trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Atherosclerosis D050197 85 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Reperfusion Injury D015427 65 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Nerve Degeneration D009410 53 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Asthma D001249 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Endometriosis D004715 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Glioblastoma D005909 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Nasal Polyps D009298 26 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Fibrosis D005355 23 associated lipids
Hypersensitivity D006967 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Translocation, Genetic D014178 20 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leishmaniasis D007896 19 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Carcinoma D002277 18 associated lipids
Brain Neoplasms D001932 15 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Radiation Injuries D011832 14 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Neoplasms D009369 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Cat Diseases D002371 12 associated lipids
Keloid D007627 12 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Chondrosarcoma D002813 9 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Enteritis D004751 8 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Genomic Instability D042822 7 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Osteomalacia D010018 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Tomita K et al. The effect of oxidative stress on histone acetylation and IL-8 release. 2003 Biochem. Biophys. Res. Commun. pmid:12565901
Kim Y et al. Decreased syndecan-2 expression correlates with trichostatin-A induced-morphological changes and reduced tumorigenic activity in colon carcinoma cells. 2003 Oncogene pmid:12584561
Mishra N et al. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. 2003 J. Clin. Invest. pmid:12588892
Glaser KB et al. Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. 2003 Mol. Cancer Ther. pmid:12589032
Ailenberg M and Silverman M Differential effects of trichostatin A on gelatinase A expression in 3T3 fibroblasts and HT-1080 fibrosarcoma cells: implications for use of TSA in cancer therapy. 2003 Biochem. Biophys. Res. Commun. pmid:12604329
Sakai N et al. Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells. 2003 J. Biol. Chem. pmid:12609987
Kim SY et al. Glial cell-specific regulation of the JC virus early promoter by histone deacetylase inhibitors. 2003 J. Virol. pmid:12610114
Wang S and Zhu J Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. 2003 J. Biol. Chem. pmid:12611896
Shaker S et al. Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells. 2003 Leuk. Res. pmid:12620295
Dogra SC et al. Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. 2003 Mol. Pharmacol. pmid:12488538
McGhee L et al. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. 2003 J. Cell. Biochem. pmid:12874834
Chun AC and Jin DY Transcriptional regulation of mitotic checkpoint gene MAD1 by p53. 2003 J. Biol. Chem. pmid:12876282
Grisolano JL et al. An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12881486
Konduri SD et al. Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. 2003 Oncogene pmid:12881707
Nakajima M et al. Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. 2003 Toxicol. Lett. pmid:12927368
Liu A et al. Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. 2003 Glia pmid:14603467
Moreira JM et al. The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. 2003 BMC Cancer pmid:14606959
Remiszewski SW et al. N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824). 2003 J. Med. Chem. pmid:14521422
Noh EJ and Lee JS Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2-M transition. 2003 Biochem. Biophys. Res. Commun. pmid:14521905
Li C et al. Effect and comparison of sodium butyrate and trichostatin A on the proliferation/differentiation of K562. 2003 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:14526425
Krämer OH et al. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. 2003 EMBO J. pmid:12840003
Hejnar J et al. Demethylation of host-cell DNA at the site of avian retrovirus integration. 2003 Biochem. Biophys. Res. Commun. pmid:14623319
Margueron R et al. Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells. 2003 J. Endocrinol. pmid:14529564
Adam E et al. Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. 2003 Mol. Cell. Biol. pmid:12917341
Wegener D et al. Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. 2003 Anal. Biochem. pmid:14511685
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Hitomi T et al. p15(INK4b) in HDAC inhibitor-induced growth arrest. 2003 FEBS Lett. pmid:14623092
Zhang Q et al. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. 2003 Toxicol. Appl. Pharmacol. pmid:14575637
Usenko T et al. Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. 2003 Oncogene pmid:14576829
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Chung YL et al. A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. 2003 Mol. Ther. pmid:14599803
Lu F et al. Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. 2003 J. Virol. pmid:14557628
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Marshall S et al. Enhanced expression of uridine diphosphate-N-acetylglucosaminyl transferase (OGT) in a stable, tetracycline-inducible HeLa cell line using histone deacetylase inhibitors: kinetics of cytosolic OGT accumulation and nuclear translocation. 2003 Anal. Biochem. pmid:12871726
Valls E et al. The SV40 T antigen modulates CBP histone acetyltransferase activity. 2003 Nucleic Acids Res. pmid:12799439
Ferguson M et al. Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. 2003 Nucleic Acids Res. pmid:12799440
Ji Y et al. A multistep mechanism for the activation of rearrangement in the immune system. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12802019
Nemajerová A et al. Trichostatin A suppresses transformation by the v-myb oncogene in BM2 cells. 2003 J. Hematother. Stem Cell Res. pmid:12804181
Park PH et al. Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. 2003 Biochem. Biophys. Res. Commun. pmid:12804592
Kim H et al. The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12816733
Klan N et al. Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. 2003 Biol. Chem. pmid:12817474
Yamada Y et al. Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. 2003 Cancer Sci. pmid:12824880
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Kang J et al. Nickel-induced histone hypoacetylation: the role of reactive oxygen species. 2003 Toxicol. Sci. pmid:12773760
Maatouk DM and Resnick JL Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation. 2003 Dev. Biol. pmid:12781693
Ju R and Muller MT Histone deacetylase inhibitors activate p21(WAF1) expression via ATM. 2003 Cancer Res. pmid:12782595
Chua YL et al. The transcriptional enhancer of the pea plastocyanin gene associates with the nuclear matrix and regulates gene expression through histone acetylation. 2003 Plant Cell pmid:12782737
Cecconi D et al. Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A. 2003 Electrophoresis pmid:12783462
Schauber J et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. 2003 Gut pmid:12692061
Rambhatla L et al. Generation of hepatocyte-like cells from human embryonic stem cells. 2003 Cell Transplant pmid:12693659
Lee SC et al. Activation of terminal B cell differentiation by inhibition of histone deacetylation. 2003 Mol. Immunol. pmid:12695118
Chandler SP et al. Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. 2003 BMC Mol. Biol. pmid:12659659
Zika E et al. Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. 2003 Mol. Cell. Biol. pmid:12697811
Mihaylova VT et al. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. 2003 Mol. Cell. Biol. pmid:12697826
Kao GD et al. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. 2003 J. Cell Biol. pmid:12668657
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Jedrusik MA and Schulze E Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. 2003 Mol. Cell. Biol. pmid:12724425
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Detich N et al. The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine. 2003 J. Biol. Chem. pmid:12676953
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Park WH et al. Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. 2003 Int. J. Oncol. pmid:12684681
Farhan H et al. Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. 2003 J. Steroid Biochem. Mol. Biol. pmid:12732287
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Rahman I et al. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. 2002 May-Jun Mol. Cell. Biochem. pmid:12162440
Iwata K et al. Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. 2002 Jul-Aug Cell. Immunol. pmid:12470611
Sourlingas TG et al. The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. 2002 Jan-Mar Exp. Gerontol. pmid:11772521
Zarnegar R et al. Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. 2002 Surgery pmid:12490845
Chen T et al. Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. 2002 Arch. Biochem. Biophys. pmid:12464268
Rombouts K et al. Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. 2002 J. Hepatol. pmid:12445420
Gregory RI et al. Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. 2002 J. Biol. Chem. pmid:11821379
Lim Y et al. Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. 2002 J. Biol. Chem. pmid:11821402
Wilson MA et al. The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo. 2002 J. Biol. Chem. pmid:11821430
Deroanne CF et al. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. 2002 Oncogene pmid:11821955
Handumrongkul C et al. Distinct sets of cellular genes control the expression of transfected, nuclear-localized genes. 2002 Mol. Ther. pmid:11829526
Kishikawa S et al. Roles of histone acetylation in the Dnmt1 gene expression. 2002 Nucleic Acids Res. Suppl. pmid:12903179
Bordonaro M et al. Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. 2002 Int. J. Cancer pmid:11774242
Kikuchi T et al. Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. 2002 Int. J. Cancer pmid:11774276
Rombouts K et al. Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. 2002 Exp. Cell Res. pmid:12169274
Waterborg JH and Kapros T Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. 2002 Biochem. Cell Biol. pmid:12123281
Curradi M et al. Molecular mechanisms of gene silencing mediated by DNA methylation. 2002 Mol. Cell. Biol. pmid:11940673
Koyama N et al. Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. 2002 Biochem. Biophys. Res. Commun. pmid:11944905
Nair RR et al. Enhancement of transgene expression by combining glucocorticoids and anti-mitotic agents during transient transfection using DNA-cationic liposomes. 2002 Mol. Ther. pmid:11945073
Qiu P and Li L Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression. 2002 Circ. Res. pmid:11988486
Mai A et al. Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. 2002 J. Med. Chem. pmid:11960489
Merezak C et al. Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo. 2002 J. Virol. pmid:11967319
Im H et al. Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. 2002 Biochemistry pmid:12484752
Gong XQ and Li L Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. 2002 J. Biol. Chem. pmid:11809751
Rössig L et al. Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. 2002 Circ. Res. pmid:12411399
Chen Z et al. Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. 2002 Cancer Lett. pmid:12406558
Gálfi P et al. Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. 2002 Cancer Lett. pmid:12406559
Travers H et al. Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. 2002 Exp. Cell Res. pmid:12413881
Wilson AJ et al. Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. 2002 Cancer Res. pmid:12414619
Choy JS and Kron SJ NuA4 subunit Yng2 function in intra-S-phase DNA damage response. 2002 Mol. Cell. Biol. pmid:12417725
Ghoshal K et al. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. 2002 Mol. Cell. Biol. pmid:12417732
Hauser C et al. Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. 2002 Mol. Cell. Biol. pmid:12391151