trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Chromosome Inversion D007446 1 associated lipids
Rhabdomyosarcoma, Embryonal D018233 1 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Rhabdoid Tumor D018335 1 associated lipids
Visceral Pain D059265 1 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Goldenhar Syndrome D006053 1 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Adenomyosis D062788 1 associated lipids
Capsule Opacification D058442 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Cystadenoma, Serous D018293 1 associated lipids
Supratentorial Neoplasms D015173 1 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Hypesthesia D006987 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Roseolovirus Infections D019349 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Rhabdomyosarcoma, Alveolar D018232 2 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Ganglioneuroma D005729 2 associated lipids
Mastocytoma D034801 3 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Osteomalacia D010018 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Genomic Instability D042822 7 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Enteritis D004751 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Keloid D007627 12 associated lipids
Cat Diseases D002371 12 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Neoplasms D009369 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Radiation Injuries D011832 14 associated lipids
Brain Neoplasms D001932 15 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Carcinoma D002277 18 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leishmaniasis D007896 19 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Translocation, Genetic D014178 20 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypersensitivity D006967 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Fibrosis D005355 23 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasal Polyps D009298 26 associated lipids
Glioblastoma D005909 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Patel V et al. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. 2009 J. Med. Chem. pmid:19317450
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Baud MG et al. Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. 2012 J. Med. Chem. pmid:22280363
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Casero RA and Woster PM Recent advances in the development of polyamine analogues as antitumor agents. 2009 J. Med. Chem. pmid:19534534
Woo SH et al. Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. 2002 J. Med. Chem. pmid:12061890
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Glenn MP et al. Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. 2004 J. Med. Chem. pmid:15163181
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Rincón-Arano H et al. YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. 2005 J. Mol. Biol. pmid:15913647
Kee HJ and Kook H Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. 2009 J. Mol. Cell. Cardiol. pmid:19729022
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Sibinga NE Stable protein, unstable plaque? 2009 J. Mol. Cell. Cardiol. pmid:19101562
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Margueron R et al. Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. 2004 J. Mol. Endocrinol. pmid:15072561
Nygård M et al. Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. 2006 J. Mol. Endocrinol. pmid:16720720
Ching LY et al. Synergistic effect of p53 on TSA-induced stanniocalcin 1 expression in human nasopharyngeal carcinoma cells, CNE2. 2012 J. Mol. Endocrinol. pmid:22493143
Jaffe RC et al. Histone deacetylase inhibition and progesterone act synergistically to stimulate baboon glycodelin gene expression. 2007 J. Mol. Endocrinol. pmid:17339403
Feng L et al. Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. 2013 J. Mol. Med. pmid:22763818
Her S et al. Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. 2010 J. Mol. Neurosci. pmid:19728174
Sharma S et al. Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. 2015 J. Mol. Neurosci. pmid:25391764
Jang BG et al. Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells. 2018 J. Mol. Neurosci. pmid:29516351
Wang Y et al. Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats. 2015 J. Mol. Neurosci. pmid:24829091
Itoh M et al. Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. 2013 J. Mol. Neurosci. pmid:22711563
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Park JW et al. Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. 2011 J. Nat. Prod. pmid:21504214
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Host L et al. Inhibition of histone deacetylases in rats self-administering cocaine regulates lissencephaly gene-1 and reelin gene expression, as revealed by microarray technique. 2010 J. Neurochem. pmid:20132486
Chen FQ et al. Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea. 2009 J. Neurochem. pmid:19141081
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Pazmany T and Tomasi TB The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. 2006 J. Neuroimmunol. pmid:16360884
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Sudo H and Baas PW Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts. 2010 J. Neurosci. pmid:20505088
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Mateen S et al. Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. 2013 J. Pharmacol. Exp. Ther. pmid:23461975
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Koriyama Y et al. Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. 2014 J. Pharmacol. Sci. pmid:24389816
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