trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Adenomyosis D062788 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Visceral Pain D059265 1 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Capsule Opacification D058442 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Atherosclerosis D050197 85 associated lipids
Genomic Instability D042822 7 associated lipids
Mastocytoma D034801 3 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Stroke D020521 32 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Roseolovirus Infections D019349 1 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Rhabdoid Tumor D018335 1 associated lipids
Cystadenoma, Serous D018293 1 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Rhabdomyosarcoma, Embryonal D018233 1 associated lipids
Rhabdomyosarcoma, Alveolar D018232 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Reperfusion Injury D015427 65 associated lipids
Supratentorial Neoplasms D015173 1 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Translocation, Genetic D014178 20 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Osteosarcoma D012516 50 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Retinoblastoma D012175 12 associated lipids
Radiation Injuries D011832 14 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Progeria D011371 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Osteomalacia D010018 5 associated lipids
Neuroblastoma D009447 66 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasms D009369 13 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Nasal Polyps D009298 26 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Intellectual Disability D008607 13 associated lipids
Melanoma D008545 69 associated lipids
Medulloblastoma D008527 22 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia D007938 74 associated lipids
Leishmaniasis D007896 19 associated lipids
Keloid D007627 12 associated lipids
Chromosome Inversion D007446 1 associated lipids
Inflammation D007249 119 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Hypesthesia D006987 1 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity D006967 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Endo M et al. Novel gender-related regulation of CYP2C12 gene expression in rats. 2005 Mol. Endocrinol. pmid:15661834
Schmittwolf C et al. In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. 2005 EMBO J. pmid:15660132
Marsili G et al. Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. 2004 Ann. N. Y. Acad. Sci. pmid:15659847
Li Y et al. Histone deacetylation is required for progression through mitosis in tobacco cells. 2005 Plant J. pmid:15659094
Danam RP et al. Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. 2005 Mol. Cancer Ther. pmid:15657354
Huang H et al. MEIS C termini harbor transcriptional activation domains that respond to cell signaling. 2005 J. Biol. Chem. pmid:15654074
Kemp MG et al. The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. 2005 Nucleic Acids Res. pmid:15653633
Shindo N et al. The ESC-E(Z) complex participates in the hedgehog signaling pathway. 2005 Biochem. Biophys. Res. Commun. pmid:15652519
Kang J et al. Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. 2005 Toxicol In Vitro pmid:15649630
Choi JH et al. Trichostatin A attenuates airway inflammation in mouse asthma model. 2005 Clin. Exp. Allergy pmid:15649272
Huang W et al. Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. 2005 J. Biol. Chem. pmid:15647279
Farrajota K et al. Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. 2005 Arthritis Rheum. pmid:15641079
Senawong T et al. BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. 2005 Arch. Biochem. Biophys. pmid:15639232
Kondo T et al. Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. 2005 Oncogene pmid:15637589
Maxhimer JB et al. Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). 2005 J. Thorac. Cardiovasc. Surg. pmid:15632825
Ezzat S et al. The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. 2005 Mol. Endocrinol. pmid:15618287
Bottardi S et al. Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells. 2005 Hum. Mol. Genet. pmid:15615768
Fujisawa K et al. Epigenetic status and aberrant expression of the maspin gene in human hepato-biliary tract carcinomas. 2005 Lab. Invest. pmid:15608662
Zhao Y et al. Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. 2005 Biochem. Biophys. Res. Commun. pmid:15607742
Bayart E et al. A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. 2004 Cancer Res. pmid:15604258
Goeman F et al. Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. 2005 Mol. Cell. Biol. pmid:15601862
Davidson SM et al. The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. 2005 Chembiochem pmid:15593114
Karasawa Y and Okisaka S Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells. 2004 Nov-Dec Jpn. J. Ophthalmol. pmid:15592778
Sato N et al. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. 2005 Oncogene pmid:15592528
Alao JP et al. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. 2004 Clin. Cancer Res. pmid:15585645
Varshochi R et al. ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. 2005 J. Biol. Chem. pmid:15557281
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Hammond SM et al. Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. 2005 Leuk. Res. pmid:15541480
Kawano T et al. Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect. 2004 Sep-Oct Anticancer Res. pmid:15517875
El-Khoury V et al. Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. 2004 Cytometry A pmid:15517561
Wang S and Zhu J The hTERT gene is embedded in a nuclease-resistant chromatin domain. 2004 J. Biol. Chem. pmid:15516693
Chang S and Pikaard CS Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation. 2005 J. Biol. Chem. pmid:15516340
Lin AC et al. The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. 2004 J. Biol. Chem. pmid:15507435
De La Fuente R et al. Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. 2004 Dev. Biol. pmid:15501230
Canes D et al. Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. 2005 Int. J. Cancer pmid:15499627
Spengler ML et al. Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. 2005 Cell. Signal. pmid:15494207
Emmans VC et al. Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. 2004 Biochem. Soc. Trans. pmid:15494029
Yee SB et al. Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. 2004 Int. J. Oncol. pmid:15492835
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Alcendor RR et al. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. 2004 Circ. Res. pmid:15486319
Spenger A et al. Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. 2004 Protein Expr. Purif. pmid:15477077
Li H and Wu X Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. 2004 Biochem. Biophys. Res. Commun. pmid:15474507
Ladd PD et al. Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus. 2004 Gene pmid:15474314
Vaquero A et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. 2004 Mol. Cell pmid:15469825
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Lee HS et al. Gene expression analysis in human gastric cancer cell line treated with trichostatin A and S-adenosyl-L-homocysteine using cDNA microarray. 2004 Biol. Pharm. Bull. pmid:15467184
Nan X et al. Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. 2004 Biochem. Biophys. Res. Commun. pmid:15465025
Jori FP et al. RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. 2005 Cell Death Differ. pmid:15459751
Sarg B et al. Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. 2004 J. Biol. Chem. pmid:15456746
Heltweg B et al. Subtype selective substrates for histone deacetylases. 2004 J. Med. Chem. pmid:15456267
Uramoto H et al. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. 2004 J. Cell. Sci. pmid:15454570
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Chiba T et al. Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. 2004 Oncology pmid:15452378
Zelko IN and Folz RJ Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. 2004 Free Radic. Biol. Med. pmid:15451065
Fan X et al. Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. 2004 J. Cell. Biochem. pmid:15389882
Frønsdal K and Saatcioglu F Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. 2005 Prostate pmid:15389787
Chen JS and Faller DV Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. 2005 J. Cell. Physiol. pmid:15389542
Davis FJ et al. Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15388503
Kim MK and Carroll WL Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. 2004 Cancer pmid:15382088
Laeng P et al. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. 2004 J. Neurochem. pmid:15379904
Moore PS et al. Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. 2004 Biochim. Biophys. Acta pmid:15363630
Vaghefi H and Neet KE Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. 2004 Oncogene pmid:15361854
Boehrer S et al. In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. 2004 Leuk. Lymphoma pmid:15359646
Yokota T et al. Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. 2004 FEBS Lett. pmid:15358560
Tang XX et al. Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. 2004 Clin. Cancer Res. pmid:15355914
Korkmaz CG et al. Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. 2004 J. Endocrinol. pmid:15350180
Tao D et al. Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. 2004 Acta Biochim. Biophys. Sin. (Shanghai) pmid:15346199
Cosio BG et al. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. 2004 J. Exp. Med. pmid:15337792
Liu CJ et al. Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. 2004 J. Biol. Chem. pmid:15337766
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Roh MS et al. Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. 2004 Apoptosis pmid:15314286
Facchetti F et al. Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. 2004 Apoptosis pmid:15314285
Myzak MC et al. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. 2004 Cancer Res. pmid:15313918
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Yanaihara N et al. Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. 2004 Int. J. Cancer pmid:15305387
Fishel ML et al. Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. 2005 J. Pharmacol. Exp. Ther. pmid:15304523
Tóth KF et al. Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin. 2004 J. Cell. Sci. pmid:15292402
Fenic I et al. In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. 2004 Sep-Oct J. Androl. pmid:15292114
Iijima K et al. Granulocytic differentiation of leukemic cells with t(9;11)(p22;q23) induced by all-trans-retinoic acid. 2004 Leuk. Lymphoma pmid:15291362
Joung KE et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. 2004 Arch. Pharm. Res. pmid:15283467
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Sanderson L et al. Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. 2004 Drug Metab. Dispos. pmid:15269190
Schauber J et al. Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. 2004 Mol. Immunol. pmid:15261456
Marengo E et al. Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. 2004 Anal Bioanal Chem pmid:15257427
Aggarwal BD and Calvi BR Chromatin regulates origin activity in Drosophila follicle cells. 2004 Nature pmid:15254542
Gilchrist S et al. Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. 2004 Chromosome Res. pmid:15254368
Jin B and Ryu DY Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. 2004 J. Biochem. Mol. Toxicol. pmid:15252868
Kang J et al. Synergistic killing of human leukemia cells by antioxidants and trichostatin A. 2004 Cancer Chemother. Pharmacol. pmid:15248029
De La Fuente R et al. ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. 2004 Dev. Biol. pmid:15242786
Kim JH et al. Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. 2004 Int. J. Radiat. Oncol. Biol. Phys. pmid:15234053
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Naruse Y et al. Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. 2004 Mol. Cell. Biol. pmid:15226430
Mao DY et al. Promoter-binding and repression of PDGFRB by c-Myc are separable activities. 2004 Nucleic Acids Res. pmid:15226411