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Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. |
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The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. |
2012 |
Reproduction |
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2012 |
Diabetes |
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PLoS ONE |
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Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. |
2011 Sep-Oct |
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2011 Oct-Dec |
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DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. |
2011 Nov-Dec |
Mol Med Rep |
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Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. |
2011 Jan-Feb |
Nucleus |
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Elucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell lines. |
2011 |
Neoplasia |
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Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. |
2011 |
ACS Med Chem Lett |
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Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. |
2011 |
Physiol. Genomics |
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Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma. |
2011 |
Int. J. Cancer |
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Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. |
2011 |
Int. J. Cancer |
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Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. |
2011 |
Circ. Res. |
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Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. |
2011 |
Biochem. Biophys. Res. Commun. |
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J. Assist. Reprod. Genet. |
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2011 |
PLoS ONE |
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Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. |
2011 |
Am. J. Respir. Cell Mol. Biol. |
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Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma. |
2011 |
Neuro Endocrinol. Lett. |
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HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1. |
2011 |
Ann. N. Y. Acad. Sci. |
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SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. |
2011 |
BMC Cancer |
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Structure-based optimization of click-based histone deacetylase inhibitors. |
2011 |
Eur J Med Chem |
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Valproic acid phase shifts the rhythmic expression of Period2::Luciferase. |
2011 |
J. Biol. Rhythms |
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The histone acetyltransferase p300 promotes intrinsic axonal regeneration. |
2011 |
Brain |
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Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. |
2011 |
Cancer Biol. Ther. |
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Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. |
2011 |
Lipids |
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Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. |
2011 |
Exp. Neurol. |
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3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. |
2011 |
PLoS ONE |
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Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. |
2011 |
Org. Lett. |
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Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. |
2011 |
Plant Cell Physiol. |
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Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes. |
2011 |
Mol. Cell. Endocrinol. |
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ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. |
2011 |
Physiol Plant |
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HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells. |
2011 |
Curr. HIV Res. |
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Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. |
2011 |
Cell Biol. Int. |
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Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. |
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Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. |
2011 |
Nucleic Acids Res. |
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A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. |
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J. Cell. Sci. |
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DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. |
2011 |
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Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. |
2011 |
PLoS ONE |
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Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis. |
2011 |
Mod. Pathol. |
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Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. |
2011 |
J. Clin. Immunol. |
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Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. |
2011 |
Int. J. Oncol. |
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Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment. |
2011 |
Differentiation |
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Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. |
2011 |
Hepatology |
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Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. |
2011 |
Immunol. Cell Biol. |
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Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. |
2011 |
Blood |
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The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells. |
2011 |
J. Cell. Physiol. |
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The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli. |
2011 |
Plant Cell Physiol. |
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Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β-thalassemia fibroblasts. |
2011 |
Stem Cells Dev. |
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Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos. |
2011 |
In Vitro Cell. Dev. Biol. Anim. |
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Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. |
2011 |
Mol. Cell. Biochem. |
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EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. |
2011 |
Mol. Cancer Res. |
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[Study of RASSF1A expression and promoter demethylation in Hep-2 cell line]. |
2011 |
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi |
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Trichostatin A modulates apoptotic-related gene expression and improves embryo viability in cloned bovine embryos. |
2011 |
Cell Reprogram |
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Chen X et al. |
Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents. |
2011 |
Molecules |
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Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. |
2011 |
Clin Lymphoma Myeloma Leuk |
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[TSA improve transgenic porcine cloned embryo development and transgene expression]. |
2011 |
Yi Chuan |
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Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. |
2011 |
Exp. Biol. Med. (Maywood) |
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Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. |
2011 |
Mol. Cell. Endocrinol. |
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Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. |
2011 |
Am. J. Respir. Cell Mol. Biol. |
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Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. |
2011 |
Epigenetics |
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Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. |
2011 |
Cancer Res. |
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Zhang CZ et al. |
Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. |
2011 |
Apoptosis |
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Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. |
2011 |
Spine |
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Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos. |
2011 |
J. Reprod. Dev. |
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Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. |
2011 |
PLoS ONE |
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Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. |
2011 |
Oncogene |
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Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. |
2011 |
Mol. Cell. Biol. |
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TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. |
2011 |
Epigenetics |
pmid:21847011
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Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos. |
2011 |
J. Reprod. Dev. |
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Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. |
2011 |
PLoS ONE |
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Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. |
2011 |
Epigenetics |
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γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. |
2011 |
Int. J. Radiat. Biol. |
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Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells. |
2011 |
Cancer |
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Jackson K et al. |
Epigenetic silencing of somatostatin in gastric cancer. |
2011 |
Dig. Dis. Sci. |
pmid:20927589
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Sahu GK and Cloyd MW |
Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors. |
2011 |
Virol. J. |
pmid:21838863
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Yu D et al. |
Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. |
2011 |
Bioorg. Med. Chem. Lett. |
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Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. |
2011 |
Am. J. Hematol. |
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Histone deacetylase inhibitors increase human arylamine N-acetyltransferase-1 expression in human tumor cells. |
2011 |
Drug Metab. Dispos. |
pmid:20870783
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Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. |
2011 |
PLoS ONE |
pmid:21901157
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Zou CF et al. |
Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. |
2011 |
BMC Cancer |
pmid:21244707
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Puppin C et al. |
In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription. |
2011 |
Cell Oncol (Dordr) |
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Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction. |
2011 |
J. Immunol. |
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Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. |
2011 |
Cancer |
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Histone deacetylation directs DNA methylation in survivin gene silencing. |
2011 |
Biochem. Biophys. Res. Commun. |
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Nucleophosmin delocalization in thyroid tumour cells. |
2011 |
Endocr. Pathol. |
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Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. |
2011 |
Cell Reprogram |
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Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. |
2011 |
Bioorg. Med. Chem. |
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Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. |
2011 |
Mol. Biol. Rep. |
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Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature. |
2011 |
Biochim. Biophys. Acta |
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Histone deacetylase inhibitors control the transcription and alternative splicing of prohibitin in thyroid tumor cells. |
2011 |
Oncol. Rep. |
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Interplay between PKCδ and Sp1 on histone deacetylase inhibitor-mediated Epstein-Barr virus reactivation. |
2011 |
J. Virol. |
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Nandakumar V et al. |
(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. |
2011 |
Carcinogenesis |
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Kang H and Roh S |
Extended exposure to trichostatin A after activation alters the expression of genes important for early development in nuclear transfer murine embryos. |
2011 |
J. Vet. Med. Sci. |
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Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. |
2011 |
Surgery |
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Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. |
2011 |
J. Biol. Chem. |
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