Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Varshochi R et al. | ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. | 2005 | J. Biol. Chem. | pmid:15557281 |
Alao JP et al. | Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. | 2004 | Clin. Cancer Res. | pmid:15585645 |
Sato N et al. | Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. | 2005 | Oncogene | pmid:15592528 |
Karasawa Y and Okisaka S | Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells. | 2004 Nov-Dec | Jpn. J. Ophthalmol. | pmid:15592778 |
Davidson SM et al. | The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. | 2005 | Chembiochem | pmid:15593114 |
Goeman F et al. | Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. | 2005 | Mol. Cell. Biol. | pmid:15601862 |
Bayart E et al. | A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. | 2004 | Cancer Res. | pmid:15604258 |
Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
Fujisawa K et al. | Epigenetic status and aberrant expression of the maspin gene in human hepato-biliary tract carcinomas. | 2005 | Lab. Invest. | pmid:15608662 |
Bottardi S et al. | Onset and inheritance of abnormal epigenetic regulation in hematopoietic cells. | 2005 | Hum. Mol. Genet. | pmid:15615768 |
Ezzat S et al. | The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility. | 2005 | Mol. Endocrinol. | pmid:15618287 |
Maxhimer JB et al. | Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). | 2005 | J. Thorac. Cardiovasc. Surg. | pmid:15632825 |
Kondo T et al. | Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. | 2005 | Oncogene | pmid:15637589 |
Senawong T et al. | BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. | 2005 | Arch. Biochem. Biophys. | pmid:15639232 |
Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
Huang W et al. | Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex. | 2005 | J. Biol. Chem. | pmid:15647279 |
Choi JH et al. | Trichostatin A attenuates airway inflammation in mouse asthma model. | 2005 | Clin. Exp. Allergy | pmid:15649272 |
Kang J et al. | Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. | 2005 | Toxicol In Vitro | pmid:15649630 |
Shindo N et al. | The ESC-E(Z) complex participates in the hedgehog signaling pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15652519 |
Kemp MG et al. | The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. | 2005 | Nucleic Acids Res. | pmid:15653633 |
Huang H et al. | MEIS C termini harbor transcriptional activation domains that respond to cell signaling. | 2005 | J. Biol. Chem. | pmid:15654074 |
Danam RP et al. | Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins. | 2005 | Mol. Cancer Ther. | pmid:15657354 |
Li Y et al. | Histone deacetylation is required for progression through mitosis in tobacco cells. | 2005 | Plant J. | pmid:15659094 |
Marsili G et al. | Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659847 |
Schmittwolf C et al. | In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. | 2005 | EMBO J. | pmid:15660132 |
Endo M et al. | Novel gender-related regulation of CYP2C12 gene expression in rats. | 2005 | Mol. Endocrinol. | pmid:15661834 |
Keen JC et al. | Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells. | 2004 | Cancer Biol. Ther. | pmid:15662126 |
Sengupta S et al. | Tumor suppressor p53 represses transcription of RECQ4 helicase. | 2005 | Oncogene | pmid:15674334 |
Busson M et al. | Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. | 2005 | Oncogene | pmid:15674337 |
Ding W | [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]. | 2004 | Hokkaido Igaku Zasshi | pmid:15675303 |
Wen J et al. | Tal1/SCL binding to pericentromeric DNA represses transcription. | 2005 | J. Biol. Chem. | pmid:15677454 |
Yamashita Y et al. | cDNA microarray analysis in hepatocyte differentiation in Huh 7 cells. | 2004 | Cell Transplant | pmid:15690981 |
Zhao Y et al. | Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. | 2005 | J. Exp. Biol. | pmid:15695762 |
Illi B et al. | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. | 2005 | Circ. Res. | pmid:15705964 |
Jalonen U et al. | Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. | 2005 | Biochem. Pharmacol. | pmid:15710351 |
Hooven LA et al. | Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713371 |
Chen B et al. | Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713393 |
Duan H et al. | Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. | 2005 | Mol. Cell. Biol. | pmid:15713621 |
Tong X et al. | Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. | 2005 | J. Biol. Chem. | pmid:15713675 |
Gan Y et al. | Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. | 2005 | J. Biol. Chem. | pmid:15722551 |
Endo T et al. | Changes in histone modifications during in vitro maturation of porcine oocytes. | 2005 | Mol. Reprod. Dev. | pmid:15736133 |
Emionite L et al. | Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | 2004 Nov-Dec | Anticancer Res. | pmid:15736447 |
Fan S et al. | Valproic acid enhances gene expression from viral gene transfer vectors. | 2005 | J. Virol. Methods | pmid:15737413 |
Sonnemann J et al. | Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. | 2005 | Invest New Drugs | pmid:15744585 |
ChuÄkin IA et al. | [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. | 2004 | Tsitologiia | pmid:15747838 |
Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |
Hu J and Colburn NH | Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. | 2005 | Mol. Cancer Res. | pmid:15755876 |
Wagner S and Roemer K | Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. | 2005 | Biochem. Pharmacol. | pmid:15763542 |
Kawamura T et al. | Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. | 2005 | J. Biol. Chem. | pmid:15764815 |
Dote H et al. | Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. | 2005 | Br. J. Cancer | pmid:15770214 |
Laberge RM and Boissonneault G | On the nature and origin of DNA strand breaks in elongating spermatids. | 2005 | Biol. Reprod. | pmid:15772260 |
McKenzie GJ et al. | Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. | 2005 | J. Neurochem. | pmid:15773917 |
Subramanian C et al. | Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15778293 |
Lu ZP et al. | Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15781251 |
Nishigaki M et al. | Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. | 2005 | Cancer Res. | pmid:15781621 |
Bai J et al. | Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. | 2005 | Cancer Res. | pmid:15781649 |
Rahmani M et al. | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. | 2005 | Cancer Res. | pmid:15781658 |
Frescas D et al. | Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. | 2005 | J. Biol. Chem. | pmid:15788402 |
Li X et al. | Regulation of histone acetylation and apoptosis by trichostatin in HL-60 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15791844 |
Kang J et al. | Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. | 2005 | Biochem. Pharmacol. | pmid:15794941 |
Narayanan R et al. | Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. | 2005 | Mol. Cell. Biol. | pmid:15798179 |
Xiong Y et al. | Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. | 2005 | Cancer Res. | pmid:15805266 |
Kumakura S et al. | Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. | 2005 | Cancer Res. | pmid:15805278 |
Zhao W et al. | The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. | 2005 | J. Biochem. | pmid:15809347 |
Komata T et al. | Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. | 2005 | Int. J. Oncol. | pmid:15809727 |
Blais M et al. | Synergy between deacetylase inhibitors and IL-1beta in activation of the serum amyloid A2 gene promoter. | 2005 | DNA Cell Biol. | pmid:15812237 |
Young DA et al. | Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. | 2005 | FEBS J. | pmid:15819885 |
Xu S et al. | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 2005 | J. Hum. Genet. | pmid:15824892 |
Strait KA et al. | Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. | 2005 | Mol. Cancer Ther. | pmid:15827334 |
Magner WJ and Tomasi TB | Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. | 2005 | Mol. Immunol. | pmid:15829293 |
Gonçalves J et al. | Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells. | 2005 | Clin. Chem. Lab. Med. | pmid:15843208 |
Robbins AR et al. | Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin. | 2005 | Cell Cycle | pmid:15846093 |
Taghiyev AF et al. | Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment. | 2005 | Cancer Biol. Ther. | pmid:15846101 |
Barki-Celli L et al. | Differences in nuclear positioning of 1q12 pericentric heterochromatin in normal and tumor B lymphocytes with 1q rearrangements. | 2005 | Genes Chromosomes Cancer | pmid:15846776 |
Song Y et al. | [The mechanisms of p21WAF1/Cip-1 expression in MOLT-4 cell line induced by TSA]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854272 |
Xu ZM et al. | [Analysis of the methylation in the promoter of LRP15 gene and its expression]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854274 |
Mai A et al. | Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. | 2005 | J. Med. Chem. | pmid:15857140 |
Galfi P et al. | Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862948 |
Choi KH et al. | Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine. | 2005 | Glycoconj. J. | pmid:15864436 |
Touma SE et al. | Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. | 2005 | Clin. Cancer Res. | pmid:15867260 |
Fish JE et al. | The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. | 2005 | J. Biol. Chem. | pmid:15870070 |
Dyson MH et al. | MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. | 2005 | J. Cell. Sci. | pmid:15870105 |
Reid G et al. | Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. | 2005 | Oncogene | pmid:15870696 |
Kim MS et al. | Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). | 2005 | Exp. Cell Res. | pmid:15878336 |
Rosenqvist N et al. | Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain. | 2005 | Cell Transplant | pmid:15881422 |
Camelo S et al. | Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. | 2005 | J. Neuroimmunol. | pmid:15885809 |
Peltonen K et al. | Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. | 2005 | Pigment Cell Res. | pmid:15892716 |
Schwahn DJ et al. | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. | 2005 | Pigment Cell Res. | pmid:15892717 |
Ho WC et al. | Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. | 2005 | Cancer Res. | pmid:15899819 |
Tran T et al. | Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. | 2005 | Cancer Res. | pmid:15899836 |
Gurvich N et al. | Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. | 2005 | FASEB J. | pmid:15901671 |
Ranganathan P and Rangnekar VM | Exploiting the TSA connections to overcome apoptosis-resistance. | 2005 | Cancer Biol. Ther. | pmid:15908800 |
Rincón-Arano H et al. | YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. | 2005 | J. Mol. Biol. | pmid:15913647 |
Law RD and Suttle JC | Chromatin remodeling in plant cell culture: patterns of DNA methylation and histone H3 and H4 acetylation vary during growth of asynchronous potato cell suspensions. | 2005 | Plant Physiol. Biochem. | pmid:15922608 |
Seo H et al. | Rapid generation of specific antibodies by enhanced homologous recombination. | 2005 | Nat. Biotechnol. | pmid:15924134 |
Gray SG et al. | Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. | 2005 | J. Biol. Chem. | pmid:15927959 |
Gunin AG et al. | Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. | 2005 | J. Endocrinol. | pmid:15930180 |
Wittich S et al. | Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines. | 2005 | Anticancer Drugs | pmid:15930892 |