trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen J et al. | Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. | 2013 | Toxicol Ind Health | pmid:22294440 |
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| Azechi T et al. | Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. | 2013 | J. Atheroscler. Thromb. | pmid:23518467 |
| Gao SM et al. | Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. | 2013 | Exp. Hematol. | pmid:23111066 |
| Piazza R et al. | Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. | 2013 | Neoplasia | pmid:23633923 |
| Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
| Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
| Li M et al. | Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23680675 |
| Algamas-Dimantov A et al. | Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. | 2013 | Cell Oncol (Dordr) | pmid:23307400 |
| Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
| Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
| Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
| Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
| Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
| Rosborough BR et al. | Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. | 2012 | J. Leukoc. Biol. | pmid:22028329 |
| Londhe P et al. | CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells. | 2012 | Int. J. Cancer | pmid:21989738 |
| Tsuboi H et al. | Epigenetic memory of DNAi associated with cytosine methylation and histone modification in fern. | 2012 | Plant Signal Behav | pmid:22990449 |
| Anh TD et al. | The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells. | 2012 | Oncol. Rep. | pmid:21993600 |
| Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
| Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
| Li H et al. | Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. | 2012 | Diabetes | pmid:22338096 |
| Duncan HF et al. | Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. | 2012 | J Endod | pmid:22341071 |
| Kohda T et al. | Gene expression profile normalization in cloned mice by trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22257163 |
| Drzewiecka H and Jagodzinski PP | Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22257695 |
| Shah S et al. | Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. | 2012 | Cancer Res. | pmid:22258452 |
| Bebenek IG et al. | CYP2S1 is negatively regulated by corticosteroids in human cell lines. | 2012 | Toxicol. Lett. | pmid:22155357 |
| Sakuma Y et al. | WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. | 2012 | Lab. Invest. | pmid:22157722 |
| Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
| Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
| Calfa G et al. | HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. | 2012 | Hippocampus | pmid:22161912 |
| Kadowaki M et al. | DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. | 2012 | Int. J. Cancer | pmid:21437897 |
| Jasek E et al. | Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells. | 2012 | Anticancer Res. | pmid:22753739 |
| Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
| Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
| Tu Z et al. | The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression. | 2012 | Mol. Cell. Biochem. | pmid:22476901 |
| Landreville S et al. | Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. | 2012 | Clin. Cancer Res. | pmid:22038994 |
| Buurman R et al. | Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. | 2012 | Gastroenterology | pmid:22641068 |
| Orlova DY et al. | Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. | 2012 | J. Cell. Biochem. | pmid:22644811 |
| Glait-Santar C et al. | Expression pattern of SVEP1 alternatively-spliced forms. | 2012 | Gene | pmid:22659106 |
| Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
| Yin Z et al. | Position effect variegation and epigenetic modification of a transgene in a pig model. | 2012 | Genet. Mol. Res. | pmid:22370938 |
| Halldórsdóttir AM et al. | Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. | 2012 | Am. J. Hematol. | pmid:22374828 |
| Pufahl L et al. | Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. | 2012 | J. Cell. Mol. Med. | pmid:21883892 |
| Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
| Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
| Zhang QC et al. | Histone deacetylase inhibitor trichostatin A enhances anti-tumor effects of docetaxel or erlotinib in A549 cell line. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22994780 |
| He M and Guo Q | [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22561570 |
| Catalano MG et al. | Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22563106 |
| Yu L et al. | Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. | 2012 | Arch. Med. Res. | pmid:22564421 |
| Bobkov DE et al. | [Isolation of tropomyosin particles from the cytosol of cultured cells and their protein composition analysis]. | 2012 | Tsitologiia | pmid:22567898 |