Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang LG et al. | Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. | 2004 | Oncogene | pmid:15156193 |
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Tessema M et al. | Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. | 2010 | Oncogene | pmid:20562917 |
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Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
Futamura M et al. | Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells. | 1995 | Oncogene | pmid:7700637 |
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Karagiannis TC et al. | Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. | 2007 | Oncogene | pmid:17213813 |
Sengupta S et al. | Tumor suppressor p53 represses transcription of RECQ4 helicase. | 2005 | Oncogene | pmid:15674334 |
Busson M et al. | Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. | 2005 | Oncogene | pmid:15674337 |
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Chan AS et al. | Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. | 2003 | Oncogene | pmid:14534543 |
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Shteper PJ et al. | Role of promoter methylation in regulation of the mammalian heparanase gene. | 2003 | Oncogene | pmid:14586400 |
Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
Meng Z et al. | PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. | 2016 | Oncogene | pmid:26279303 |
Ibanez de Caceres I et al. | IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. | 2010 | Oncogene | pmid:20023704 |
Zubia A et al. | Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. | 2009 | Oncogene | pmid:19169274 |
Kumar KS et al. | Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. | 2006 | Oncol. Rep. | pmid:17016591 |
Kang FW et al. | Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. | 2012 | Oncol. Rep. | pmid:22552321 |
Meng J et al. | The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. | 2012 | Oncol. Rep. | pmid:22552631 |
Rhodes LV et al. | The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. | 2012 | Oncol. Rep. | pmid:21971930 |
Kim SH et al. | Regulation of the HIF-1alpha stability by histone deacetylases. | 2007 | Oncol. Rep. | pmid:17273746 |
Anh TD et al. | The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells. | 2012 | Oncol. Rep. | pmid:21993600 |
Ganslmayer M et al. | A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. | 2004 | Oncol. Rep. | pmid:15069530 |
Ma X et al. | Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. | 2015 | Oncol. Rep. | pmid:25420545 |
Wang B et al. | Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. | 2014 | Oncol. Rep. | pmid:25224651 |
Wang JH et al. | HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. | 2018 | Oncol. Rep. | pmid:29767267 |
Zhang X et al. | Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. | 2018 | Oncol. Rep. | pmid:29393444 |
Ji M et al. | HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. | 2015 | Oncol. Rep. | pmid:25813246 |
Um SJ et al. | In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group. | 2004 | Oncol. Rep. | pmid:14767528 |
Wu DS et al. | Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. | 2013 | Oncol. Rep. | pmid:24064951 |
Shao G et al. | Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation. | 2017 | Oncol. Rep. | pmid:28393191 |
Nakajima S et al. | Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. | 2009 | Oncol. Rep. | pmid:19513516 |
Zuo X et al. | Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. | 2014 | Oncol. Rep. | pmid:24676336 |
Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
Jia L et al. | Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. | 2017 | Oncol. Rep. | pmid:27878285 |
Zhang NH et al. | Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. | 2016 | Oncol. Rep. | pmid:27373420 |
Kang HR et al. | Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. | 2016 | Oncol. Rep. | pmid:27277338 |
Qiao F et al. | Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells. | 2012 | Oncol. Rep. | pmid:22825043 |
Liu Z et al. | Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. | 2008 | Oncol. Rep. | pmid:18575731 |
Wang SC et al. | Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. | 2017 | Oncol. Rep. | pmid:28713892 |
Puppin C et al. | Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. | 2011 | Oncol. Rep. | pmid:21152868 |
Androutsopoulos VP and Spandidos DA | Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. | 2017 | Oncol. Rep. | pmid:29039546 |
Zhang X et al. | Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. | 2006 | Oncol. Rep. | pmid:16865256 |
Villanueva R et al. | Histone deacetylase 3 represses HTLV-1 tax transcription. | 2006 | Oncol. Rep. | pmid:16865259 |
Puppin C et al. | Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. | 2011 | Oncol. Rep. | pmid:21617864 |
Seo JS et al. | Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin A. | 2008 | Oncol. Rep. | pmid:18097580 |
Meng CF et al. | Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells. | 2009 | Oncol. Rep. | pmid:19787243 |
Tamannai M et al. | The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. | 2010 | Oncol. Res. | pmid:20681406 |
Lin S et al. | Silencing of ATP4B of ATPase H/K Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. | 2017 | Oncol. Res. | pmid:28281974 |
Chiba T et al. | Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. | 2004 | Oncology | pmid:15452378 |
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Chen L et al. | PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. | 2017 | Oncotarget | pmid:28060760 |
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Vanommeslaeghe K et al. | Ab initio study of the binding of Trichostatin A (TSA) in the active site of histone deacetylase like protein (HDLP). | 2003 | Org. Biomol. Chem. | pmid:12968347 |
Chatterjee A et al. | An efficient synthesis of (+/-)-trichostatic Acid and analogues: a new route to (+/-)-trichostatin A. | 2010 | Org. Lett. | pmid:20104892 |
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Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
Chen HY et al. | Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. | 2014 | Pharmazie | pmid:24601225 |
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