trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Asthma D001249 52 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Body Weight D001835 333 associated lipids
Brain Neoplasms D001932 15 associated lipids
Breast Neoplasms D001943 24 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Cat Diseases D002371 12 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Chondrosarcoma D002813 9 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endometriosis D004715 29 associated lipids
Enteritis D004751 8 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Fibrosis D005355 23 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Ganglioneuroma D005729 2 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Goldenhar Syndrome D006053 1 associated lipids
Cardiomegaly D006332 31 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypesthesia D006987 1 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Inflammation D007249 119 associated lipids
Chromosome Inversion D007446 1 associated lipids
Keloid D007627 12 associated lipids
Leishmaniasis D007896 19 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Intellectual Disability D008607 13 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Nasal Polyps D009298 26 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neoplasms D009369 13 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuroblastoma D009447 66 associated lipids
Osteomalacia D010018 5 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Progeria D011371 3 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Radiation Injuries D011832 14 associated lipids
Retinoblastoma D012175 12 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Osteosarcoma D012516 50 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Translocation, Genetic D014178 20 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Supratentorial Neoplasms D015173 1 associated lipids
Reperfusion Injury D015427 65 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
He D et al. Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. 2012 Eur. J. Cancer Prev. pmid:22273848
Hosoya T et al. Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. 2012 J. Nat. Prod. pmid:22276693
de Souza CF et al. Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. 2012 PLoS ONE pmid:22984562
Cheng DD et al. Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. 2012 Asian Pac. J. Cancer Prev. pmid:22799338
Nunes MJ et al. Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway. 2012 J. Lipid Res. pmid:22693257
Karolczak-Bayatti M et al. Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. 2012 Reprod Sci pmid:22875848
Sustáčková G et al. Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. 2012 J. Cell. Physiol. pmid:21732356
Mostovich LA et al. Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. 2011 Sep-Oct Cell Adh Migr pmid:21975548
Stepanek I et al. Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. 2011 Oct-Dec J. Biol. Regul. Homeost. Agents pmid:22217985
Kee HJ et al. Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. 2011 Nov-Dec Vascul. Pharmacol. pmid:21763782
Meng CF et al. DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. 2011 Nov-Dec Mol Med Rep pmid:21850374
Cowell IG et al. Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. 2011 Jan-Feb Nucleus pmid:21647300
Aoyama K et al. Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. 2011 Exp. Cell Res. pmid:22001646
Jeon HG et al. Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. 2011 J. Urol. pmid:21944112
Meester-Smoor MA et al. The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. 2011 PLoS ONE pmid:21949683
Halder SK et al. Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. 2011 Neoplasia pmid:22028617
Bo F et al. Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. 2011 Zygote pmid:20569515
Hutt DM et al. Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. 2011 ACS Med Chem Lett pmid:21984958
Hirata H et al. Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. 2011 Int. J. Cancer pmid:20549706
Kaichi S et al. Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. 2011 J. Cell. Physiol. pmid:20665673
Pichugin A et al. Ring-like distribution of constitutive heterochromatin in bovine senescent cells. 2011 PLoS ONE pmid:22132080
Marrazzo A et al. Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. 2011 Eur J Med Chem pmid:21055848
Gao A et al. Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. 2011 Cell Biol. Int. pmid:21143203
Wang YS et al. Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. 2011 Theriogenology pmid:21144561
Shiratsuki S et al. Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. 2011 Theriogenology pmid:21144563
Poljakova J et al. Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. 2011 Neuro Endocrinol. Lett. pmid:22167207
Williams PJ et al. HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. 2011 Ann. N. Y. Acad. Sci. pmid:22172035
Xia B et al. Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. 2011 Toxicol. Lett. pmid:21641978
Seo SK et al. Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. 2011 J Thorac Oncol pmid:21642861
Acun T et al. SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. 2011 BMC Cancer pmid:21645397
Hou J et al. Structure-based optimization of click-based histone deacetylase inhibitors. 2011 Eur J Med Chem pmid:21621883
Gaub P et al. The histone acetyltransferase p300 promotes intrinsic axonal regeneration. 2011 Brain pmid:21705428
Song K et al. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. 2011 Cancer Biol. Ther. pmid:21709440
Hauff KD et al. Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. 2011 Lipids pmid:21710238
Yoo YE and Ko CP Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. 2011 Exp. Neurol. pmid:21712032
Zhang Y et al. ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. 2011 Toxicon pmid:21419152
WEI Q et al. [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. 2011 Nan Fang Yi Ke Da Xue Xue Bao pmid:21421475
Jergil M et al. Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. 2011 Toxicol. Sci. pmid:21427059
Diao JS et al. Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. 2011 Arch. Dermatol. Res. pmid:21400246
Zhang J et al. Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. 2011 Endocrinology pmid:21406501
Kawasaki H et al. Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. 2011 PLoS ONE pmid:21407806
Li Z et al. Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. 2011 Cell Biol. Int. pmid:21314642
Saiyed ZM et al. HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). 2011 Neurochem. Int. pmid:21315782
Fang Y et al. Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. 2011 Cancer Invest. pmid:21345073
Qian Y et al. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. 2011 J. Biol. Chem. pmid:21317427
Zhang F et al. Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. 2011 PLoS ONE pmid:21346816
Hizaki K et al. Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. 2011 Mod. Pathol. pmid:21317879
Zhou X et al. Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. 2011 J. Clin. Immunol. pmid:21305388
Meli M et al. Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. 2011 Int. J. Oncol. pmid:21318222
Turovets N et al. Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. 2011 Differentiation pmid:21306817
Yang H et al. Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. 2011 Hepatology pmid:21319187
Patel T et al. Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. 2011 Immunol. Cell Biol. pmid:21321581
Chaurasia P et al. Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. 2011 Blood pmid:21355088
Shi G et al. The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. 2011 J. Cell. Physiol. pmid:21321941
Furuta K et al. The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. 2011 Plant Cell Physiol. pmid:21357580
Kim YJ et al. Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos. 2011 In Vitro Cell. Dev. Biol. Anim. pmid:21359816
Biermann J et al. Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells. 2011 Mol. Vis. pmid:21311741
Fortson WS et al. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. 2011 Int. J. Oncol. pmid:21519790
Inoue H et al. Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation. 2011 Mol. Cell. Endocrinol. pmid:21756973
Wang Y et al. The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. 2011 Cell Reprogram pmid:21486115
Watanabe Y and Tanaka M p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. 2011 J. Cell. Sci. pmid:21771882
Hattori N et al. Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 2011 Cancer Sci. pmid:21489049
Miller L et al. Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. 2011 Physiol. Behav. pmid:21463644
Tost J et al. Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. 2011 Epigenetics pmid:21775817
Law AY et al. Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. 2011 J. Cell. Biochem. pmid:21465530
Blanquart C et al. Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. 2011 Curr Cancer Drug Targets pmid:21762083
Pang M et al. Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. 2011 J. Cell. Biochem. pmid:21465537
Wan Y et al. Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. 2011 FEBS Lett. pmid:21763693
Kimura T et al. Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. 2011 J Toxicol Sci pmid:21467744
Zhang CZ et al. Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. 2011 Apoptosis pmid:21468663
Hu Y et al. Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. 2011 PLoS ONE pmid:21811564
Chen YT et al. Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. 2011 Spine pmid:21343850
Lee MJ et al. Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. 2011 J. Reprod. Dev. pmid:20834196
Amoêdo ND et al. Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. 2011 PLoS ONE pmid:21789245
Sengupta S et al. Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. 2011 Oncogene pmid:20856196
Arzenani MK et al. Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. 2011 Mol. Cell. Biol. pmid:21791605
Costa VL et al. TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. 2011 Epigenetics pmid:21847011
Cai HH et al. Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. 2011 HBPD INT pmid:21269942
Lee SC et al. HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. 2011 J. Biomed. Biotechnol. pmid:21253530
Chen WP et al. Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. 2011 Rheumatol. Int. pmid:20390279
Yoon CY et al. The histone deacetylase inhibitor trichostatin A synergistically resensitizes a cisplatin resistant human bladder cancer cell line. 2011 J. Urol. pmid:21255805
Choi E et al. Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. 2011 Bioorg. Med. Chem. Lett. pmid:21256006
Mizuno S et al. Inhibition of histone deacetylase causes emphysema. 2011 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21224215
Hai T et al. Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. 2011 Cell Reprogram pmid:21241188
Zou CF et al. Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. 2011 BMC Cancer pmid:21244707
Nakamura J et al. Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. 2011 Am. J. Pathol. pmid:21281785
Puppin C et al. In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. 2011 Cell Oncol (Dordr) pmid:21290209
Ishiguro K et al. Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction. 2011 J. Immunol. pmid:21278340
Ma AN et al. Histone deacetylation directs DNA methylation in survivin gene silencing. 2011 Biochem. Biophys. Res. Commun. pmid:21130077
Pianta A et al. Nucleophosmin delocalization in thyroid tumour cells. 2011 Endocr. Pathol. pmid:21258971
Gómez MC et al. Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. 2011 Cell Reprogram pmid:21718106
Whitehead L et al. Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. 2011 Bioorg. Med. Chem. pmid:21723733
Puppin C et al. Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. 2011 Oncol. Rep. pmid:21617864
Shu G et al. Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. 2011 Cell Death Differ. pmid:21546906
Vojdani Z et al. Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. 2011 Hum. Cell pmid:21547694
Neelarapu R et al. Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. 2011 J. Med. Chem. pmid:21548582
Vassiliev I et al. Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. 2011 Cell Reprogram pmid:21548828
Ververis K et al. Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. 2011 Cell. Mol. Life Sci. pmid:21584806
Misaki K et al. Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. 2011 Arthritis Res. Ther. pmid:21592365
Selinger CI et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. 2011 J Thorac Oncol pmid:21597389