trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Fibrosis D005355 23 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Stroke D020521 32 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Translocation, Genetic D014178 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Radiation Injuries D011832 14 associated lipids
Leishmaniasis D007896 19 associated lipids
Enteritis D004751 8 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Osteomalacia D010018 5 associated lipids
Glioblastoma D005909 27 associated lipids
Keloid D007627 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Medulloblastoma D008527 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Cat Diseases D002371 12 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Retinoblastoma D012175 12 associated lipids
Genomic Instability D042822 7 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Mastocytoma D034801 3 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Anderson L et al. Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni. 2017 PLoS Negl Trop Dis pmid:28406899
Shao G et al. Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation. 2017 Oncol. Rep. pmid:28393191
Chang YW and Singh KP Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells. 2017 PLoS ONE pmid:28323900
Lin S et al. Silencing of ATP4B of ATPase H/K Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. 2017 Oncol. Res. pmid:28281974
Li LF et al. Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. 2017 PLoS ONE pmid:28234968
Wisnieski F et al. BMP8B Is a Tumor Suppressor Gene Regulated by Histone Acetylation in Gastric Cancer. 2017 J. Cell. Biochem. pmid:27748538
Ladrech S et al. High mobility group box 1 (HMGB1): dual functions in the cochlear auditory neurons in response to stress? 2017 Histochem. Cell Biol. pmid:27704212
Mijiddorj T et al. Retinoic acid and retinaldehyde dehydrogenase are not involved in the specific induction of the follicle-stimulating hormone β subunit by trichostatin A, a selective inhibitor of histone deacetylase. 2017 Gen. Comp. Endocrinol. pmid:26654743
Kim YH and Lee JK Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. 2017 Cell. Immunol. pmid:28341057
Choi SA et al. A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma. 2017 Oncotarget pmid:27852054
Pinz S and Rascle A Assessing HDAC Function in the Regulation of Signal Transducer and Activator of Transcription 5 (STAT5) Activity Using Chromatin Immunoprecipitation (ChIP). 2017 Methods Mol. Biol. pmid:27761827
Buchou T et al. Purification and Analysis of Male Germ Cells from Adult Mouse Testis. 2017 Methods Mol. Biol. pmid:27761820
Unruhe-Knauf B and Knauer SK Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization. 2017 Methods Mol. Biol. pmid:27761812
Kotantaki P and Mosialos G The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. 2016 Cell Biochem. Funct. pmid:27570065
Li L et al. In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. 2016 PLoS ONE pmid:26900852
Lim SY et al. Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. 2016 Methods Mol. Biol. pmid:25520285
Dai Q et al. Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. 2016 Acta Pharmacol. Sin. pmid:26775659
Shao A et al. Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. 2016 Mol. Neurobiol. pmid:25399954
Hou X et al. Histone deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma. 2016 Clin Respir J pmid:25307458
Rong X et al. Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. 2016 Sci Rep pmid:27703255
Pallocca G et al. Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. 2016 Arch. Toxicol. pmid:26705709
Li X et al. Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. 2016 Toxicol. Appl. Pharmacol. pmid:27396813
Robert C et al. Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. 2016 Leuk. Res. pmid:27064363
Mohammadi-Bardbori A et al. Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling. 2016 Chem. Biol. Interact. pmid:27041069
Li W et al. Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1. 2016 Chem. Res. Toxicol. pmid:26991801
Wu TC et al. The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. 2016 Toxicol. Appl. Pharmacol. pmid:26768552
Zhang Y and Zhang B Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. 2016 J. Biochem. Mol. Toxicol. pmid:26509796
Contreras-Leal E et al. Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. 2016 Mol. Carcinog. pmid:26331238
Díaz-Núñez M et al. Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. 2016 BMC Cancer pmid:27549189
Bricambert J et al. Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. 2016 Mol Metab pmid:27900262
Adachi T et al. Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment. 2016 Arch. Biochem. Biophys. pmid:27470189
Deng Z et al. Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. 2016 Int. J. Biol. Sci. pmid:27877082
Kim HR et al. Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. 2016 PLoS ONE pmid:27855185
Tombolan L et al. Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. 2016 BMC Cancer pmid:27842508
Tao W et al. Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. 2016 Neuroscience pmid:27646288
Chen W et al. MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. 2016 Biochim. Biophys. Acta pmid:27638301
Bauer I et al. A Class 1 Histone Deacetylase with Potential as an Antifungal Target. 2016 MBio pmid:27803184
Xu Q et al. Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:27638876
Nadanaka S et al. Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. 2016 Biochem. Biophys. Res. Commun. pmid:27751852
Tiper IV and Webb TJ Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. 2016 Cancer Immunol. Immunother. pmid:27614429
Desjardins D et al. Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. 2016 PLoS ONE pmid:27617745
Park IH et al. Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. 2016 PLoS ONE pmid:27571418
Sugiyama KI et al. Epigenetic mutagen as histone modulator can be detected by yeast flocculation. 2016 Mutagenesis pmid:27549112
Zhang XF et al. Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. 2016 Int J Mol Sci pmid:27548148
Scholpa NE et al. Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. 2016 Chem. Biol. Interact. pmid:27543423
Hou Y et al. Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. 2016 Neurosci Bull pmid:27522594
Huang H et al. Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. 2016 Cell. Mol. Immunol. pmid:25683610
Wang S et al. Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. 2016 Cytokine pmid:27500645
Por ED et al. Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. 2016 J Ocul Pharmacol Ther pmid:27494828
Liu Y et al. DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac. 2016 J. Exp. Clin. Cancer Res. pmid:27461117
Feng Q et al. Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation. 2016 Int. J. Mol. Med. pmid:27460781
Miyake Y et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. 2016 Nat. Chem. Biol. pmid:27454931
Li C et al. PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells. 2016 Acta Biochim. Biophys. Sin. (Shanghai) pmid:27451443
Igaz N et al. Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. 2016 Colloids Surf B Biointerfaces pmid:27434153
Qu H et al. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. 2016 Mol Med Rep pmid:27431944
Choi SY et al. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. 2016 J. Cell. Mol. Med. pmid:27420561
Dhoke NR et al. Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. 2016 Stem Cell Res pmid:27394013
Drzewiecka H et al. Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. 2016 J. Cancer Res. Clin. Oncol. pmid:27393180
Zhang NH et al. Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. 2016 Oncol. Rep. pmid:27373420
Chang I and Wang CY Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. 2016 J. Biol. Chem. pmid:27369083
Yagi K et al. Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. 2016 Crit. Care Med. pmid:27352127
Wei L et al. Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. 2016 Brain Res. pmid:27312092
Du R et al. Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. 2016 Mol Med Rep pmid:27121018
Wang H et al. [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. 2016 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:27117217
Gehring KB et al. Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. 2016 Learn. Mem. pmid:27084927
Li QQ et al. Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. 2016 Int. J. Oncol. pmid:27082124
Duclot F et al. Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). 2016 Horm Behav pmid:27074037
Toki S et al. The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. 2016 Thorax pmid:27071418
Chen J et al. Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα. 2016 PLoS ONE pmid:27058040
Zhang F et al. Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. 2016 Anal. Chem. pmid:27046421
Huynh NC et al. Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells. 2016 J. Cell. Biochem. pmid:27043246
Gupta DK et al. DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. 2016 Sci Rep pmid:27033103
Clarke CJ et al. ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. 2016 J. Lipid Res. pmid:27013100
Zhang HP et al. Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. 2016 Respirology pmid:26991676
Sharma K et al. Constitutive hyperactivity of histone deacetylases enhances radioresistance in Lepidopteran Sf9 insect cells. 2016 Biochim. Biophys. Acta pmid:26968462
Majumdar G and Raghow R Trichostatin A induces a unique set of microRNAs including miR-129-5p that blocks cyclin-dependent kinase 6 expression and proliferation in H9c2 cardiac myocytes. 2016 Mol. Cell. Biochem. pmid:26946427
Sakharkar AJ et al. A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. 2016 Brain Struct Funct pmid:26941165
Cui W et al. A SUMO-acetyl switch in PXR biology. 2016 Biochim. Biophys. Acta pmid:26883953
Ho TT et al. Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. 2016 Int J Biochem Mol Biol pmid:27570640
Ma X et al. Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. 2016 BMC Genomics pmid:26847576
Li L et al. Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. 2016 Tumour Biol. pmid:26831669
Rios EC et al. The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. 2016 Life Sci. pmid:26826317
Deguise MO et al. Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. 2016 Sci Rep pmid:27349908
Wang X et al. The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. 2016 In Vitro Cell. Dev. Biol. Anim. pmid:26822431
Kuan CS et al. Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. 2016 PLoS ONE pmid:26807725
Noh H et al. Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. 2016 Biochem. Biophys. Res. Commun. pmid:26768368
Hosseini SM et al. Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. 2016 BMC Genomics pmid:26725231
Lee K et al. Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis. 2016 J. Plant Physiol. pmid:26724747
Sheng Y et al. Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma. 2016 Gynecol. Oncol. pmid:26597461
Yeh BW et al. Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. 2016 Toxicol. Appl. Pharmacol. pmid:26589485
Asgar MA et al. Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. 2016 Int. J. Oncol. pmid:26575528
Saini M et al. Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. 2016 Reprod. Fertil. Dev. pmid:25409339
Ranganathan P et al. Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. 2016 Kidney Int. pmid:26509586
Selokar NL et al. Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. 2016 Zygote pmid:26503476
Trifunović D et al. HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. 2016 Hum. Mol. Genet. pmid:28172811
Alizadeh E et al. Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells. 2016 Chem Biol Drug Des pmid:26360933
Piao J et al. Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC. 2016 Oncotarget pmid:27507059
Kim HJ et al. Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. 2016 Biotechnol. Lett. pmid:26341652
Kim SH et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. 2016 Endocrine pmid:26219406
Tan CS et al. Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. 2016 Mol. Neurobiol. pmid:26162318