trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lim SY et al. | Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. | 2016 | Methods Mol. Biol. | pmid:25520285 |
| Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
| Kim HR et al. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. | 2016 | PLoS ONE | pmid:27855185 |
| Tombolan L et al. | Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. | 2016 | BMC Cancer | pmid:27842508 |
| Tao W et al. | Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. | 2016 | Neuroscience | pmid:27646288 |
| Chen W et al. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. | 2016 | Biochim. Biophys. Acta | pmid:27638301 |
| Bauer I et al. | A Class 1 Histone Deacetylase with Potential as an Antifungal Target. | 2016 | MBio | pmid:27803184 |
| Igaz N et al. | Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. | 2016 | Colloids Surf B Biointerfaces | pmid:27434153 |
| Qu H et al. | Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. | 2016 | Mol Med Rep | pmid:27431944 |
| Choi SY et al. | Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. | 2016 | J. Cell. Mol. Med. | pmid:27420561 |
| Dhoke NR et al. | Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. | 2016 | Stem Cell Res | pmid:27394013 |
| Drzewiecka H et al. | Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27393180 |
| Li L et al. | Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. | 2016 | Tumour Biol. | pmid:26831669 |
| Rios EC et al. | The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. | 2016 | Life Sci. | pmid:26826317 |
| Wang X et al. | The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. | 2016 | In Vitro Cell. Dev. Biol. Anim. | pmid:26822431 |
| Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |
| Kim HJ et al. | Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. | 2016 | Biotechnol. Lett. | pmid:26341652 |
| Nayak S et al. | Superior Versus Inferior Vestibular Neuritis: Are There Intrinsic Differences in Infection, Reactivation, or Production of Infectious Particles Between the Vestibular Ganglia? | 2015 | Otol. Neurotol. | pmid:25978655 |
| Chen MH et al. | A new trichostatin analog from Streptomyces sp. CPCC 203909. | 2015 | J Asian Nat Prod Res | pmid:25977996 |
| Inoue K et al. | Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. | 2015 | Sci Rep | pmid:25974394 |
| El-Awady RA et al. | Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. | 2015 | Cancer Biol. Ther. | pmid:25962089 |
| Huan Y et al. | Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. | 2015 | PLoS ONE | pmid:25962071 |
| Koumbadinga GA et al. | Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. | 2015 | Biochim. Biophys. Acta | pmid:25959059 |
| Meschini R et al. | Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. | 2015 | Mutat. Res. | pmid:25942615 |
| Ooi JY et al. | HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. | 2015 | Epigenetics | pmid:25941940 |
| Marquardt JU et al. | Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. | 2015 | J. Hepatol. | pmid:25937435 |
| Han Y et al. | Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. | 2015 | Exp. Cell Res. | pmid:25933513 |
| Mishra DR et al. | Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. | 2015 | PLoS ONE | pmid:25923237 |
| Zhao W et al. | A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. | 2015 | J Chin Med Assoc | pmid:25913212 |
| Lin S et al. | IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. | 2015 | Cell. Physiol. Biochem. | pmid:25896783 |
| Iancu-Rubin C and Hoffman R | Role of epigenetic reprogramming in hematopoietic stem cell function. | 2015 | Curr. Opin. Hematol. | pmid:26049747 |
| Huisman C et al. | Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. | 2015 | Epigenetics | pmid:25830725 |
| Fujii K et al. | Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. | 2015 | J. Cell. Physiol. | pmid:25820447 |
| Pandey SC et al. | Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. | 2015 | Neurobiol. Dis. | pmid:25814047 |
| Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
| Asaoka N et al. | Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. | 2015 | Neurosci. Lett. | pmid:25796177 |
| Martini M et al. | Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. | 2015 | Mediators Inflamm. | pmid:26491230 |
| Butler PL et al. | Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. | 2015 | J. Biol. Chem. | pmid:25787079 |
| Zelko IN and Folz RJ | Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25749103 |
| Cao K et al. | Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. | 2015 | Oncogene | pmid:25745993 |
| Mostafavi-Pour Z et al. | Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. | 2015 | Pathol. Oncol. Res. | pmid:25743258 |
| Hsu HH et al. | Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A. | 2015 | Int. Immunopharmacol. | pmid:25698558 |
| Meng J et al. | Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. | 2015 | Mol Med Rep | pmid:25695595 |
| Wang P et al. | Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. | 2015 | Plant Cell Physiol. | pmid:25670712 |
| Mizutani E et al. | Generation of cloned mice from adult neurons by direct nuclear transfer. | 2015 | Biol. Reprod. | pmid:25653280 |
| Ma J et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. | 2015 | Mol Med Rep | pmid:25634603 |
| Shah S et al. | Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms. | 2015 | Biomed Res Int | pmid:25629043 |
| Hartman H et al. | Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. | 2015 | Dig. Dis. Sci. | pmid:25492506 |
| Jiang H et al. | Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. | 2015 | Acta Histochem. | pmid:25480399 |
| Du J et al. | HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. | 2015 | J. Cell. Physiol. | pmid:25475100 |
| Xu T and Hu X | Copper-catalyzed 1,2-addition of α-carbonyl iodides to alkynes. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470461 |
| Rabineau M et al. | Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. | 2015 | Biomaterials | pmid:25453945 |
| Wang J et al. | Fungal metabolite myriocin promotes human herpes simplex virus-2 infection. | 2015 | Life Sci. | pmid:25447452 |
| Wang X et al. | Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25434997 |
| Ma X et al. | Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. | 2015 | Oncol. Rep. | pmid:25420545 |
| Cui Y et al. | Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. | 2015 | PLoS ONE | pmid:26710276 |
| Sharma S et al. | Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. | 2015 | J. Mol. Neurosci. | pmid:25391764 |
| Hao ZF et al. | Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells. | 2015 | Tumour Biol. | pmid:25371069 |
| Saraf S et al. | Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers. | 2015 | Transfusion | pmid:25363624 |
| Fukui T et al. | Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. | 2015 | Toxicology | pmid:25758465 |
| Wang Y et al. | Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. | 2015 | Chem. Biol. | pmid:25699604 |
| Chahine MN et al. | Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. | 2015 | Cardiovasc. Res. | pmid:25341891 |
| Ji M et al. | HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. | 2015 | Oncol. Rep. | pmid:25813246 |
| Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
| Wang Y et al. | Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats. | 2015 | J. Mol. Neurosci. | pmid:24829091 |
| Yamanegi K et al. | Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. | 2015 | Int. J. Oncol. | pmid:25778932 |
| Ma XH et al. | Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. | 2015 | Int. J. Neurosci. | pmid:24730998 |
| Li Z et al. | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. | 2015 | Gastric Cancer | pmid:24481854 |
| Cao QF et al. | TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. | 2015 | Cancer Biother. Radiopharm. | pmid:25760728 |
| Mackmull MT et al. | Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). | 2015 | Mol. Cell Proteomics | pmid:25755299 |
| Rodrigues MF et al. | Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. | 2015 | J. Cell. Biochem. | pmid:25510910 |
| Uchida H et al. | Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. | 2015 | J. Pharmacol. Sci. | pmid:26318673 |
| Passeri E et al. | Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. | 2015 | Neurosci. Res. | pmid:26260244 |
| Cavalieri V and Spinelli G | Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. | 2015 | PLoS ONE | pmid:26618749 |
| Zhang Y et al. | The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. | 2015 | PLoS ONE | pmid:26606052 |
| Nakada Y et al. | Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells. | 2015 | Endocr. J. | pmid:26497760 |
| Uchida H and Ito S | Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2'-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells. | 2015 | Neuroreport | pmid:26485095 |
| Barr MP et al. | VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. | 2015 | Epigenomics | pmid:26479311 |
| Kotze AC et al. | Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. | 2015 | Int J Parasitol Drugs Drug Resist | pmid:27120067 |
| Zhang P et al. | Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. | 2015 | PLoS ONE | pmid:26287365 |
| Perez-Janices N et al. | Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. | 2015 | Oncotarget | pmid:26284587 |
| Keil KP et al. | Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. | 2015 | Dev. Dyn. | pmid:26283270 |
| Hsing CH et al. | Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. | 2015 | Mediators Inflamm. | pmid:26273133 |
| Zhou L et al. | Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. | 2015 | J. Virol. | pmid:26269170 |
| Zheng J et al. | Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). | 2015 | Eur. J. Immunol. | pmid:26255980 |
| Mehta A et al. | HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. | 2015 | Mol. Cell. Endocrinol. | pmid:26213324 |
| Sancak D and Ozden S | Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. | 2015 | Toxicol In Vitro | pmid:26208285 |
| Cabanel M et al. | Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. | 2015 | PLoS ONE | pmid:26196676 |
| Suo H et al. | NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. | 2015 | Neuropharmacology | pmid:26188143 |
| Gutiérrez J et al. | Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. | 2015 | Mol. Cell. Biochem. | pmid:26173416 |
| Hedberg Oldfors C et al. | Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. | 2015 | BMC Genet. | pmid:26170120 |
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| Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
| Huan Y et al. | Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. | 2015 | Cell Reprogram | pmid:26053519 |
| Kaldre D et al. | Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. | 2015 | Bioorg. Med. Chem. | pmid:26048026 |
| Liu Y and Li S | A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. | 2015 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:26022499 |
| Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |
| Koppaka V et al. | Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. | 2015 | Mol. Vis. | pmid:25999677 |
| Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |
| Chen Z et al. | Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. | 2015 | Anticancer Agents Med Chem | pmid:25991546 |