Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sourlingas TG et al. | Histone deacetylase inhibitors induce apoptosis in peripheral blood lymphocytes along with histone H4 acetylation and the expression of the linker histone variant, H1 degrees. | 2001 | Eur. J. Cell Biol. | pmid:11824792 |
Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. | 2001 | Brain Tumor Pathol | pmid:11908866 |
Nair AR et al. | Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. | 2001 | Cancer Lett. | pmid:11295287 |
Hatama S et al. | Reactivation of feline foamy virus from a chronically infected feline renal cell line by trichostatin A. | 2001 | Virology | pmid:11336556 |
Viollet B et al. | Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes. | 2001 | Mol. Cell. Biol. | pmid:11340160 |
Nakamura M et al. | Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor. | 2001 | J. Cell. Physiol. | pmid:11319763 |
Xu D et al. | Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11274400 |
Seth KA and Majzoub JA | Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. | 2001 | J. Biol. Chem. | pmid:11278361 |
Matsuda E et al. | Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms. | 2001 | J. Biol. Chem. | pmid:11278721 |
Kim MS et al. | Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. | 2001 | Nat. Med. | pmid:11283670 |
Harada Y et al. | A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11396961 |
Yang H et al. | Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11208539 |
Chen C et al. | Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites. | 2001 | J. Biol. Chem. | pmid:11013250 |
Ullerås E et al. | Inhibition of histone deacetylase activity causes cell type-specific induction of the PDGF-B promoter only in the absence of activation by its enhancer. | 2001 | Exp. Cell Res. | pmid:11640883 |
Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |
Muth V et al. | Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. | 2001 | EMBO J. | pmid:11250901 |
Laribee RN and Klemsz MJ | Loss of PU.1 expression following inhibition of histone deacetylases. | 2001 | J. Immunol. | pmid:11673528 |
Biade S et al. | Chemical agents that promote chromatin compaction radiosensitize tumour cells. | 2001 | Int. J. Radiat. Biol. | pmid:11682008 |
Mishra SK et al. | Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. | 2001 | FEBS Lett. | pmid:11682064 |
Sharma M and Sun Z | 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription. | 2001 | Mol. Endocrinol. | pmid:11682623 |