trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Nerve Degeneration D009410 53 associated lipids
Asthma D001249 52 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Osteosarcoma D012516 50 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Stroke D020521 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Endometriosis D004715 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Glioblastoma D005909 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Fibrosis D005355 23 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Medulloblastoma D008527 22 associated lipids
Hypersensitivity D006967 22 associated lipids
Translocation, Genetic D014178 20 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leishmaniasis D007896 19 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Carcinoma D002277 18 associated lipids
Brain Neoplasms D001932 15 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Radiation Injuries D011832 14 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Neoplasms D009369 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Cat Diseases D002371 12 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Keloid D007627 12 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Enteritis D004751 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Genomic Instability D042822 7 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Osteomalacia D010018 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Retinal Neoplasms D019572 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Lietz M et al. RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. 2003 Eur. J. Biochem. pmid:12492469
Yamashita Y et al. Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells. 2003 Int. J. Cancer pmid:12494463
Parekh-Olmedo H et al. The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. 2003 Ann. N. Y. Acad. Sci. pmid:14751821
Senawong T et al. Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. 2003 J. Biol. Chem. pmid:12930829
Mulholland NM et al. Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation. 2003 Oncogene pmid:12894222
Banwell CM et al. Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation. 2003 Recent Results Cancer Res. pmid:12899515
Yan Y et al. Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. 2003 Toxicol. Appl. Pharmacol. pmid:12902198
Augenlicht L et al. Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation. 2003 Oncogene pmid:12902981
Thomas RM et al. Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of mammary tumor virus superantigen. 2003 J. Immunol. pmid:12496403
Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. 2003 Chem. Biol. pmid:12770822
Agoulnik IU et al. Repressors of androgen and progesterone receptor action. 2003 J. Biol. Chem. pmid:12771131
Huang Y et al. Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. 2003 Int. J. Cancer pmid:12640681
Coombes MM et al. Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. 2003 Oncogene pmid:14654786
Chan AS et al. Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. 2003 Oncogene pmid:14534543
Allison SJ and Milner J Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. 2003 Cancer Res. pmid:14583461
Vanommeslaeghe K et al. Ab initio study of the binding of Trichostatin A (TSA) in the active site of histone deacetylase like protein (HDLP). 2003 Org. Biomol. Chem. pmid:12968347
Huang H et al. [HDAC1 expression and effect of TSA on proliferation and apoptosis of A549 cells]. 2003 Ai Zheng pmid:12969522
Ohike N et al. Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. 2003 Cancer Lett. pmid:12969792
Fass DM et al. Deacetylase activity is required for cAMP activation of a subset of CREB target genes. 2003 J. Biol. Chem. pmid:12939274
Zhao C et al. A composite motif of the Drosophila morphogenetic protein bicoid critical to transcription control. 2003 J. Biol. Chem. pmid:12939280
Hoever G et al. The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. 2003 Int. J. Mol. Med. pmid:12736716
Valenta T et al. HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells. 2003 Nucleic Acids Res. pmid:12711682
Arora T et al. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. 2003 J. Biol. Chem. pmid:12716907
Sonoyama K et al. Upregulation of activin A gene by butyrate in human colon cancer cell lines. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12540370
Kao HH et al. Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. 2003 Jan-Feb J. Biomed. Sci. pmid:12566991
Kagoshima M et al. How signaling pathways interact with gene transcription. 2003 Jan-Mar Monaldi Arch Chest Dis pmid:14533280
Swank RA et al. The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. 2003 May-Jun Blood Cells Mol. Dis. pmid:12737942
Amor DJ et al. Human centromere repositioning "in progress". 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15084747
Tani M et al. Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells. 2004 Genes Chromosomes Cancer pmid:15101048
Lasa A et al. MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. 2004 Leukemia pmid:15103390
Yokota T et al. Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. 2004 Oncogene pmid:15107822
McGarry LC et al. Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. 2004 Oncogene pmid:15107823
Chen YX et al. [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. 2004 Zhonghua Yi Xue Za Zhi pmid:15059516
Hildmann C et al. A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. 2004 J. Bacteriol. pmid:15060035
Vorontsova M et al. Effect of 5-azacytidine and trichostatin A on somatic centromere association in wheat. 2004 Genome pmid:15060593
Tong X et al. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. 2004 Biochem. Biophys. Res. Commun. pmid:15063780
Kurtev V et al. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. 2004 J. Biol. Chem. pmid:15140878
Vaisburg A et al. (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. 2004 Bioorg. Med. Chem. Lett. pmid:14684344
Leu TH et al. Participation of p97Eps8 in Src-mediated transformation. 2004 J. Biol. Chem. pmid:14699156
Pagans S et al. Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. 2004 J. Biol. Chem. pmid:14701830
Hwang CK et al. Transcriptional regulation of mouse mu opioid receptor gene by PU.1. 2004 J. Biol. Chem. pmid:14998994
Brush MH et al. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 2004 J. Biol. Chem. pmid:14670976
Gray SG et al. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. 2004 Int. J. Oncol. pmid:15010814
Lee JH et al. Histone deacetylase activity is required for embryonic stem cell differentiation. 2004 Genesis pmid:14755802
Lemonde S et al. Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. 2004 J. Neurochem. pmid:14756806
Aapola U et al. Epigenetic modifications affect Dnmt3L expression. 2004 Biochem. J. pmid:15015937
Hattori N et al. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. 2004 J. Biol. Chem. pmid:14761969
Burton GR et al. Microarray analysis of differentiation-specific gene expression during 3T3-L1 adipogenesis. 2004 Gene pmid:15033539
David GL et al. MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. 2004 Cancer Biol. Ther. pmid:15034303
Liu X et al. Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. 2004 Biochem. Pharmacol. pmid:15041467
Elaut G et al. Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors. 2004 Altern Lab Anim pmid:23577441
Christian M et al. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. 2004 J. Biol. Chem. pmid:14736873
Mai A et al. 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. 2004 J. Med. Chem. pmid:14971890
Milhem M et al. Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. 2004 Blood pmid:14976039
Agostinho M et al. Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. 2004 Mol. Biol. Cell pmid:14978217
Sakata R et al. Trichostatin A activates the osteopontin gene promoter through AP1 site. 2004 Biochem. Biophys. Res. Commun. pmid:14985105
Knobbe CB et al. Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. 2004 J. Natl. Cancer Inst. pmid:15026474
Chung YL et al. Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy. 2004 Mol. Cancer Ther. pmid:15026552
Cao H et al. Induction of human gamma globin gene expression by histone deacetylase inhibitors. 2004 Blood pmid:12920038
Sarg B et al. Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. 2004 J. Biol. Chem. pmid:15456746
Nan X et al. Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. 2004 Biochem. Biophys. Res. Commun. pmid:15465025
Lee HS et al. Gene expression analysis in human gastric cancer cell line treated with trichostatin A and S-adenosyl-L-homocysteine using cDNA microarray. 2004 Biol. Pharm. Bull. pmid:15467184
Sangster-Guity N et al. Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment. 2004 Cancer Biol. Ther. pmid:15467438
Emmans VC et al. Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. 2004 Biochem. Soc. Trans. pmid:15494029
Keen JC et al. Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells. 2004 Cancer Biol. Ther. pmid:15662126
Ding W [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]. 2004 Hokkaido Igaku Zasshi pmid:15675303
Yamashita Y et al. cDNA microarray analysis in hepatocyte differentiation in Huh 7 cells. 2004 Cell Transplant pmid:15690981
García I et al. Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. 2004 Eukaryotic Cell pmid:14871945
Takai N et al. Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. 2004 Clin. Cancer Res. pmid:14871994
Zhang Y et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. 2004 Radiat. Res. pmid:15161353
Glenn MP et al. Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. 2004 J. Med. Chem. pmid:15163181
Ronai D et al. The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature. 2004 Genetics pmid:15166165
Zhang X et al. Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. 2004 Mol. Cell. Biol. pmid:15169878
Ishiguro K and Sartorelli AC Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. 2004 Eur. J. Biochem. pmid:15182353
Brieger A et al. In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. 2004 Biochem. Pharmacol. pmid:15183120
Shim JS et al. Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. 2004 Oncogene pmid:14661058
Laeng P et al. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. 2004 J. Neurochem. pmid:15379904
Kim MK and Carroll WL Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. 2004 Cancer pmid:15382088
Tang XX et al. Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. 2004 Clin. Cancer Res. pmid:15355914
Yokota T et al. Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. 2004 FEBS Lett. pmid:15358560
Boehrer S et al. In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. 2004 Leuk. Lymphoma pmid:15359646
Vaghefi H and Neet KE Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. 2004 Oncogene pmid:15361854
Moore PS et al. Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. 2004 Biochim. Biophys. Acta pmid:15363630
Chiba T et al. Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. 2004 J. Hepatol. pmid:15336447
Jansen MS et al. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15103026
Sanderson L et al. Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. 2004 Drug Metab. Dispos. pmid:15269190
Levenson JM et al. Regulation of histone acetylation during memory formation in the hippocampus. 2004 J. Biol. Chem. pmid:15273246
Liu C and Xu D Inhibition of histone deacetylases. 2004 Methods Mol. Biol. pmid:15273406
Garfinkel MD et al. Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila. 2004 Methods Mol. Biol. pmid:15273410
Vanhaecke T et al. Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. 2004 Biochem. Pharmacol. pmid:15276083
ChuÄ­kin IA et al. [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. 2004 Tsitologiia pmid:15747838
Korzus E et al. CBP histone acetyltransferase activity is a critical component of memory consolidation. 2004 Neuron pmid:15207240
Ishihara K et al. Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils. 2004 Br. J. Pharmacol. pmid:15210580
Marengo E et al. Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. 2004 Anal Bioanal Chem pmid:15257427
Schauber J et al. Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. 2004 Mol. Immunol. pmid:15261456
De La Fuente R et al. ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. 2004 Dev. Biol. pmid:15242786
Fang JY et al. Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116. 2004 Cell Res. pmid:15225415
Banwell CM et al. Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. 2004 J. Steroid Biochem. Mol. Biol. pmid:15225779
Mao DY et al. Promoter-binding and repression of PDGFRB by c-Myc are separable activities. 2004 Nucleic Acids Res. pmid:15226411
Alao JP et al. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. 2004 Clin. Cancer Res. pmid:15585645