trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
| Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
| Davis FJ et al. | Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15388503 |
| Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
| Usui T et al. | HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22389387 |
| Zhang LX et al. | Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20382965 |
| Yang Q et al. | Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23043075 |
| Guo W et al. | Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19700647 |
| Popova AP et al. | Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20190033 |
| Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
| Kuang PP et al. | Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17209135 |
| Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |
| Alamdari N et al. | Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20538901 |
| Yang H et al. | Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16973938 |
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| Kroening S et al. | Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20032117 |
| Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
| Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
| Noh H et al. | Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19553350 |
| Pang M et al. | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19640900 |
| Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
| Marumo T et al. | Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19906951 |
| Freidkin I et al. | Effects of histone deacetylase inhibitors on rat mesangial cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19923417 |
| Dong G et al. | Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19889954 |
| Gill RK et al. | Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23195070 |
| Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
| Zampetaki A et al. | Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17626239 |
| Hwang DY and Ismail-Beigi F | Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16162661 |
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| Sathe A et al. | MicroRNA let-7f: a novel regulator of innate immune response in human endocervical cells. | 2014 | Am. J. Reprod. Immunol. | pmid:24405266 |
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| Koch A et al. | Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12871851 |
| Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
| Sanders YY et al. | Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20724553 |
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| Meja KK et al. | Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18421014 |
| Kim H et al. | The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816733 |
| Cao D et al. | COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17395887 |
| Kicic A et al. | Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20110557 |
| Bogaard HJ et al. | Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:21297075 |
| Tian F et al. | NMDA receptor activation induces differential epigenetic modification of Bdnf promoters in hippocampal neurons. | 2010 | Amino Acids | pmid:19565326 |
| Marengo E et al. | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. | 2004 | Anal Bioanal Chem | pmid:15257427 |
| Heltweg B and Jung M | A microplate reader-based nonisotopic histone deacetylase activity assay. | 2002 | Anal. Biochem. | pmid:11878795 |
| Wegener D et al. | Improved fluorogenic histone deacetylase assay for high-throughput-screening applications. | 2003 | Anal. Biochem. | pmid:14511685 |
| Marshall S et al. | Enhanced expression of uridine diphosphate-N-acetylglucosaminyl transferase (OGT) in a stable, tetracycline-inducible HeLa cell line using histone deacetylase inhibitors: kinetics of cytosolic OGT accumulation and nuclear translocation. | 2003 | Anal. Biochem. | pmid:12871726 |
| Kim JY et al. | Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. | 2002 | Anal. Chem. | pmid:12433071 |
| Zhang F et al. | Assessment of the effect of trichostatin A on HeLa cells through FT-IR spectroscopy. | 2015 | Anal. Chem. | pmid:25602746 |
| Mackay CL et al. | Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. | 2008 | Anal. Chem. | pmid:18457408 |
| Zhang F et al. | Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. | 2016 | Anal. Chem. | pmid:27046421 |
| Xu T and Hu X | Copper-catalyzed 1,2-addition of α-carbonyl iodides to alkynes. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470461 |