| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
| An JH et al. | The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells. | 2014 | FEBS Lett. | pmid:25281925 |
| Han RF et al. | Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. | 2014 | Mol Med Rep | pmid:25269990 |
| Boucher J et al. | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246545 |
| Wang BY et al. | Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. | 2014 | Pharmacol. Biochem. Behav. | pmid:25242807 |
| Wang B et al. | Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. | 2014 | Oncol. Rep. | pmid:25224651 |
| Svegliati S et al. | Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. | 2014 | Sci Signal | pmid:25185156 |
| Srirattana K et al. | Effects of trichostatin A on In vitro development and DNA methylation level of the satellite I region of swamp buffalo (Bubalus bubalis) cloned embryos. | 2014 | J. Reprod. Dev. | pmid:24909601 |
| Wang Y et al. | Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. | 2014 | Int. J. Mol. Med. | pmid:24888454 |
| Chan ST et al. | Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo. | 2014 | Biomed Res Int | pmid:24868531 |
| Kiliccioglu I et al. | Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. | 2014 | Genet. Mol. Res. | pmid:24854658 |
| Peiffer L et al. | Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation. | 2014 | J. Cancer Res. Clin. Oncol. | pmid:24793644 |
| Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
| Balmer NV et al. | From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. | 2014 | Arch. Toxicol. | pmid:24935251 |
| Yuan TF et al. | The epigenetics changes in Parkinson's disease: a novel therapeutic target. | 2014 | CNS Neurosci Ther | pmid:24629108 |
| Sun S et al. | Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. | 2014 | PLoS ONE | pmid:24626188 |
| Saayman S et al. | An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. | 2014 | Mol. Ther. | pmid:24576854 |
| McEachern LA and Murphy PR | Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus. | 2014 | Mol. Endocrinol. | pmid:24552587 |
| Sakharkar AJ et al. | Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24528596 |
| Kong Q et al. | Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by somatic cell nuclear transfer. | 2014 | Stem Cell Rev | pmid:24510582 |
| Maleszewska M et al. | The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells. | 2014 | Pharmacol Rep | pmid:24905315 |
| Saccone V et al. | HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. | 2014 | Genes Dev. | pmid:24682306 |
| Alcarraz-Vizán G et al. | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. | 2014 | Biochim. Biophys. Acta | pmid:24368265 |
| Xie M et al. | Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. | 2014 | Circulation | pmid:24396039 |
| Koriyama Y et al. | Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. | 2014 | J. Pharmacol. Sci. | pmid:24389816 |
| Blank M et al. | Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus. | 2014 | Neurobiol Learn Mem | pmid:24583371 |
| Iancu-Rubin C and Hoffman R | Role of epigenetic reprogramming in hematopoietic stem cell function. | 2015 | Curr. Opin. Hematol. | pmid:26049747 |
| Pandey SC et al. | Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. | 2015 | Neurobiol. Dis. | pmid:25814047 |
| Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
| Asaoka N et al. | Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. | 2015 | Neurosci. Lett. | pmid:25796177 |
| Butler PL et al. | Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. | 2015 | J. Biol. Chem. | pmid:25787079 |
| Jiang H et al. | Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. | 2015 | Acta Histochem. | pmid:25480399 |
| Du J et al. | HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. | 2015 | J. Cell. Physiol. | pmid:25475100 |
| Xu T and Hu X | Copper-catalyzed 1,2-addition of α-carbonyl iodides to alkynes. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470461 |
| Rabineau M et al. | Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. | 2015 | Biomaterials | pmid:25453945 |
| Cui Y et al. | Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. | 2015 | PLoS ONE | pmid:26710276 |
| Chahine MN et al. | Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts. | 2015 | Cardiovasc. Res. | pmid:25341891 |
| Ji M et al. | HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. | 2015 | Oncol. Rep. | pmid:25813246 |
| Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
| Wang Y et al. | Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats. | 2015 | J. Mol. Neurosci. | pmid:24829091 |
| Li Z et al. | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. | 2015 | Gastric Cancer | pmid:24481854 |
| Perez-Janices N et al. | Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. | 2015 | Oncotarget | pmid:26284587 |
| Keil KP et al. | Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. | 2015 | Dev. Dyn. | pmid:26283270 |
| Hsing CH et al. | Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. | 2015 | Mediators Inflamm. | pmid:26273133 |
| Zhou L et al. | Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. | 2015 | J. Virol. | pmid:26269170 |
| Kaldre D et al. | Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. | 2015 | Bioorg. Med. Chem. | pmid:26048026 |
| Liu Y and Li S | A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. | 2015 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:26022499 |
| Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |
| Koppaka V et al. | Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. | 2015 | Mol. Vis. | pmid:25999677 |
| Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |