trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chiou SK and Hoa N | Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. | 2009 | Apoptosis | pmid:19757064 |
| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
| Zhang CZ et al. | Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. | 2011 | Apoptosis | pmid:21468663 |
| Facchetti F et al. | Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. | 2004 | Apoptosis | pmid:15314285 |
| Roh MS et al. | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | 2004 | Apoptosis | pmid:15314286 |
| Chen T et al. | Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. | 2002 | Arch. Biochem. Biophys. | pmid:12464268 |
| Bort R et al. | Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. | 2004 | Arch. Biochem. Biophys. | pmid:15130783 |
| Adachi T et al. | Histone deacetylase inhibitors stimulate the susceptibility of A549Â cells to a plasma-activated medium treatment. | 2016 | Arch. Biochem. Biophys. | pmid:27470189 |
| Katula KS et al. | Cell cycle specific changes in the human cyclin B1 gene regulatory region as revealed by response to trichostatin A. | 2002 | Arch. Biochem. Biophys. | pmid:12054478 |
| Garrison PM et al. | Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. | 2000 | Arch. Biochem. Biophys. | pmid:10666294 |
| Wood M et al. | Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6. | 2018 | Arch. Biochem. Biophys. | pmid:29233643 |
| Sichtig N et al. | Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. | 2007 | Arch. Biochem. Biophys. | pmid:17897615 |
| Senawong T et al. | BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. | 2005 | Arch. Biochem. Biophys. | pmid:15639232 |
| Diao JS et al. | Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. | 2011 | Arch. Dermatol. Res. | pmid:21400246 |
| Zhu K et al. | Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. | 2008 | Arch. Gynecol. Obstet. | pmid:17680259 |
| Hizume K et al. | Nano-scale analyses of the chromatin decompaction induced by histone acetylation. | 2010 | Arch. Histol. Cytol. | pmid:22572182 |
| Royce SG et al. | Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice. | 2012 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:22684086 |
| Piotrowska H and Jagodzinski PP | Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. | 2009 | Arch. Med. Res. | pmid:19427965 |
| Hou SY et al. | Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. | 2014 | Arch. Med. Res. | pmid:24316396 |
| Yu L et al. | Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. | 2012 | Arch. Med. Res. | pmid:22564421 |
| Cunneen TS et al. | In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells. | 2009 | Arch. Ophthalmol. | pmid:19365017 |
| Schmidt K et al. | Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. | 1999 | Arch. Pharm. (Weinheim) | pmid:10575368 |
| Ahn MR et al. | Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. | 2004 | Arch. Pharm. Res. | pmid:15180307 |
| Han SB and Lee JK | Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. | 2009 | Arch. Pharm. Res. | pmid:19407980 |
| Kim SN et al. | Regulation of adipocyte differentiation by histone deacetylase inhibitors. | 2009 | Arch. Pharm. Res. | pmid:19407971 |
| Joung KE et al. | Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15283467 |
| Min KN et al. | Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15202563 |
| Shinde V et al. | Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox and STOP-Tox tests. | 2017 | Arch. Toxicol. | pmid:27188386 |
| Pallocca G et al. | Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. | 2016 | Arch. Toxicol. | pmid:26705709 |
| Rempel E et al. | A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. | 2015 | Arch. Toxicol. | pmid:26272509 |
| Balmer NV et al. | From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. | 2014 | Arch. Toxicol. | pmid:24935251 |
| Zapletal O et al. | Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. | 2017 | Arch. Toxicol. | pmid:27830268 |
| Cipriano M et al. | The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells. | 2017 | Arch. Toxicol. | pmid:27909741 |
| Lu MC et al. | Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. | 2009 | Arch. Toxicol. | pmid:18709356 |
| Nordén R et al. | Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression. | 2010 | Arch. Virol. | pmid:20039087 |
| Dje N'Guessan P et al. | Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19122173 |
| Choi JH et al. | Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141407 |
| Inoue K et al. | Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:17008592 |
| Colussi C et al. | P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22859492 |
| Cai D et al. | Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. | 2015 | Arthritis Res. Ther. | pmid:26408027 |
| Misaki K et al. | Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. | 2011 | Arthritis Res. Ther. | pmid:21592365 |
| Gillespie J et al. | Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. | 2012 | Arthritis Rheum. | pmid:21952924 |
| Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
| Culley KL et al. | Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. | 2013 | Arthritis Rheum. | pmid:23575963 |
| Wang Y et al. | Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. | 2006 | Arthritis Rheum. | pmid:16802366 |
| Huber LC et al. | Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. | 2007 | Arthritis Rheum. | pmid:17665426 |
| Hemmatazad H et al. | Histone deacetylase 7, a potential target for the antifibrotic treatment of systemic sclerosis. | 2009 | Arthritis Rheum. | pmid:19404935 |
| Sanaei M et al. | Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 Cells | 2017 | Asian Pac. J. Cancer Prev. | pmid:29286617 |
| Yang XL et al. | Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969901 |
| Cheng DD et al. | Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799338 |