Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Amin HM et al. | Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). | 2001 | Br. J. Haematol. | pmid:11703323 |
Pile LA et al. | The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. | 2001 | Cell. Mol. Life Sci. | pmid:11706997 |
Sachs LM et al. | An essential role of histone deacetylases in postembryonic organ transformations in Xenopus laevis. | 2001 | Int. J. Mol. Med. | pmid:11712071 |
Lefevre P et al. | Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element. | 2001 | Nucleic Acids Res. | pmid:11713304 |
Sekita N et al. | Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines. | 2001 | Jpn. J. Cancer Res. | pmid:11572762 |
Plant KE et al. | Intergenic transcription in the human beta-globin gene cluster. | 2001 | Mol. Cell. Biol. | pmid:11533239 |
Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
Vinatzer U et al. | The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase. | 2001 | Br. J. Haematol. | pmid:11552981 |
Sekimata M et al. | Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. | 2001 | J. Biol. Chem. | pmid:11553631 |
Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
Bovenzi V and Momparler RL | Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. | 2001 | Cancer Chemother. Pharmacol. | pmid:11488527 |
Franco PJ et al. | The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. | 2001 | Mol. Endocrinol. | pmid:11463856 |
Sutherland JE et al. | The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. | 2001 | Mutat. Res. | pmid:11470494 |
Takakura M et al. | Telomerase activation by histone deacetylase inhibitor in normal cells. | 2001 | Nucleic Acids Res. | pmid:11452025 |
Ferraro M et al. | Involvement of histone H4 acetylation in the epigenetic inheritance of different activity states of maternally and paternally derived genomes in the mealybug Planococcus citri. | 2001 | Chromosoma | pmid:11453559 |
Pujuguet P et al. | Trichostatin A inhibits beta-casein expression in mammary epithelial cells. | 2001 | J. Cell. Biochem. | pmid:11746508 |
Matsusue K et al. | Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. | 2001 | DNA Cell Biol. | pmid:11749719 |
Lavelle D et al. | Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. | 2001 | Am. J. Hematol. | pmid:11754398 |
Williams RJ | Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis. | 2001 | Expert Opin Investig Drugs | pmid:11785457 |
Kim MS et al. | Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. | 2001 | Nat. Med. | pmid:11283670 |
Vigushin DM et al. | Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. | 2001 | Clin. Cancer Res. | pmid:11309348 |
Magdinier F and Wolffe AP | Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11309512 |
Grande A et al. | A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines. | 2001 | Cell Death Differ. | pmid:11313705 |
Wu Y et al. | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. | 2001 | Oncogene | pmid:11313951 |
Greenberg VL et al. | Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. | 2001 | Thyroid | pmid:11349829 |
Lea MA et al. | Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. | 2001 | Int. J. Cancer | pmid:11351296 |
Jordan A et al. | The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. | 2001 | EMBO J. | pmid:11285236 |
Bachl J et al. | Increased transcription levels induce higher mutation rates in a hypermutating cell line. | 2001 | J. Immunol. | pmid:11290786 |
Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
Ding BC et al. | Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. | 2001 | Biochem. Pharmacol. | pmid:11266651 |
Segev H et al. | Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development. | 2001 | Zygote | pmid:11358320 |
Archer SY et al. | p21 gene regulation during enterocyte differentiation. | 2001 | J. Surg. Res. | pmid:11368530 |
Ma J et al. | Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. | 2001 | Biol. Reprod. | pmid:11369600 |
Della Ragione F et al. | Genes modulated by histone acetylation as new effectors of butyrate activity. | 2001 | FEBS Lett. | pmid:11423116 |
Kosugi H et al. | In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice. | 2001 | Jpn. J. Cancer Res. | pmid:11376562 |
Arthur JL et al. | Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro. | 2001 | J. Virol. | pmid:11264377 |
Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
Taddei A et al. | Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. | 2001 | Nat. Cell Biol. | pmid:11175742 |
Ferrara FF et al. | Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. | 2001 | Cancer Res. | pmid:11196162 |
Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
Johnson CA et al. | Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. | 2001 | J. Biol. Chem. | pmid:11136718 |
Griswold MD et al. | Mechanisms involved in the homologous down-regulation of transcription of the follicle-stimulating hormone receptor gene in Sertoli cells. | 2001 | Mol. Cell. Endocrinol. | pmid:11223181 |
Mishra SK et al. | Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. | 2001 | FEBS Lett. | pmid:11682064 |
Sharma M and Sun Z | 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. | 2001 | Mol. Endocrinol. | pmid:11682623 |
Lavoie R et al. | Design and synthesis of a novel class of histone deacetylase inhibitors. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11597413 |
Bernhard D et al. | Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts. | 2001 | Cell Death Differ. | pmid:11598799 |
Hatama S et al. | Isolation and sequencing of infectious clones of feline foamy virus and a human/feline foamy virus Env chimera. | 2001 | J. Gen. Virol. | pmid:11714976 |
Yoshioka H et al. | A novel in vitro system for analyzing parental allele-specific histone acetylation in genomic imprinting. | 2001 | J. Hum. Genet. | pmid:11721881 |
He LZ et al. | Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. | 2001 | J. Clin. Invest. | pmid:11696577 |