Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Pampalakis G and Sotiropoulou G | Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. | 2006 | Biol. Chem. | pmid:16800739 |
Eickhoff B et al. | Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. | 2000 | Biol. Chem. | pmid:10746741 |
Steinbac OC et al. | Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus. | 2000 Sep-Oct | Biol. Chem. | pmid:11076034 |
Klan N et al. | Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. | 2003 | Biol. Chem. | pmid:12817474 |
Eickhoff B et al. | Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. | 2000 | Biol. Chem. | pmid:11154071 |
Mahmud N et al. | Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells. | 2014 | Biol. Blood Marrow Transplant. | pmid:24374212 |
Yoshida M et al. | Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. | 1995 | Bioessays | pmid:7786288 |
Gurgul A et al. | The effect of histone deacetylase inhibitor trichostatin A on porcine mesenchymal stem cell transcriptome. | 2017 | Biochimie | pmid:28552396 |
Koumbadinga GA et al. | Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. | 2015 | Biochim. Biophys. Acta | pmid:25959059 |
Donadelli M et al. | Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | 2007 | Biochim. Biophys. Acta | pmid:17555830 |
Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
Lugrin J et al. | Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. | 2009 | Biochim. Biophys. Acta | pmid:19747950 |
Kwon HS et al. | Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. | 2006 Mar-Apr | Biochim. Biophys. Acta | pmid:16757381 |
Glenisson W et al. | Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. | 2007 | Biochim. Biophys. Acta | pmid:17610967 |
Cheli Y et al. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. | 2007 Sep-Oct | Biochim. Biophys. Acta | pmid:17669516 |
Lee KJ et al. | Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter. | 2010 | Biochim. Biophys. Acta | pmid:20080132 |
Barrasa JI et al. | Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. | 2012 | Biochim. Biophys. Acta | pmid:22227581 |
Hsu YF et al. | Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22155142 |
Horvat T et al. | Epigenetic modulation of the HeLa cell membrane N-glycome. | 2012 | Biochim. Biophys. Acta | pmid:22192783 |
Zelivianski S et al. | Multipathways for transdifferentiation of human prostate cancer cells into neuroendocrine-like phenotype. | 2001 | Biochim. Biophys. Acta | pmid:11389966 |
Hsu YF et al. | p53 in trichostatin A induced C6 glioma cell death. | 2011 | Biochim. Biophys. Acta | pmid:21376104 |
Laribee RN and Klemsz MJ | Histone H4 HDAC activity is necessary for expression of the PU.1 gene. | 2005 | Biochim. Biophys. Acta | pmid:16139904 |
Chen W et al. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. | 2016 | Biochim. Biophys. Acta | pmid:27638301 |
Alcarraz-Vizán G et al. | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. | 2014 | Biochim. Biophys. Acta | pmid:24368265 |
Hsu YF et al. | MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide. | 2011 | Biochim. Biophys. Acta | pmid:21911040 |
Sharma K et al. | Constitutive hyperactivity of histone deacetylases enhances radioresistance in Lepidopteran Sf9 insect cells. | 2016 | Biochim. Biophys. Acta | pmid:26968462 |
Cui W et al. | A SUMO-acetyl switch in PXR biology. | 2016 | Biochim. Biophys. Acta | pmid:26883953 |
Gobl AE et al. | Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. | 1999 | Biochim. Biophys. Acta | pmid:10500243 |
Kusy S et al. | Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. | 2005 | Biochim. Biophys. Acta | pmid:16005989 |
Stoppani E et al. | Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature. | 2011 | Biochim. Biophys. Acta | pmid:21182936 |
Moore PS et al. | Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. | 2004 | Biochim. Biophys. Acta | pmid:15363630 |
Schnur N et al. | The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. | 2007 | Biochim. Biophys. Acta | pmid:17894944 |
Falk M et al. | Chromatin structure influences the sensitivity of DNA to gamma-radiation. | 2008 | Biochim. Biophys. Acta | pmid:18706456 |
Putnik J et al. | The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60. | 2007 | Biochim. Biophys. Acta | pmid:17980166 |
Zhao TC et al. | gp-91 mediates histone deacetylase inhibition-induced cardioprotection. | 2010 | Biochim. Biophys. Acta | pmid:20433879 |
Dowling DP et al. | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. | 2008 | Biochemistry | pmid:19053282 |
Im H et al. | Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. | 2002 | Biochemistry | pmid:12484752 |
Singh RK et al. | Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. | 2013 | Biochemistry | pmid:24079912 |
Schultz BE et al. | Kinetics and comparative reactivity of human class I and class IIb histone deacetylases. | 2004 | Biochemistry | pmid:15323567 |
Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
Kagoshima M et al. | Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. | 2003 | Biochem. Soc. Trans. | pmid:12546654 |
Liu X et al. | Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. | 2004 | Biochem. Pharmacol. | pmid:15041467 |
Ding BC et al. | Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. | 2001 | Biochem. Pharmacol. | pmid:11266651 |
Mikkelsen IM et al. | Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. | 2002 | Biochem. Pharmacol. | pmid:12123752 |
Jalonen U et al. | Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. | 2005 | Biochem. Pharmacol. | pmid:15710351 |
Park SJ et al. | Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. | 2009 | Biochem. Pharmacol. | pmid:19426671 |
Sun C and Zhou J | Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2. | 2008 | Biochem. Pharmacol. | pmid:18495085 |
Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
Vanhaecke T et al. | Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. | 2004 | Biochem. Pharmacol. | pmid:15276083 |