trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Fibrosis D005355 23 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Stroke D020521 32 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Translocation, Genetic D014178 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Radiation Injuries D011832 14 associated lipids
Leishmaniasis D007896 19 associated lipids
Enteritis D004751 8 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Osteomalacia D010018 5 associated lipids
Glioblastoma D005909 27 associated lipids
Keloid D007627 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Medulloblastoma D008527 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Cat Diseases D002371 12 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Retinoblastoma D012175 12 associated lipids
Genomic Instability D042822 7 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Mastocytoma D034801 3 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Shi LH et al. Trichostatin A and nuclear reprogramming of cloned rabbit embryos. 2008 J. Anim. Sci. pmid:18245503
Hou W et al. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. 2012 Nov-Dec J. Androl. pmid:22556385
Fenic I et al. In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis. 2008 Mar-Apr J. Androl. pmid:18046049
Fenic I et al. In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. 2004 Sep-Oct J. Androl. pmid:15292114
Yoshikawa M et al. Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. 2007 J. Am. Soc. Nephrol. pmid:17135397
Yu Z et al. Histone deacetylases augment cytokine induction of the iNOS gene. 2002 J. Am. Soc. Nephrol. pmid:12138131
Ren C et al. Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. 2005 J. Am. Soc. Mass Spectrom. pmid:16099169
Kudo K et al. Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. 2017 J. Am. Chem. Soc. pmid:28497964
Milagre I et al. Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. 2010 J. Alzheimers Dis. pmid:20930312
Valapour M et al. Histone deacetylation inhibits IL4 gene expression in T cells. 2002 J. Allergy Clin. Immunol. pmid:11842291
Su RC et al. Epigenetic regulation of established human type 1 versus type 2 cytokine responses. 2008 J. Allergy Clin. Immunol. pmid:17980413
Simões-Pires CA et al. Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. 2017 J Vis Exp pmid:28829415
Azuma R et al. Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer. 2018 J Vis Exp pmid:29757287
Kimura T et al. Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. 2011 J Toxicol Sci pmid:21467744
Albertus DL et al. AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. 2008 J Thorac Oncol pmid:18978557
Seo SK et al. Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. 2011 J Thorac Oncol pmid:21642861
Selinger CI et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. 2011 J Thorac Oncol pmid:21597389
Kakihana M et al. Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition. 2009 J Thorac Oncol pmid:20009910
Gavin DP et al. Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. 2009 J Psychiatry Neurosci pmid:19448855
Gavin DP et al. Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. 2009 J Psychiatr Res pmid:19187942
Sun G et al. Insights into the lysine acetylproteome of human sperm. 2014 J Proteomics pmid:25038526
Por ED et al. Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. 2016 J Ocul Pharmacol Ther pmid:27494828
Noro R et al. The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application. 2009 J Nippon Med Sch pmid:19305113
Fleiss B et al. Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. 2012 J Neuroinflammation pmid:22512781
Suh HS et al. Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes. 2010 J Neuroimmune Pharmacol pmid:20157787
Bence M et al. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. 2012 J Neural Transm pmid:21785940
Wang H et al. Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. 2012 J Neural Transm pmid:22407380
Klawitter M et al. Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. 2011 J Negat Results Biomed pmid:21801383
Mastitskaya S and Denecke B Human spongiosa mesenchymal stem cells fail to generate cardiomyocytes in vitro. 2009 J Negat Results Biomed pmid:19903342
Bar-Nur O et al. Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives. 2012 J Mol Cell Biol pmid:22430918
Zou Y et al. Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia. 2012 J Hematol Oncol pmid:22747680
Tischler JL et al. Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors. 2008 J Enzyme Inhib Med Chem pmid:18608778
Duncan HF et al. Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. 2012 J Endod pmid:22341071
Wu Y et al. Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. 2017 J Diabetes Res pmid:28191472
Marengo E et al. Use of Legendre moments for the fast comparison of two-dimensional polyacrylamide gel electrophoresis maps images. 2005 J Chromatogr A pmid:16301071
Zhao W et al. A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. 2015 J Chin Med Assoc pmid:25913212
Jang B et al. Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones. 2018 J Cancer Res Ther pmid:30249871
Hutz JE et al. The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens. 2013 J Biomol Screen pmid:23204073
Chen MH et al. A new trichostatin analog from Streptomyces sp. CPCC 203909. 2015 J Asian Nat Prod Res pmid:25977996
Schwechter BR et al. Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17525221
Li H et al. Epigenetic regulation of CXCR4 expression by the ocular microenvironment. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23188729
Kashiwagi Y et al. Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines. 2010 Invest. Ophthalmol. Vis. Sci. pmid:19737884
Crosson CE et al. Inhibition of histone deacetylase protects the retina from ischemic injury. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20164449
Wood JP et al. A comparison of differentiation protocols for RGC-5 cells. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20181845
Wallace DM et al. Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16799012
Wang J et al. Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20089874
Xie L et al. Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition. 2014 Invest. Ophthalmol. Vis. Sci. pmid:24994865
Klisovic DD et al. Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12766035
Robertson DM et al. C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells. 2010 Invest. Ophthalmol. Vis. Sci. pmid:20375332
Fan J et al. Inhibition of HDAC2 protects the retina from ischemic injury. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23696608
Sharma A et al. Trichostatin a inhibits corneal haze in vitro and in vivo. 2009 Invest. Ophthalmol. Vis. Sci. pmid:19168895
Sonnemann J et al. Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. 2005 Invest New Drugs pmid:15744585
Fraczek J et al. Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. 2009 Invest New Drugs pmid:18825314
Li GC et al. Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. 2006 Int. J. Urol. pmid:16771729
Sah NK et al. Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. 2006 Int. J. Radiat. Oncol. Biol. Phys. pmid:17011457
Kim JH et al. Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. 2004 Int. J. Radiat. Oncol. Biol. Phys. pmid:15234053
Kumar A et al. γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. 2011 Int. J. Radiat. Biol. pmid:21815748
Biade S et al. Chemical agents that promote chromatin compaction radiosensitize tumour cells. 2001 Int. J. Radiat. Biol. pmid:11682008
Byers J and Eichinger D Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. 2008 Int. J. Parasitol. pmid:17706222
Takahashi K et al. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. 2006 Int. J. Oncol. pmid:16391785
Bai T et al. A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. 2006 Int. J. Oncol. pmid:16391806
Hong X et al. Heparanase expression is associated with histone modifications in glioblastoma. 2012 Int. J. Oncol. pmid:22001963
Kadaja-Saarepuu L et al. Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. 2012 Int. J. Oncol. pmid:21947346
You BR and Park WH Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. 2013 Int. J. Oncol. pmid:23165748
Gray SG et al. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. 2004 Int. J. Oncol. pmid:15010814
Sato K et al. Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. 2006 Int. J. Oncol. pmid:16820886
Torres J et al. Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas. 2010 Int. J. Oncol. pmid:20811720
Meng F et al. Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. 2013 Int. J. Oncol. pmid:23709006
Zhou C et al. Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. 2006 Int. J. Oncol. pmid:16773209
Gahr S et al. The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. 2007 Int. J. Oncol. pmid:17671683
Yee SB et al. Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. 2004 Int. J. Oncol. pmid:15492835
Al-Nakhle H et al. Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. 2013 Int. J. Oncol. pmid:24068253
Yamanegi K et al. Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. 2015 Int. J. Oncol. pmid:25778932
Kang KA et al. Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. 2013 Int. J. Oncol. pmid:24100442
Meli M et al. Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. 2011 Int. J. Oncol. pmid:21318222
Imesch P et al. MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. 2009 Int. J. Oncol. pmid:19639184
Fortson WS et al. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. 2011 Int. J. Oncol. pmid:21519790
Thelen P et al. Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. 2004 Int. J. Oncol. pmid:14654937
Li QQ et al. Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. 2016 Int. J. Oncol. pmid:27082124
Komata T et al. Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. 2005 Int. J. Oncol. pmid:15809727
Rho JH et al. Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. 2005 Int. J. Oncol. pmid:16010429
Choi YH Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. 2005 Int. J. Oncol. pmid:16010430
Noro R et al. PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. 2007 Int. J. Oncol. pmid:17912443
Svechnikova I et al. HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. 2008 Int. J. Oncol. pmid:18360709
Asgar MA et al. Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. 2016 Int. J. Oncol. pmid:26575528
Stapnes C et al. Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. 2007 Int. J. Oncol. pmid:17982680
Carlisi D et al. Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. 2008 Int. J. Oncol. pmid:18097557
Park WH et al. Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. 2003 Int. J. Oncol. pmid:12684681
Sonnemann J et al. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. 2006 Int. J. Oncol. pmid:16465382
Lee EJ et al. Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. 2008 Int. J. Oncol. pmid:18813790
Ma XH et al. Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. 2015 Int. J. Neurosci. pmid:24730998
Qiang M et al. Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. 2014 Int. J. Neuropsychopharmacol. pmid:25522411
Sakharkar AJ et al. Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. 2014 Int. J. Neuropsychopharmacol. pmid:24528596
Park H et al. Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. 2008 Int. J. Mol. Med. pmid:18949380
Inoue H et al. Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. 2002 Int. J. Mol. Med. pmid:11956660
Ma J et al. Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. 2012 Int. J. Mol. Med. pmid:22992863
Andoh A et al. Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. 2000 Int. J. Mol. Med. pmid:10851266
Guo Y et al. Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. 2017 Int. J. Mol. Med. pmid:28849190
Fukuoka M et al. Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. 2003 Int. J. Mol. Med. pmid:12964026
Hoever G et al. The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. 2003 Int. J. Mol. Med. pmid:12736716