trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yokota T et al. | Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. | 2004 | Oncogene | pmid:15107822 |
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| Chen YX et al. | [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. | 2004 | Zhonghua Yi Xue Za Zhi | pmid:15059516 |
| Hildmann C et al. | A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. | 2004 | J. Bacteriol. | pmid:15060035 |
| Vorontsova M et al. | Effect of 5-azacytidine and trichostatin A on somatic centromere association in wheat. | 2004 | Genome | pmid:15060593 |
| Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
| Kurtev V et al. | Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. | 2004 | J. Biol. Chem. | pmid:15140878 |
| Kim YH et al. | Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. | 2004 | Carcinogenesis | pmid:15142888 |
| Klampfer L et al. | Requirement of histone deacetylase activity for signaling by STAT1. | 2004 | J. Biol. Chem. | pmid:15123634 |
| Fu M et al. | The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. | 2004 | J. Biol. Chem. | pmid:15123687 |
| Phan D et al. | Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. | 2004 | Cancer Res. | pmid:15126343 |
| Iezzi S et al. | Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. | 2004 | Dev. Cell | pmid:15130492 |
| Bort R et al. | Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. | 2004 | Arch. Biochem. Biophys. | pmid:15130783 |
| Ishii S et al. | Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone. | 2004 | Mol. Endocrinol. | pmid:15131262 |
| Winn RA and Heasley LE | Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. | 2004 | Chest | pmid:15136458 |
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| Lemonde S et al. | Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. | 2004 | J. Neurochem. | pmid:14756806 |
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| Knobbe CB et al. | Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. | 2004 | J. Natl. Cancer Inst. | pmid:15026474 |
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| Zelko IN and Folz RJ | Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. | 2004 | Free Radic. Biol. Med. | pmid:15451065 |
| Steiner E et al. | SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047174 |
| Chiba T et al. | Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. | 2004 | Oncology | pmid:15452378 |
| Kypreou KP et al. | Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A. | 2004 | Exp. Gerontol. | pmid:15050280 |
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| Lee HS et al. | Gene expression analysis in human gastric cancer cell line treated with trichostatin A and S-adenosyl-L-homocysteine using cDNA microarray. | 2004 | Biol. Pharm. Bull. | pmid:15467184 |
| Sangster-Guity N et al. | Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment. | 2004 | Cancer Biol. Ther. | pmid:15467438 |
| Alcendor RR et al. | Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. | 2004 | Circ. Res. | pmid:15486319 |
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| De La Fuente R et al. | Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. | 2004 | Dev. Biol. | pmid:15501230 |
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| El-Khoury V et al. | Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. | 2004 | Cytometry A | pmid:15517561 |
| Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
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| Zhang X et al. | Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. | 2004 | Mol. Cell. Biol. | pmid:15169878 |
| Ishiguro K and Sartorelli AC | Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | 2004 | Eur. J. Biochem. | pmid:15182353 |
| Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
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| Yokota T et al. | Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. | 2004 | FEBS Lett. | pmid:15358560 |
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| Banwell CM et al. | Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15225779 |
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| Sakamoto S et al. | Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. | 2004 | J. Biol. Chem. | pmid:15194680 |
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| Emionite L et al. | Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | 2004 Nov-Dec | Anticancer Res. | pmid:15736447 |
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