trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alao JP et al. | Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:17018141 |
| Arapshian A et al. | Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. | 2004 | Mol. Cancer | pmid:15113415 |
| Liu TY et al. | EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis. | 2010 | Mol. Cancer | pmid:20144199 |
| Li Y et al. | Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. | 2010 | Mol. Cancer | pmid:20946668 |
| Kongruttanachok N et al. | Replication independent DNA double-strand break retention may prevent genomic instability. | 2010 | Mol. Cancer | pmid:20356374 |
| Mühlethaler-Mottet A et al. | Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. | 2008 | Mol. Cancer | pmid:18549473 |
| Das PM et al. | Methylation mediated silencing of TMS1/ASC gene in prostate cancer. | 2006 | Mol. Cancer | pmid:16848908 |
| Alao JP et al. | The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. | 2006 | Mol. Cancer | pmid:16503970 |
| Alao JP et al. | Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:16504004 |
| Chen WP et al. | Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. | 2010 | Mol. Biol. Rep. | pmid:20237852 |
| Marenzi S et al. | Efficiency of expression of transfected genes depends on the cell cycle. | 1999 | Mol. Biol. Rep. | pmid:10634509 |
| Mittal MK et al. | Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. | 2010 | Mol. Biol. Rep. | pmid:19277896 |
| Yin H et al. | Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. | 2011 | Mol. Biol. Rep. | pmid:21181272 |
| Royo H et al. | Bsr, a nuclear-retained RNA with monoallelic expression. | 2007 | Mol. Biol. Cell | pmid:17507654 |
| Nishiyama A et al. | Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. | 2006 | Mol. Biol. Cell | pmid:16339075 |
| Agostinho M et al. | Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. | 2004 | Mol. Biol. Cell | pmid:14978217 |
| Cabrero JR et al. | Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. | 2006 | Mol. Biol. Cell | pmid:16738306 |
| Valenzuela-Fernández A et al. | Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. | 2005 | Mol. Biol. Cell | pmid:16148047 |
| He Q et al. | Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. | 2012 | Mol. Biol. Cell | pmid:22718902 |
| Cimini D et al. | Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. | 2003 | Mol. Biol. Cell | pmid:12972566 |
| Li X and Bai XZ | [NF-kappaB modulates activation of the BMP-2 gene by trichostatin A]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140318 |
| Kir'ianov GI et al. | [Nucleosome positioning within neomycinphosphotransferase gene (NPTII) on yeast plasmid in repressed and active state]. | 2008 Nov-Dec | Mol. Biol. (Mosk.) | pmid:19140324 |
| Rahimian A et al. | [Inhibition of Histone Deacetylases Reverses Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells through a Slug Mediated Mechanism]. | Mol. Biol. (Mosk.) | pmid:29989579 | |
| Ramakrishnan G et al. | Histone acetyltransferases and deacetylase in Entamoeba histolytica. | 2004 | Mol. Biochem. Parasitol. | pmid:15555732 |
| Isakov E et al. | Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. | 2008 | Mol. Biochem. Parasitol. | pmid:18191469 |
| Dubois F et al. | Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. | 2009 | Mol. Biochem. Parasitol. | pmid:19538992 |
| Bricambert J et al. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. | 2016 | Mol Metab | pmid:27900262 |
| Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |
| Peng L et al. | Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma. | 2013 | Mol Med Rep | pmid:23358566 |
| Meng J et al. | Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. | 2015 | Mol Med Rep | pmid:25695595 |
| Ma J et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. | 2015 | Mol Med Rep | pmid:25634603 |
| Xiong J et al. | USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. | 2014 | Mol Med Rep | pmid:25323692 |
| Han RF et al. | Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. | 2014 | Mol Med Rep | pmid:25269990 |
| Lu HG et al. | TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion. | 2014 | Mol Med Rep | pmid:25175940 |
| Gao L et al. | Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells. | 2018 | Mol Med Rep | pmid:29344672 |
| Zhu XJ et al. | Novel tumor-suppressor gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer. | 2014 | Mol Med Rep | pmid:24718752 |
| Qu H et al. | Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. | 2016 | Mol Med Rep | pmid:27431944 |
| Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
| Du R et al. | Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. | 2016 | Mol Med Rep | pmid:27121018 |
| Zhang L et al. | Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors. | 2013 | Mol Med Rep | pmid:23504001 |
| Tao LL et al. | TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells. | 2017 | Mol Med Rep | pmid:28849174 |
| Zhang Q et al. | Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins. | 2016 | Mol Med Rep | pmid:26647731 |
| Robers MB et al. | Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. | 2011 | Mol Biosyst | pmid:20931131 |
| Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |
| Hizaki K et al. | Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. | 2011 | Mod. Pathol. | pmid:21317879 |
| Higashiyama R et al. | Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. | 2010 | Mod Rheumatol | pmid:19784544 |
| van West P et al. | Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. | 2008 | Microbiology (Reading, Engl.) | pmid:18451057 |
| Nakaya Y et al. | Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B. | 2011 | Microbes Infect. | pmid:20951222 |
| Liu C and Xu D | Inhibition of histone deacetylases. | 2004 | Methods Mol. Biol. | pmid:15273406 |
| Garfinkel MD et al. | Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila. | 2004 | Methods Mol. Biol. | pmid:15273410 |