trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
| Yang X et al. | CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. | 2009 | PLoS ONE | pmid:19340297 |
| Liu W et al. | HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. | 2012 | PLoS ONE | pmid:23152903 |
| Li L et al. | In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. | 2016 | PLoS ONE | pmid:26900852 |
| Meester-Smoor MA et al. | The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation. | 2011 | PLoS ONE | pmid:21949683 |
| Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
| Ying H et al. | Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. | 2012 | PLoS ONE | pmid:23166597 |
| Bennett KL et al. | AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. | 2009 | PLoS ONE | pmid:19742317 |
| Cui Y et al. | Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. | 2015 | PLoS ONE | pmid:26710276 |
| Pichugin A et al. | Ring-like distribution of constitutive heterochromatin in bovine senescent cells. | 2011 | PLoS ONE | pmid:22132080 |
| Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
| Zhao TC et al. | HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. | 2013 | PLoS ONE | pmid:23762381 |
| de Souza CF et al. | Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. | 2012 | PLoS ONE | pmid:22984562 |
| Otsuji TG et al. | Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes. | 2012 | PLoS ONE | pmid:22984602 |
| Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
| Liu H et al. | The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. | 2014 | PLoS ONE | pmid:24984019 |
| Charni Chaabane S et al. | PDGF-D expression is down-regulated by TGFβ in fibroblasts. | 2014 | PLoS ONE | pmid:25280005 |
| Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
| Sar P et al. | 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. | 2011 | PLoS ONE | pmid:21687737 |
| Yang DH et al. | Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. | 2014 | PLoS ONE | pmid:24846135 |
| Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
| Chang YW and Singh KP | Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells. | 2017 | PLoS ONE | pmid:28323900 |
| Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
| Sun S et al. | Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. | 2014 | PLoS ONE | pmid:24626188 |
| Halsall J et al. | Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. | 2012 | PLoS ONE | pmid:22479401 |
| Kim HR et al. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. | 2016 | PLoS ONE | pmid:27855185 |
| Morinobu A et al. | Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. | 2016 | PLoS ONE | pmid:27736946 |
| Tian Y et al. | Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. | 2013 | PLoS ONE | pmid:24367661 |
| Rajasingh J et al. | Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. | 2011 | PLoS ONE | pmid:21799893 |
| Zhang YW et al. | Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | 2012 | PLoS ONE | pmid:22701735 |
| Tong Y et al. | PTTG1 attenuates drug-induced cellular senescence. | 2011 | PLoS ONE | pmid:21858218 |
| Frye M et al. | Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. | 2007 | PLoS ONE | pmid:17712411 |
| Smith S et al. | Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. | 2014 | PLoS ONE | pmid:24466340 |
| Kondo Y et al. | Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. | 2014 | PLoS ONE | pmid:25084468 |
| Jagirdar K et al. | The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. | 2013 | PLoS ONE | pmid:24223135 |
| Wang JP et al. | Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. | 2011 | PLoS ONE | pmid:21901157 |
| Liu Y et al. | Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development. | 2013 | PLoS ONE | pmid:24223801 |
| Anantharaju PG et al. | Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). | 2017 | PLoS ONE | pmid:29190639 |
| Camolotto SA et al. | PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins. | 2013 | PLoS ONE | pmid:23418492 |
| Chachadi VB et al. | Prostatic cell-specific regulation of the synthesis of MUC1-associated sialyl Lewis a. | 2013 | PLoS ONE | pmid:23451223 |
| Kuan CS et al. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. | 2016 | PLoS ONE | pmid:26807725 |
| Spin JM et al. | Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. | 2010 | PLoS ONE | pmid:21179216 |
| Estella C et al. | Inhibition of histone deacetylase activity in human endometrial stromal cells promotes extracellular matrix remodelling and limits embryo invasion. | 2012 | PLoS ONE | pmid:22291969 |
| Palazzese L et al. | Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts. | 2018 | PLoS ONE | pmid:29543876 |
| Zhang P et al. | Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. | 2015 | PLoS ONE | pmid:26287365 |
| Ignatius MS et al. | Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. | 2013 | PLoS ONE | pmid:23667588 |
| Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
| Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
| Nunes MJ et al. | Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. | 2013 | PLoS ONE | pmid:23326422 |
| Chan ST et al. | Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. | 2013 | PLoS ONE | pmid:23342112 |