Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wilson DW et al. | Defining the timing of action of antimalarial drugs against Plasmodium falciparum. | 2013 | Antimicrob. Agents Chemother. | pmid:23318799 |
Wolf G et al. | Epigenetic marking and repression of porcine endogenous retroviruses. | 2013 | J. Gen. Virol. | pmid:23324470 |
Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
Bhargavan B et al. | Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. | 2013 | Epigenetics | pmid:23386123 |
Soriano FX et al. | SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites. | 2013 | J. Neurochem. | pmid:23083128 |
Tran L et al. | Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. | 2013 | Psychoneuroendocrinology | pmid:23084728 |
Su SF et al. | miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. | 2013 | Oncogene | pmid:23085757 |
Ziesché E et al. | The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. | 2013 | Nucleic Acids Res. | pmid:23087373 |
Eriksson I et al. | The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. | 2013 | Exp. Cell Res. | pmid:23063877 |
Duncan HF et al. | Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. | 2013 | Exp. Cell Res. | pmid:23562654 |
Wang Y et al. | Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells. | 2013 | J. Cell. Biochem. | pmid:23564418 |
Höring E et al. | The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells. | 2013 | Anticancer Res. | pmid:23564772 |
Chen CH et al. | Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. | 2013 | Theriogenology | pmid:23566670 |
Sato A et al. | Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. | 2013 | J. Cell. Biochem. | pmid:23519646 |
Wang Y et al. | Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. | 2013 | J. Biol. Chem. | pmid:23525112 |
Gao SM et al. | Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. | 2013 | Exp. Hematol. | pmid:23111066 |
Liu RF et al. | Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. | 2013 | Cancer Lett. | pmid:23142219 |
Jang SM et al. | Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23916609 |
Luo C et al. | Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. | 2013 | Theriogenology | pmid:24007823 |
Lauffer BE et al. | Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. | 2013 | J. Biol. Chem. | pmid:23897821 |
Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
Seo J et al. | Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. | 2013 | FEBS J. | pmid:24200051 |
Ononye SN et al. | Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. | 2013 | ACS Med Chem Lett | pmid:24900743 |
Feng L et al. | Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. | 2013 | J. Mol. Med. | pmid:22763818 |
Kadiyala V et al. | Class I lysine deacetylases facilitate glucocorticoid-induced transcription. | 2013 | J. Biol. Chem. | pmid:23946490 |
Itoh M et al. | Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. | 2013 | J. Mol. Neurosci. | pmid:22711563 |
Ning SF et al. | Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2013 | Zygote | pmid:22355002 |
Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
Chachadi VB et al. | Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a. | 2013 | PLoS ONE | pmid:23451223 |
Kim YJ et al. | HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade. | 2013 | Oncogene | pmid:23435418 |
Yeo M et al. | Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23440186 |
Matsushita Y et al. | HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. | 2013 | Br. J. Pharmacol. | pmid:24032674 |
Zhang L et al. | Effect of histone deacetylase inhibitors on cell apoptosis and expression of the tumor suppressor genes RUNX3 and ARHI in ovarian tumors. | 2013 | Mol Med Rep | pmid:23504001 |
Singh RK et al. | Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. | 2013 | Biochemistry | pmid:24079912 |
Tran HT et al. | Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A. | 2013 | J. Korean Med. Sci. | pmid:23400519 |
Day JA and Cohen SM | Investigating the selectivity of metalloenzyme inhibitors. | 2013 | J. Med. Chem. | pmid:24074025 |
Cho JS et al. | Effects of histone deacetylase inhibitor on extracellular matrix production in human nasal polyp organ cultures. | 2013 | Am J Rhinol Allergy | pmid:23406592 |
Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
Biernacka KM et al. | Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. | 2013 | Endocr. Relat. Cancer | pmid:23959956 |
Zhang Z et al. | Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells. | 2013 | Cell Death Dis | pmid:23681228 |
Kannan V et al. | Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. | 2013 | J. Neurosci. Res. | pmid:23686642 |
Oleksiewicz U et al. | Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. | 2013 | Hum. Mol. Genet. | pmid:23591990 |
Breuzard G et al. | Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells. | 2013 | J. Cell. Sci. | pmid:23659998 |
Matteucci E et al. | Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism. | 2013 | Exp. Cell Res. | pmid:23660387 |
Ignatius MS et al. | Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. | 2013 | PLoS ONE | pmid:23667588 |
Webster SJ et al. | Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. | 2013 | J. Biol. Chem. | pmid:23297421 |
Johnson D and Walmsley R | Histone-deacetylase inhibitors produce positive results in the GADD45a-GFP GreenScreen HC assay. | 2013 | Mutat. Res. | pmid:23340162 |
Zhou G et al. | HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23341636 |
Chan ST et al. | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | 2013 | PLoS ONE | pmid:23342112 |