472
Marengo E et al. Use of Legendre moments for the fast comparison of two-dimensional polyacrylamide gel electrophoresis maps images. 2005 J Chromatogr A pmid:16301071
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Hutz JE et al. The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. 2013 J Biomol Screen pmid:23204073
Chen MH et al. A new trichostatin analog from Streptomyces sp. CPCC 203909. 2015 J Asian Nat Prod Res pmid:25977996
Schwechter BR et al. Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17525221
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Crosson CE et al. Inhibition of histone deacetylase protects the retina from ischemic injury. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20164449
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Wallace DM et al. Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16799012
Wang J et al. Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20089874
Xie L et al. Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition. 2014 Invest. Ophthalmol. Vis. Sci. pmid:24994865
Klisovic DD et al. Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12766035
Robertson DM et al. C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20375332
Fan J et al. Inhibition of HDAC2 protects the retina from ischemic injury. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23696608
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Sonnemann J et al. Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. 2005 Invest New Drugs pmid:15744585
Fraczek J et al. Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. 2009 Invest New Drugs pmid:18825314
Li GC et al. Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. 2006 Int. J. Urol. pmid:16771729
Sah NK et al. Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. 2006 Int. J. Radiat. Oncol. Biol. Phys. pmid:17011457
Kim JH et al. Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. 2004 Int. J. Radiat. Oncol. Biol. Phys. pmid:15234053
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Bai T et al. A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. 2006 Int. J. Oncol. pmid:16391806
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Kadaja-Saarepuu L et al. Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. 2012 Int. J. Oncol. pmid:21947346
You BR and Park WH Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. 2013 Int. J. Oncol. pmid:23165748
Gray SG et al. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. 2004 Int. J. Oncol. pmid:15010814
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Zhou C et al. Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. 2006 Int. J. Oncol. pmid:16773209
Gahr S et al. The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. 2007 Int. J. Oncol. pmid:17671683
Yee SB et al. Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. 2004 Int. J. Oncol. pmid:15492835
Al-Nakhle H et al. Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. 2013 Int. J. Oncol. pmid:24068253
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Kang KA et al. Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. 2013 Int. J. Oncol. pmid:24100442
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Imesch P et al. MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. 2009 Int. J. Oncol. pmid:19639184
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Rho JH et al. Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. 2005 Int. J. Oncol. pmid:16010429
Choi YH Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. 2005 Int. J. Oncol. pmid:16010430
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Park WH et al. Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. 2003 Int. J. Oncol. pmid:12684681
Sonnemann J et al. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. 2006 Int. J. Oncol. pmid:16465382
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Sakharkar AJ et al. Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. 2014 Int. J. Neuropsychopharmacol. pmid:24528596
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Gray SG et al. Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. 2000 Int. J. Mol. Med. pmid:10601571
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Guo Y et al. Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. 2017 Int. J. Mol. Med. pmid:28849190