trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mazzio EA and Soliman KFA | Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. | Cancer Genomics Proteomics | pmid:30194076 | |
| Rahimian A et al. | [Inhibition of Histone Deacetylases Reverses Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells through a Slug Mediated Mechanism]. | Mol. Biol. (Mosk.) | pmid:29989579 | |
| pmid: | ||||
| Shin S et al. | Trichostatin A Sensitizes Hepatocellular Carcinoma Cells to Enhanced NK Cell-mediated Killing by Regulating Immune-related Genes. | Cancer Genomics Proteomics | pmid:28871002 | |
| Yoshida M et al. | Effects of trichostatins on differentiation of murine erythroleukemia cells. | 1987 | Cancer Res. | pmid:2439196 |
| Corelli F et al. | [Antibacterial and antifungal compounds. VIII. Synthesis and antifungal activity of pyrrol derivatives similar to trichostatin A]. | 1987 | Farmaco Sci | pmid:3329612 |
| Yoshida M and Beppu T | Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A. | 1988 | Exp. Cell Res. | pmid:3134246 |
| Otoguro K et al. | Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A. | 1988 | J. Antibiot. | pmid:3372352 |
| Yoshida M and Beppu T | [Trichostatins and leptomycins, new cell cycle inhibitors specific for G1 and G2 phases]. | 1989 | Tanpakushitsu Kakusan Koso | pmid:2678278 |
| Yoshida M et al. | Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells. | 1990 | J. Antibiot. | pmid:2211374 |
| Yoshida M et al. | Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. | 1990 | J. Biol. Chem. | pmid:2211619 |
| Massa S et al. | Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogues of trichostatin A. | 1990 | J. Med. Chem. | pmid:2213836 |
| [Isolation of drug-resistant mutant cells]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1745788 | |
| Sugita K et al. | Morphological reversion of sis-transformed NIH3T3 cells by trichostatin A. | 1992 | Cancer Res. | pmid:1727377 |
| Sugita K et al. | A novel compound, depudecin, induces production of transformation to the flat phenotype of NIH3T3 cells transformed by ras-oncogene. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1731795 |
| Kijima M et al. | Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. | 1993 | J. Biol. Chem. | pmid:8226751 |
| Almouzni G et al. | Histone acetylation influences both gene expression and development of Xenopus laevis. | 1994 | Dev. Biol. | pmid:7958429 |
| Miyashita T et al. | Activation of the mouse cytokeratin A (endo A) gene in teratocarcinoma F9 cells by the histone deacetylase inhibitor Trichostatin A. | 1994 | FEBS Lett. | pmid:7523197 |
| Kimura M et al. | Dual modes of action of platelet-derived growth factor and its inhibition by trichostatin-A for DNA synthesis in primary cultured smooth muscle cells of rat aorta. | 1994 | Biol. Pharm. Bull. | pmid:8019505 |
| Sanchez del Pino MM et al. | Properties of the yeast nuclear histone deacetylase. | 1994 | Biochem. J. | pmid:7980438 |
| Hoshikawa Y et al. | Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. | 1994 | Exp. Cell Res. | pmid:8082721 |
| Girardot V et al. | Relationship between core histone acetylation and histone H1(0) gene activity. | 1994 | Eur. J. Biochem. | pmid:7925412 |
| Thompson EM et al. | Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7877974 |
| Futamura M et al. | Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells. | 1995 | Oncogene | pmid:7700637 |
| Okabe M et al. | Competence effect of PDGF on Ki-67 antigen and DNA contents, and its inhibition by trichostatin-A and a butylydene phthalide BP-421 in primary smooth muscle cells of rat aorta by flow cytometry. | 1995 | Biol. Pharm. Bull. | pmid:8787785 |
| Worrad DM et al. | Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo. | 1995 | Development | pmid:7555721 |
| Yoshida M et al. | Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. | 1995 | Bioessays | pmid:7786288 |
| O'Neill LP and Turner BM | Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner. | 1995 | EMBO J. | pmid:7664735 |
| Arts J et al. | Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation. | 1995 | Biochem. J. | pmid:7646441 |
| Lee E et al. | Involvement of histone hyperacetylation in triggering DNA fragmentation of rat thymocytes undergoing apoptosis. | 1996 | FEBS Lett. | pmid:8898091 |
| Taunton J et al. | A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. | 1996 | Science | pmid:8602529 |
| Van Lint C et al. | Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. | 1996 | EMBO J. | pmid:8605881 |
| Carmen AA et al. | HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. | 1996 | J. Biol. Chem. | pmid:8663039 |
| Van Lint C et al. | The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. | 1996 | Gene Expr. | pmid:8723390 |
| Takahashi I et al. | Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase. | 1996 | J. Antibiot. | pmid:8682722 |
| Zhang J et al. | Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line. | 1996 | Mol. Pharmacol. | pmid:8967965 |
| Yoshida M | [Molecular targets of cell cycle inhibitors and their mode of action]. | 1996 | Tanpakushitsu Kakusan Koso | pmid:8890633 |
| Sano M and Kitajima S | Inhibition of the nerve growth factor-induced outgrowth of neurites by trichostatin A requires protein synthesis de novo in PC12D cells. | 1996 | Brain Res. | pmid:9117395 |
| Bartsch J et al. | Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8855250 |
| Ogryzko VV et al. | Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. | 1996 | Mol. Cell. Biol. | pmid:8756678 |
| Yamamoto I et al. | Histone hyperacetylation plays a role in augmentation of IL-4-induced IgE production in LPS-stimulated murine B-lymphocytes by sodium butyrate. | 1996 | J. Biochem. | pmid:8827437 |
| McBain JA et al. | Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. | 1997 | Biochem. Pharmacol. | pmid:9214697 |
| Ohno Y et al. | Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9294201 |
| Huang N et al. | Inhibition of IL-8 gene expression in Caco-2 cells by compounds which induce histone hyperacetylation. | 1997 | Cytokine | pmid:9067093 |
| Garcia-Villalba P et al. | Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression. | 1997 | DNA Cell Biol. | pmid:9150429 |
| Chen WY et al. | Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9159154 |
| Sowa Y et al. | Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9405248 |
| Sheridan PL et al. | Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. | 1997 | Genes Dev. | pmid:9407026 |
| Minucci S et al. | A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9326603 |
| Ekwall K et al. | Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. | 1997 | Cell | pmid:9428524 |
| Xu L et al. | Effect of the histone deacetylase inhibitor trichostatin A on the responsiveness of rat hepatocytes to dioxin. | 1997 | Biochem. Pharmacol. | pmid:9174108 |
| Stein P et al. | Stage-dependent redistributions of acetylated histones in nuclei of the early preimplantation mouse embryo. | 1997 | Mol. Reprod. Dev. | pmid:9211426 |
| Sommer A et al. | Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity. | 1997 | Curr. Biol. | pmid:9197243 |
| Jenster G et al. | Steroid receptor induction of gene transcription: a two-step model. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9223281 |
| Nagy L et al. | Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. | 1997 | Cell | pmid:9150137 |
| Goldman MA | Executive decision: chromatin structure and gene regulation. | 1997 | Trends Genet. | pmid:9351338 |
| Dion LD et al. | Amplification of recombinant adenoviral transgene products occurs by inhibition of histone deacetylase. | 1997 | Virology | pmid:9168882 |
| Chen ZJ and Pikaard CS | Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance. | 1997 | Genes Dev. | pmid:9284051 |
| Medina V et al. | Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. | 1997 | Cancer Res. | pmid:9288776 |
| Koguchi Y et al. | Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor. | 1997 | J. Antibiot. | pmid:9592573 |
| Dangond F and Gullans SR | Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647779 |
| Lin RJ et al. | Role of the histone deacetylase complex in acute promyelocytic leukaemia. | 1998 | Nature | pmid:9486654 |
| Grignani F et al. | Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. | 1998 | Nature | pmid:9486655 |
| Wong J et al. | Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. | 1998 | EMBO J. | pmid:9430643 |
| Komatsu Y and Hayashi H | Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells. | 1998 | J. Antibiot. | pmid:9531994 |
| Magnaghi-Jaulin L et al. | Retinoblastoma protein represses transcription by recruiting a histone deacetylase. | 1998 | Nature | pmid:9468140 |
| Svensson K et al. | The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. | 1998 | Development | pmid:9389664 |
| Emiliani S et al. | Characterization of a human RPD3 ortholog, HDAC3. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501169 |
| El Kharroubi A et al. | Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. | 1998 | Mol. Cell. Biol. | pmid:9566873 |
| Gray SG and Ekström TJ | Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9571167 |
| Belyaev ND et al. | The acetylation patterns of histones H3 and H4 along Vicia faba chromosomes are different. | 1998 | Chromosome Res. | pmid:9510512 |
| Nan X et al. | Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. | 1998 | Nature | pmid:9620804 |
| Kim YB et al. | phd1+, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A. | 1998 | FEBS Lett. | pmid:9781677 |
| Richon VM et al. | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501205 |
| Egawa K et al. | Identification of active substances from Streptomyces culture fluids using p53-independent expression of p21/WAF1/Cip1 gene and their mode of action. | 1998 | Biol. Pharm. Bull. | pmid:9781835 |
| Kohge T et al. | Promotion of antigen-specific antibody production in murine B cells by a moderate increase in histone acetylation. | 1998 | Biochem. Pharmacol. | pmid:9825735 |
| Grewal SI et al. | Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. | 1998 | Genetics | pmid:9755190 |
| Preston CM and McFarlane M | Cytodifferentiating agents affect the replication of herpes simplex virus type 1 in the absence of functional VP16. | 1998 | Virology | pmid:9791032 |
| Hu JF et al. | The role of histone acetylation in the allelic expression of the imprinted human insulin-like growth factor II gene. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792787 |
| Llorente A et al. | Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus. | 1998 | J. Cell Biol. | pmid:9456316 |
| Korhonen P et al. | Expression of transcriptional repressor protein mSin3A but not mSin3B is induced during neuronal apoptosis. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9813182 |
| Waterborg JH | Dynamics of histone acetylation in Chlamydomonas reinhardtii. | 1998 | J. Biol. Chem. | pmid:9765294 |
| Madisen L et al. | The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. | 1998 | Mol. Cell. Biol. | pmid:9774645 |
| Eden S et al. | DNA methylation models histone acetylation. | 1998 | Nature | pmid:9732866 |
| Phelan MW et al. | Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells. | 1998 | J. Lab. Clin. Med. | pmid:9851743 |
| Ciana P et al. | Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo. | 1998 | EMBO J. | pmid:9857194 |
| De Luca P et al. | Retinoblastoma protein tethered to promoter DNA represses TBP-mediated transcription. | 1998 | J. Cell. Biochem. | pmid:9671233 |
| Selker EU | Trichostatin A causes selective loss of DNA methylation in Neurospora. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689097 |
| Jin S and Scotto KW | Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. | 1998 | Mol. Cell. Biol. | pmid:9632821 |
| Nakajima H et al. | FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. | 1998 | Exp. Cell Res. | pmid:9633520 |
| Thompson EM and Renard JP | Preferential nuclear location of a transgene does not depend on its transcriptional activity during early mouse development. | 1998 | Chromosoma | pmid:9880765 |
| Durum SK et al. | Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. | 1998 | J. Exp. Med. | pmid:9858510 |
| Nemer M | Histone deacetylase mRNA temporally and spatially regulated in its expression in sea urchin embryos. | 1998 | Dev. Growth Differ. | pmid:9865968 |
| Ishiguro K and Sartorelli AC | Coinduction of embryonic and adult-type globin mRNAs by sodium butyrate and trichostatin A in two murine interleukin-3-dependent bone marrow-derived cell lines. | 1998 | Blood | pmid:9834245 |
| Walia H et al. | Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA. | 1998 | J. Biol. Chem. | pmid:9603965 |
| Bakin AV and Curran T | Role of DNA 5-methylcytosine transferase in cell transformation by fos. | 1999 | Science | pmid:9888853 |
| Carmen AA et al. | Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10535926 |
| Rüller S et al. | Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. | 1999 | Clin. Cancer Res. | pmid:10537334 |
| Vanden Berghe W et al. | The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. | 1999 | J. Biol. Chem. | pmid:10542243 |
| Ng HH et al. | MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. | 1999 | Nat. Genet. | pmid:10471499 |