trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Fibrosis D005355 23 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Stroke D020521 32 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Translocation, Genetic D014178 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Radiation Injuries D011832 14 associated lipids
Leishmaniasis D007896 19 associated lipids
Enteritis D004751 8 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Chondrosarcoma D002813 9 associated lipids
Osteomalacia D010018 5 associated lipids
Glioblastoma D005909 27 associated lipids
Keloid D007627 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Medulloblastoma D008527 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Cat Diseases D002371 12 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Polycystic Kidney, Autosomal Dominant D016891 6 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Retinoblastoma D012175 12 associated lipids
Genomic Instability D042822 7 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Mastocytoma D034801 3 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Ji Z et al. Integrating genomics and proteomics data to predict drug effects using binary linear programming. 2014 PLoS ONE pmid:25036040
Lv W et al. Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. 2014 PLoS ONE pmid:25412078
Lu HK et al. Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. 2014 PLoS ONE pmid:25409334
Yang W et al. Effect of trichostatin A on gelsolin levels, proteolysis of amyloid precursor protein, and amyloid beta-protein load in the brain of transgenic mouse model of Alzheimer's disease. 2014 Curr Alzheimer Res pmid:25387339
Ying H et al. Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling. 2014 Int J Mol Sci pmid:25380525
Nishida N et al. Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. 2014 Dig Dis pmid:25376292
Xie M et al. Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. 2014 Mol. Vis. pmid:25352747
Xiong J et al. USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. 2014 Mol Med Rep pmid:25323692
Li G et al. Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. 2014 J. Nutr. pmid:25320182
Quan H et al. Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. 2014 Oncogene pmid:23770846
Tomioka T et al. The histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 gene. 2014 Neurosci. Res. pmid:25128386
Zhang Q et al. Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. 2014 Cancer Lett. pmid:25109451
Helm D et al. Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics. 2014 Mol. Cell Proteomics pmid:25106551
Yoshida T et al. Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. 2014 J. Biol. Chem. pmid:25100730
Dubois-Pot-Schneider H et al. Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. 2014 Hepatology pmid:25098666
Wu TH et al. Melatonin prevents neonatal dexamethasone induced programmed hypertension: histone deacetylase inhibition. 2014 J. Steroid Biochem. Mol. Biol. pmid:25090636
Shi Q et al. [Inhibitory effect of trichostatin A on HepG2 cell proliferation and the mechanisms]. 2014 Nan Fang Yi Ke Da Xue Xue Bao pmid:25057056
Tsuji M et al. Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. 2014 J. Pharmacol. Sci. pmid:25048113
Huan YJ et al. Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos. 2014 J. Reprod. Dev. pmid:25047549
Sun G et al. Insights into the lysine acetylproteome of human sperm. 2014 J Proteomics pmid:25038526
Ishihara K Eosinophil cell lines. 2014 Methods Mol. Biol. pmid:24986606
Liu H et al. The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. 2014 PLoS ONE pmid:24984019
Maldonado L et al. An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. 2014 Oncotarget pmid:24980822
Wilson-Edell KA et al. RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. 2014 Oncotarget pmid:24970821
Choi DC et al. MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA. 2014 J. Neurosci. pmid:25232110
Yang XL et al. Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. 2014 Asian Pac. J. Cancer Prev. pmid:24969901
Vorrink SU et al. Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126). 2014 Int J Mol Sci pmid:25116688
Hu Z and Wang J Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. 2014 Cell Reprogram pmid:24945595
Scholpa NE et al. Epigenetic changes in p21 expression in renal cells after exposure to bromate. 2014 Toxicol. Sci. pmid:25015661
Ma H et al. HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. 2014 Int J Mol Sci pmid:24941254
Bartling TR et al. Redox-sensitive gene-regulatory events controlling aberrant matrix metalloproteinase-1 expression. 2014 Free Radic. Biol. Med. pmid:24973648
Busbee PB et al. Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression. 2014 Toxicol. Appl. Pharmacol. pmid:24200994
Poljak M et al. Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. 2014 Reprod Sci pmid:24429678
Shin HJ et al. Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. 2014 J. Virol. pmid:24227836
Unland R et al. Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system. 2014 J. Neurooncol. pmid:24264533
Sun DF et al. Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. 2014 Cell Biol. Int. pmid:24030871
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Skoge RH et al. Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. 2014 DNA Repair (Amst.) pmid:24814981
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Motevalli A et al. The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines. 2014 Breast Cancer Res. Treat. pmid:24807106
Guo W et al. Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma. 2014 Cancer pmid:24798237
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Palii CG et al. Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. 2014 Cell Stem Cell pmid:24792117
Soler E and Grosveld F Targeting epigenetics to speed up repair. 2014 Cell Stem Cell pmid:24792110
Poplutz MK et al. Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation. 2014 Immunobiology pmid:24746556
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Mathiyalagan P et al. The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. 2014 Nucleic Acids Res. pmid:24137001
Hassan MK et al. Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. 2014 PLoS ONE pmid:24728004
Drela K et al. Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. 2014 Cytotherapy pmid:24726658
Zhu XJ et al. Novel tumor-suppressor gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer. 2014 Mol Med Rep pmid:24718752
Tu CY et al. Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. 2014 Biomed Res Int pmid:24707474
Zhang YW et al. Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. 2014 Epigenetics pmid:24699858
Boyer JG et al. Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. 2014 Hum. Mol. Genet. pmid:24691550
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Song BS et al. Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. 2014 Reprod. Fertil. Dev. pmid:23506644
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Xie L et al. Histone deacetylase inhibitors trichostatin A and vorinostat inhibit TGFβ2-induced lens epithelial-to-mesenchymal cell transition. 2014 Invest. Ophthalmol. Vis. Sci. pmid:24994865
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Uhlenbrock F et al. The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. 2014 J. Immunol. pmid:25024379
Li H et al. The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte. 2014 Plant Cell pmid:24464291
Xiao W et al. Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. 2014 J. Cell. Mol. Med. pmid:24456602
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Smith S et al. Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. 2014 PLoS ONE pmid:24466340
Chen HY et al. Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. 2014 Pharmazie pmid:24601225
Kilinc V et al. Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism? 2014 Tumour Biol. pmid:24622883
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Karki P et al. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. 2014 Mol. Cell. Biol. pmid:24469401
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Hou SY et al. Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. 2014 Arch. Med. Res. pmid:24316396
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Chu Y et al. Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. 2014 Cell. Mol. Life Sci. pmid:24531693
Herr MJ et al. Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. 2014 Biochem. Biophys. Res. Commun. pmid:24747564
Reeves ME et al. Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. 2014 PLoS ONE pmid:25007054
Kanski R et al. Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network. 2014 J. Cell. Sci. pmid:25128567
Hennig D et al. Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors. 2014 Macromol Biosci pmid:23966296
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Holownia A et al. Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1. 2014 Naunyn Schmiedebergs Arch. Pharmacol. pmid:24287576
Green BB and Kerr DE Epigenetic contribution to individual variation in response to lipopolysaccharide in bovine dermal fibroblasts. 2014 Vet. Immunol. Immunopathol. pmid:24268632
Jiao F et al. Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. 2013 Stem Cells Dev. pmid:23750509
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