Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yang X et al. | Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. | 2001 | Cancer Res. | pmid:11585728 |
Luo W et al. | Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer. | 2010 | Cancer Res. | pmid:20587525 |
James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
Terui T et al. | Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. | 2003 | Cancer Res. | pmid:14695212 |
Shah S et al. | Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. | 2012 | Cancer Res. | pmid:22258452 |
Sharma D et al. | Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. | 2006 | Cancer Res. | pmid:16778215 |
Shi J et al. | Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. | 2007 | Cancer Res. | pmid:17616702 |
Sugita K et al. | Morphological reversion of sis-transformed NIH3T3 cells by trichostatin A. | 1992 | Cancer Res. | pmid:1727377 |
Yoshida M et al. | Effects of trichostatins on differentiation of murine erythroleukemia cells. | 1987 | Cancer Res. | pmid:2439196 |
Sirchia SM et al. | Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. | 2002 | Cancer Res. | pmid:11980632 |
Heller G et al. | Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. | 2008 | Cancer Res. | pmid:18172295 |
Kretzner L et al. | Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. | 2011 | Cancer Res. | pmid:21502403 |
Medina V et al. | Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. | 1997 | Cancer Res. | pmid:9288776 |
Harada K et al. | Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. | 2002 | Cancer Res. | pmid:12384554 |
Ho WC et al. | Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. | 2005 | Cancer Res. | pmid:15899819 |
Tran T et al. | Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. | 2005 | Cancer Res. | pmid:15899836 |
Liu LT et al. | Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. | 2003 | Cancer Res. | pmid:12810630 |
Allison SJ and Milner J | Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. | 2003 | Cancer Res. | pmid:14583461 |
Sowa Y et al. | Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. | 1999 | Cancer Res. | pmid:10485470 |
Lin YC et al. | Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. | 2008 | Cancer Res. | pmid:18381445 |
Wang J et al. | Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. | 1999 | Cancer Res. | pmid:10383127 |
Zhao S et al. | Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells. | 2003 | Cancer Res. | pmid:12750289 |
Stiehl DP et al. | Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation. | 2007 | Cancer Res. | pmid:17332356 |
Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
Nervi C et al. | Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. | 2001 | Cancer Res. | pmid:11245412 |
Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |
Mousa SA et al. | Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. | 2010 | Cancer Lett. | pmid:19733430 |
Sugimoto S et al. | Expression and regulation of tumor suppressor gene maspin in human bladder cancer. | 2004 | Cancer Lett. | pmid:14732229 |
Li Y et al. | Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. | 2012 | Cancer Lett. | pmid:22266186 |
Jung EJ et al. | Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir. | 2007 | Cancer Lett. | pmid:16647201 |
Davies GF et al. | Troglitazone inhibits histone deacetylase activity in breast cancer cells. | 2010 | Cancer Lett. | pmid:19699029 |
Hostetter CL et al. | Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. | 2009 | Cancer Lett. | pmid:19013015 |
Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
Pitta CA et al. | Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. | 2013 | Cancer Lett. | pmid:23752064 |
Nair AR et al. | Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. | 2001 | Cancer Lett. | pmid:11295287 |
Zhang Q et al. | Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. | 2014 | Cancer Lett. | pmid:25109451 |
Liu RF et al. | Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. | 2013 | Cancer Lett. | pmid:23142219 |
Chen H et al. | LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. | 2012 | Cancer Lett. | pmid:22743615 |
Januchowski R et al. | Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. | 2007 | Cancer Lett. | pmid:16624484 |
Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
Bharadwaj S and Prasad GL | Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells. | 2002 | Cancer Lett. | pmid:12065096 |
Bazhin AV et al. | Expression of GAGE family proteins in malignant melanoma. | 2007 | Cancer Lett. | pmid:17194529 |
Al-Rayyan N et al. | 5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines. | 2014 | Cancer Lett. | pmid:24513177 |
Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
Ryu JK et al. | SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. | 2006 | Cancer Lett. | pmid:16009488 |
Jung JW et al. | Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. | 2006 | Cancer Lett. | pmid:16337085 |
Ohike N et al. | Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas. | 2003 | Cancer Lett. | pmid:12969792 |
Hoebeeck J et al. | Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. | 2009 | Cancer Lett. | pmid:18819746 |
Liu Y et al. | Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines. | 2008 | Cancer Invest. | pmid:18584348 |