Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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You BR and Park WH | Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. | 2013 | Int. J. Oncol. | pmid:23165748 |
Doherty R et al. | Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC). | 2013 | Vet. Immunol. Immunopathol. | pmid:23764468 |
Chen X et al. | The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. | 2013 | Cell Death Dis | pmid:24157878 |
Jiao F et al. | Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. | 2013 | Stem Cells Dev. | pmid:23750509 |
Tian Y et al. | Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. | 2013 | PLoS ONE | pmid:24367661 |
Sachweh MC et al. | Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. | 2013 | Cell Death Dis | pmid:23470540 |
Arbuckle JH et al. | Mapping the telomere integrated genome of human herpesvirus 6A and 6B. | 2013 | Virology | pmid:23648233 |
Iwashita J et al. | Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes. | 2013 | Dev. Growth Differ. | pmid:23346879 |
Ji Q et al. | Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. | 2013 | Theriogenology | pmid:23347745 |
Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
Wu TC et al. | Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22626855 |
Kim YS et al. | Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22634317 |
Yang G et al. | Trichostatin a promotes cardiomyocyte differentiation of rat mesenchymal stem cells after 5-azacytidine induction or during coculture with neonatal cardiomyocytes via a mechanism independent of histone deacetylase inhibition. | 2012 | Cell Transplant | pmid:21944777 |
Kadaja-Saarepuu L et al. | Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. | 2012 | Int. J. Oncol. | pmid:21947346 |
Ekici M et al. | Chromatin structure and expression of the AMPA receptor subunit Glur2 in human glioma cells: major regulatory role of REST and Sp1. | 2012 | J. Cell. Biochem. | pmid:21948504 |
Rosborough BR et al. | Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. | 2012 | J. Leukoc. Biol. | pmid:22028329 |
Ying H et al. | Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. | 2012 | PLoS ONE | pmid:23166597 |
Londhe P et al. | CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells. | 2012 | Int. J. Cancer | pmid:21989738 |
Tsuboi H et al. | Epigenetic memory of DNAi associated with cytosine methylation and histone modification in fern. | 2012 | Plant Signal Behav | pmid:22990449 |
Anh TD et al. | The histone deacetylase inhibitor, Trichostatin A, induces G2/M phase arrest and apoptosis in YD-10B oral squamous carcinoma cells. | 2012 | Oncol. Rep. | pmid:21993600 |
Gillespie J et al. | Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. | 2012 | Arthritis Rheum. | pmid:21952924 |
Grabiec AM et al. | Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. | 2012 | Ann. Rheum. Dis. | pmid:21953341 |
Maroni P et al. | Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23085045 |
Icardi L et al. | Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2. | 2012 | FASEB J. | pmid:21957129 |
Dar RD et al. | Transcriptional burst frequency and burst size are equally modulated across the human genome. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23064634 |
Yang Q et al. | Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23043075 |
Fan H et al. | Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | 2012 | Epigenetics | pmid:23092945 |
Hirata Y et al. | Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22321215 |
Sawai K et al. | Epigenetic status and full-term development of bovine cloned embryos treated with trichostatin A. | 2012 | J. Reprod. Dev. | pmid:22322145 |
Banerjee A et al. | Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22298527 |
Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
Li H et al. | Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. | 2012 | Diabetes | pmid:22338096 |
Duncan HF et al. | Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells. | 2012 | J Endod | pmid:22341071 |
Kohda T et al. | Gene expression profile normalization in cloned mice by trichostatin A treatment. | 2012 | Cell Reprogram | pmid:22257163 |
Drzewiecka H and Jagodzinski PP | Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22257695 |
Shah S et al. | Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. | 2012 | Cancer Res. | pmid:22258452 |
Cho JS et al. | Epigenetic regulation of myofibroblast differentiation and extracellular matrix production in nasal polyp-derived fibroblasts. | 2012 | Clin. Exp. Allergy | pmid:22239687 |
Börner C et al. | Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. | 2012 | Neuroimmunomodulation | pmid:22262103 |
Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
Wang B et al. | Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. | 2012 | Free Radic. Biol. Med. | pmid:22226832 |
Liu H et al. | Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells. | 2012 | Acta Neurobiol Exp (Wars) | pmid:23377267 |
Barrasa JI et al. | Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells. | 2012 | Biochim. Biophys. Acta | pmid:22227581 |
Becker JR et al. | In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. | 2012 | Cardiovasc. Res. | pmid:22198505 |
Hsu YF et al. | Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. | 2012 | Biochim. Biophys. Acta | pmid:22155142 |
Bebenek IG et al. | CYP2S1 is negatively regulated by corticosteroids in human cell lines. | 2012 | Toxicol. Lett. | pmid:22155357 |
Sakuma Y et al. | WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. | 2012 | Lab. Invest. | pmid:22157722 |
Schor IE et al. | Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. | 2012 | PLoS ONE | pmid:23152763 |
Chang J et al. | Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. | 2012 | Br. J. Cancer | pmid:22158273 |
Calfa G et al. | HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. | 2012 | Hippocampus | pmid:22161912 |
Horvat T et al. | Epigenetic modulation of the HeLa cell membrane N-glycome. | 2012 | Biochim. Biophys. Acta | pmid:22192783 |
Shen YC et al. | The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. | 2012 | Dev. Biol. | pmid:22210003 |
Zhang CZ et al. | Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma. | 2012 | Cell Cycle | pmid:22214764 |
Kadowaki M et al. | DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. | 2012 | Int. J. Cancer | pmid:21437897 |
Scholl C et al. | Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain. | 2012 | BMC Genomics | pmid:22748179 |
Soleymani Fard S et al. | Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6). | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749740 |
Brose RD et al. | Activation of the stress proteome as a mechanism for small molecule therapeutics. | 2012 | Hum. Mol. Genet. | pmid:22752410 |
Jasek E et al. | Effect of histone deacetylase inhibitors trichostatin A and valproic acid on etoposide-induced apoptosis in leukemia cells. | 2012 | Anticancer Res. | pmid:22753739 |
Gan L et al. | Histone deacetylases regulate gonadotropin-releasing hormone I gene expression via modulating Otx2-driven transcriptional activity. | 2012 | PLoS ONE | pmid:22761896 |
Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
Tu Z et al. | The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression. | 2012 | Mol. Cell. Biochem. | pmid:22476901 |
Halsall J et al. | Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. | 2012 | PLoS ONE | pmid:22479401 |
Huang D et al. | A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study. | 2012 | Eur J Med Chem | pmid:22465091 |
Chuma M et al. | Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer. | 2012 | Biol. Pharm. Bull. | pmid:22466564 |
Li J et al. | Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. | 2012 | Nat. Med. | pmid:22466704 |
Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
Shen T et al. | Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22138223 |
Rossi LE et al. | Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. | 2012 | J. Leukoc. Biol. | pmid:22124136 |
Landreville S et al. | Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. | 2012 | Clin. Cancer Res. | pmid:22038994 |
Kim Y et al. | Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. | 2012 | J. Biol. Chem. | pmid:22679019 |
Royce SG et al. | Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice. | 2012 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:22684086 |
Zhang YW et al. | Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. | 2012 | PLoS ONE | pmid:22701735 |
Mitchell MD et al. | Epigenetic regulation of cytokine production in human amnion and villous placenta. | 2012 | Mediators Inflamm. | pmid:22665947 |
Buurman R et al. | Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. | 2012 | Gastroenterology | pmid:22641068 |
Orlova DY et al. | Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. | 2012 | J. Cell. Biochem. | pmid:22644811 |
Glait-Santar C et al. | Expression pattern of SVEP1 alternatively-spliced forms. | 2012 | Gene | pmid:22659106 |
Xiong H et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. | 2012 | Mol. Carcinog. | pmid:21520296 |
Park J et al. | ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22580278 |
Yin Z et al. | Position effect variegation and epigenetic modification of a transgene in a pig model. | 2012 | Genet. Mol. Res. | pmid:22370938 |
Halldórsdóttir AM et al. | Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. | 2012 | Am. J. Hematol. | pmid:22374828 |
Schnichels S et al. | Trichostatin A induces cell death at the concentration recommended to differentiate the RGC-5 cell line. | 2012 | Neurochem. Int. | pmid:22391323 |
Chan JN et al. | Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. | 2012 | Mol. Cell Proteomics | pmid:22357554 |
Fan LX et al. | Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. | 2012 | Kidney Int. | pmid:21900881 |
Zhu L et al. | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. | 2012 | Pediatr. Pulmonol. | pmid:21905265 |
Pufahl L et al. | Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. | 2012 | J. Cell. Mol. Med. | pmid:21883892 |
Li L et al. | Regulation of histone acetylation by NDRG2 in glioma cells. | 2012 | J. Neurooncol. | pmid:21912936 |
Yang F et al. | Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte. | 2012 | Int. J. Dev. Biol. | pmid:23417411 |
Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
Jee BC et al. | Effect of trichostatin A on fertilization and embryo development during extended culture of mouse oocyte. | 2012 | Zygote | pmid:21269543 |
SustáÄková G et al. | Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. | 2012 | J. Cell. Physiol. | pmid:21732356 |
Zhang QC et al. | Histone deacetylase inhibitor trichostatin A enhances anti-tumor effects of docetaxel or erlotinib in A549 cell line. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22994780 |
Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
He M and Guo Q | [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22561570 |
Catalano MG et al. | Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22563106 |
Yu L et al. | Trichostatin A ameliorates myocardial ischemia/reperfusion injury through inhibition of endoplasmic reticulum stress-induced apoptosis. | 2012 | Arch. Med. Res. | pmid:22564421 |
Bobkov DE et al. | [Isolation of tropomyosin particles from the cytosol of cultured cells and their protein composition analysis]. | 2012 | Tsitologiia | pmid:22567898 |
Li Q and Chen H | Silencing of Wnt5a during colon cancer metastasis involves histone modifications. | 2012 | Epigenetics | pmid:22522911 |