Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Qiang M et al. | Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:25522411 |
Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
Shi QQ et al. | Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25292076 |
Wei N et al. | Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. | 2014 | Mol. Cell | pmid:25284223 |
An JH et al. | The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells. | 2014 | FEBS Lett. | pmid:25281925 |
Han RF et al. | Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. | 2014 | Mol Med Rep | pmid:25269990 |
Boucher J et al. | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246545 |
Wang BY et al. | Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. | 2014 | Pharmacol. Biochem. Behav. | pmid:25242807 |
Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
Srirattana K et al. | Effects of trichostatin A on In vitro development and DNA methylation level of the satellite I region of swamp buffalo (Bubalus bubalis) cloned embryos. | 2014 | J. Reprod. Dev. | pmid:24909601 |
Wang Y et al. | Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. | 2014 | Int. J. Mol. Med. | pmid:24888454 |
Peiffer L et al. | Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation. | 2014 | J. Cancer Res. Clin. Oncol. | pmid:24793644 |
Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
Aune SE et al. | Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24632412 |
Yuan TF et al. | The epigenetics changes in Parkinson's disease: a novel therapeutic target. | 2014 | CNS Neurosci Ther | pmid:24629108 |
Sun S et al. | Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. | 2014 | PLoS ONE | pmid:24626188 |
Saayman S et al. | An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. | 2014 | Mol. Ther. | pmid:24576854 |
McEachern LA and Murphy PR | Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus. | 2014 | Mol. Endocrinol. | pmid:24552587 |
Felisbino MB et al. | Changes in chromatin structure in NIH 3T3 cells induced by valproic acid and trichostatin A. | 2014 | J. Cell. Biochem. | pmid:24913611 |
Maleszewska M et al. | The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells. | 2014 | Pharmacol Rep | pmid:24905315 |
Fetahu IS et al. | Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. | 2014 | Int. J. Cancer | pmid:24691920 |
Saccone V et al. | HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. | 2014 | Genes Dev. | pmid:24682306 |
Alcarraz-Vizán G et al. | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. | 2014 | Biochim. Biophys. Acta | pmid:24368265 |
Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |
Guo J et al. | Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24763005 |
Blank M et al. | Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus. | 2014 | Neurobiol Learn Mem | pmid:24583371 |
Iancu-Rubin C and Hoffman R | Role of epigenetic reprogramming in hematopoietic stem cell function. | 2015 | Curr. Opin. Hematol. | pmid:26049747 |
Huisman C et al. | Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. | 2015 | Epigenetics | pmid:25830725 |
Fujii K et al. | Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. | 2015 | J. Cell. Physiol. | pmid:25820447 |
Pandey SC et al. | Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. | 2015 | Neurobiol. Dis. | pmid:25814047 |
Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
Hartman H et al. | Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. | 2015 | Dig. Dis. Sci. | pmid:25492506 |
Jiang H et al. | Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. | 2015 | Acta Histochem. | pmid:25480399 |
Du J et al. | HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. | 2015 | J. Cell. Physiol. | pmid:25475100 |
Cui Y et al. | Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. | 2015 | PLoS ONE | pmid:26710276 |
Fukui T et al. | Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. | 2015 | Toxicology | pmid:25758465 |
Wang Y et al. | Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. | 2015 | Chem. Biol. | pmid:25699604 |
Chahine MN et al. | Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. | 2015 | Cardiovasc. Res. | pmid:25341891 |
Ji M et al. | HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. | 2015 | Oncol. Rep. | pmid:25813246 |
Li Z et al. | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. | 2015 | Gastric Cancer | pmid:24481854 |
Rodrigues MF et al. | Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. | 2015 | J. Cell. Biochem. | pmid:25510910 |
Uchida H et al. | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. | 2015 | J. Pharmacol. Sci. | pmid:26318673 |
Zhang P et al. | Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. | 2015 | PLoS ONE | pmid:26287365 |
Perez-Janices N et al. | Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. | 2015 | Oncotarget | pmid:26284587 |
Keil KP et al. | Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. | 2015 | Dev. Dyn. | pmid:26283270 |
Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
Huan Y et al. | Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. | 2015 | Cell Reprogram | pmid:26053519 |
Kaldre D et al. | Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. | 2015 | Bioorg. Med. Chem. | pmid:26048026 |
Liu Y and Li S | A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. | 2015 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:26022499 |
Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |