trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Fibrosis D005355 23 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Stroke D020521 32 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Translocation, Genetic D014178 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Radiation Injuries D011832 14 associated lipids
Leishmaniasis D007896 19 associated lipids
Enteritis D004751 8 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Osteomalacia D010018 5 associated lipids
Glioblastoma D005909 27 associated lipids
Keloid D007627 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Medulloblastoma D008527 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Cat Diseases D002371 12 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Retinoblastoma D012175 12 associated lipids
Genomic Instability D042822 7 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Mastocytoma D034801 3 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Srirattana K et al. Full-term development of gaur-bovine interspecies somatic cell nuclear transfer embryos: effect of trichostatin A treatment. 2012 Cell Reprogram pmid:22578161
Truong M et al. Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence. 2012 Br. J. Cancer pmid:22596233
Hsu DW et al. Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. 2012 Nucleic Acids Res. pmid:22600736
Viñuelas J et al. Towards experimental manipulation of stochasticity in gene expression. 2012 Prog. Biophys. Mol. Biol. pmid:22609563
Kang FW et al. Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. 2012 Oncol. Rep. pmid:22552321
Meng J et al. The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. 2012 Oncol. Rep. pmid:22552631
Hsieh TH et al. Phthalates stimulate the epithelial to mesenchymal transition through an HDAC6-dependent mechanism in human breast epithelial stem cells. 2012 Toxicol. Sci. pmid:22552774
Chawalit S et al. Trichostatin A and ascorbic acid assist in the development of porcine handmade cloned embryos via different physiologic pathways. 2012 Reprod Sci pmid:22534331
Wang W et al. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. 2012 Nucleic Acids Res. pmid:21967847
Lee TB et al. Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline. 2012 Cell Biol. Toxicol. pmid:21968610
Rhodes LV et al. The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. 2012 Oncol. Rep. pmid:21971930
Liu W et al. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. 2012 PLoS ONE pmid:23152903
Balsas P et al. Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. 2012 Leuk. Res. pmid:21978467
Deckmann K et al. Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. 2012 Cell. Signal. pmid:21983014
Hoque MA et al. Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. 2012 Bioorg. Med. Chem. Lett. pmid:23021104
Zhang L et al. Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts. 2012 J. Biol. Chem. pmid:23024362
Merschbaecher K et al. Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. 2012 PLoS ONE pmid:23028801
Zhao ZN et al. TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. 2012 PLoS ONE pmid:23028803
Banik D et al. Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. 2012 PLoS ONE pmid:23028998
Lopez-Atalaya JP et al. Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome. 2012 J. Med. Genet. pmid:21984751
Bergman JA et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. 2012 J. Med. Chem. pmid:23009203
Li Y et al. Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. 2012 Cancer Lett. pmid:22266186
Vaidya AS et al. Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. 2012 Bioorg. Med. Chem. Lett. pmid:23010266
Bajbouj K et al. P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. 2012 J. Neurooncol. pmid:22270849
Park KS et al. Histone modification-mediated Lhx2 gene expression. 2012 Biochem. Biophys. Res. Commun. pmid:23036195
Zhang L et al. Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. 2012 J. Pharmacol. Exp. Ther. pmid:22271820
He D et al. Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. 2012 Eur. J. Cancer Prev. pmid:22273848
Hosoya T et al. Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. 2012 J. Nat. Prod. pmid:22276693
Kan R et al. Potential role for PADI-mediated histone citrullination in preimplantation development. 2012 BMC Dev. Biol. pmid:22712504
Wang HF et al. Transcription levels of sirtuin family in neural stem cells and brain tissues of adult mice. 2012 Cell. Mol. Biol. (Noisy-le-grand) pmid:22992439
Ma J et al. Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. 2012 Int. J. Mol. Med. pmid:22992863
Shi YL et al. Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. 2012 J. Dermatol. Sci. pmid:22999682
Tomosugi M et al. Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. 2012 Cancer Sci. pmid:22957647
Miyagawa K et al. Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. 2012 Behav. Brain Res. pmid:22963996
Liu N et al. Histone deacetylase inhibitors inducing human cervical cancer cell apoptosis by decreasing DNA-methyltransferase 3B. 2012 Chin. Med. J. pmid:22964322
Brown RE et al. Superinduction of leptin mRNA in mouse hypothalamic neurons. 2012 Neuroreport pmid:22964970
Mateen S et al. Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells. 2012 Epigenetics pmid:22965008
To SQ et al. Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer. 2012 J. Steroid Biochem. Mol. Biol. pmid:22929011
Liao V et al. Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects. 2012 Bioorg. Med. Chem. Lett. pmid:22932316
Shan J et al. ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. 2012 J. Biol. Chem. pmid:22955275
Sadoul K et al. HDAC6 controls the kinetics of platelet activation. 2012 Blood pmid:22955928
Conway GD et al. Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation. 2012 Glia pmid:22927334
de Souza CF et al. Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. 2012 PLoS ONE pmid:22984562
Zhai FX et al. RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines. 2012 J. Cancer Res. Clin. Oncol. pmid:22179198
Cheng SP et al. Regulation of leptin receptor expression in human papillary thyroid cancer cells. 2012 Biomed. Pharmacother. pmid:22560341
Sancho-Pelluz J and Paquet-Durand F HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. 2012 Adv. Exp. Med. Biol. pmid:22183322
Chen H et al. LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. 2012 Cancer Lett. pmid:22743615
Vadnal J et al. Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. 2012 Exp Brain Res pmid:22811216
Lin KT et al. HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. 2012 Clin. Cancer Res. pmid:22811583
He Q et al. Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. 2012 Mol. Biol. Cell pmid:22718902
Balmer NV et al. Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. 2012 Hum. Mol. Genet. pmid:22723015
Oh HJ et al. Trichostatin a improves preimplantation development of bovine cloned embryos and alters expression of epigenetic and pluripotency genes in cloned blastocysts. 2012 J. Vet. Med. Sci. pmid:22785124
Sung TY et al. Innovative in vitro chemo-hormonal drug therapy for refractory thyroid carcinomas. 2012 J. Korean Med. Sci. pmid:22787366
Agudelo M et al. Alcohol-induced serotonergic modulation: the role of histone deacetylases. 2012 Alcohol pmid:22796363
Tong K et al. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. 2012 Eukaryotic Cell pmid:22771823
Zheng L et al. [Detecting acetylated proteins by affinity chromatography column]. 2012 Zhonghua Xue Ye Xue Za Zhi pmid:22781610
Yao J et al. ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism. 2012 Life Sci. pmid:22781708
Kadowaki M et al. DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. 2012 Int. J. Cancer pmid:21437897
Sangalli JR et al. Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle. 2012 Cell Reprogram pmid:22468998
Zhang S et al. [Effect of trichostatin A and paclitaxel on the growth and apoptosis of lung adenocarcinoma cell lines]. 2012 Zhonghua Zhong Liu Za Zhi pmid:22967465
Yamamura N and Kishimoto T Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma. 2012 Exp. Mol. Pathol. pmid:22472323
Zhang HN et al. Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. 2012 J. Cardiovasc. Pharmacol. pmid:22472906
Qin ZX et al. [Effect of TSA and VPA treatment on long-tailed macaque (Macaca fascicularis)-pig interspecies somatic cell nuclear transfer]. 2012 Yi Chuan pmid:22425953
Zhou X et al. Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. 2012 Biochem. Biophys. Res. Commun. pmid:22425986
Fleiss B et al. Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. 2012 J Neuroinflammation pmid:22512781
Eun CH et al. Activation and epigenetic regulation of DNA transposon nDart1 in rice. 2012 Plant Cell Physiol. pmid:22514089
Ching LY et al. Synergistic effect of p53 on TSA-induced stanniocalcin 1 expression in human nasopharyngeal carcinoma cells, CNE2. 2012 J. Mol. Endocrinol. pmid:22493143
Gou Z et al. Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens. 2012 PLoS ONE pmid:22438967
Yoshida A et al. Aberrant spikelet and panicle1, encoding a TOPLESS-related transcriptional co-repressor, is involved in the regulation of meristem fate in rice. 2012 Plant J. pmid:22136599
Bar-Nur O et al. Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives. 2012 J Mol Cell Biol pmid:22430918
Hu XL et al. [Effects of trichostatin A on the expressions of inflammatory cytokines and toll-like receptor 4 and the acetylation of nuclear factor-κB induced by lipopolysaccharide in macrophage]. 2012 Sheng Li Xue Bao pmid:23258328
Shen T et al. Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. 2012 Int. J. Biochem. Cell Biol. pmid:22138223
Rossi LE et al. Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. 2012 J. Leukoc. Biol. pmid:22124136
Jung N et al. Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma. 2012 J. Korean Med. Sci. pmid:22690089
Landreville S et al. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. 2012 Clin. Cancer Res. pmid:22038994
Nunes MJ et al. Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway. 2012 J. Lipid Res. pmid:22693257
Ikehata M et al. Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines. 2012 Biol. Pharm. Bull. pmid:22382314
Andrews KT et al. Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. 2012 PLoS ONE pmid:22384084
Zhu S et al. TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells. 2012 J. Cell. Biochem. pmid:22388778
Usui T et al. HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. 2012 Am. J. Physiol. Heart Circ. Physiol. pmid:22389387
Wang H et al. Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. 2012 J Neural Transm pmid:22407380
Yang PM et al. CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. 2012 Epigenetics pmid:22419072
Colussi C et al. P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22859492
Serrat N et al. Deacetylation of C/EBPβ is required for IL-4-induced arginase-1 expression in murine macrophages. 2012 Eur. J. Immunol. pmid:22865229
Kraus J Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes. 2012 Ann. N. Y. Acad. Sci. pmid:22823387
Qiao F et al. Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells. 2012 Oncol. Rep. pmid:22825043
Shao G et al. [Effect of monoamine oxidase inhibitor on the differentiation of malignant glioma cell]. 2012 Sheng Wu Yi Xue Gong Cheng Xue Za Zhi pmid:22826952
Fan LX et al. Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. 2012 Kidney Int. pmid:21900881
Yu J et al. Regulation of radiosensitivity by HDAC inhibitor trichostatin A in the human cervical carcinoma cell line Hela. 2012 Eur. J. Gynaecol. Oncol. pmid:22873101
Zhu L et al. Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. 2012 Pediatr. Pulmonol. pmid:21905265
Karolczak-Bayatti M et al. Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. 2012 Reprod Sci pmid:22875848
Pufahl L et al. Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. 2012 J. Cell. Mol. Med. pmid:21883892
Li L et al. Regulation of histone acetylation by NDRG2 in glioma cells. 2012 J. Neurooncol. pmid:21912936
Li L et al. Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. 2012 Am. J. Physiol. Renal Physiol. pmid:21937606
Sustáčková G et al. Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. 2012 J. Cell. Physiol. pmid:21732356
Dehnugara T et al. An in vitro, short-term culture method for mammalian haploid round spermatids amenable for molecular manipulation. 2012 Mol. Reprod. Dev. pmid:21953649
Wang C et al. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. 2012 Diabetes Metab. Res. Rev. pmid:22228707
Gupta K et al. Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. 2012 PLoS ONE pmid:23285096
McCullough SD et al. Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:23236151
Xie BT et al. [Telomere lengthening by trichostatin A treatment in cloned pigs]. 2012 Yi Chuan pmid:23262106