trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Asthma D001249 52 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Body Weight D001835 333 associated lipids
Brain Neoplasms D001932 15 associated lipids
Breast Neoplasms D001943 24 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Cat Diseases D002371 12 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Chondrosarcoma D002813 9 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Park H et al. Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. 2008 Int. J. Mol. Med. pmid:18949380
Dowling DP et al. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. 2008 Biochemistry pmid:19053282
Ishii T et al. [Epigenetic regulation in alcohol-related brain damage]. 2008 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:19068777
Gray SG et al. Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. 2008 Clin Lung Cancer pmid:19073520
Zhu K et al. Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. 2008 Arch. Gynecol. Obstet. pmid:17680259
Chou CW and Chen CC HDAC inhibition upregulates the expression of angiostatic ADAMTS1. 2008 FEBS Lett. pmid:19007777
Nair S et al. Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. 2008 Pharm. Res. pmid:17657594
Setiadi AF et al. Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. 2008 Cancer Res. pmid:19047136
Zhou Q et al. Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells. 2008 Mol. Vis. pmid:19122829
Meng CF et al. [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP]. 2008 Ai Zheng pmid:19079988
Usami M et al. Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. 2008 Nutr Res pmid:19083427
Krämer OH et al. Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. 2008 Oncogene pmid:17653085
Tanaka M et al. The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination. 2008 Plant Physiol. pmid:18024558
Hajji N et al. Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. 2008 Oncogene pmid:18071312
Walton TJ et al. DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. 2008 Prostate pmid:18092350
Arany I et al. Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. 2008 Am. J. Physiol. Renal Physiol. pmid:18094030
Jiemjit A et al. p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. 2008 Oncogene pmid:18223691
Nasu Y et al. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. 2008 Osteoarthr. Cartil. pmid:18226559
Lim HG et al. Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. 2008 Mol. Ther. pmid:18227841
Ruau D et al. Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. 2008 Stem Cells pmid:18203677
Serrano E et al. Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. 2008 Leuk. Res. pmid:18206229
Hamner JB et al. The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. 2008 J. Pediatr. Surg. pmid:18206478
Duhamel M et al. Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. 2008 FEBS Lett. pmid:18206652
Joseph RA et al. Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking. 2008 Hepatology pmid:18161881
Shi LH et al. Trichostatin A and nuclear reprogramming of cloned rabbit embryos. 2008 J. Anim. Sci. pmid:18245503
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Byers J and Eichinger D Acetylation of the Entamoeba histone H4 N-terminal domain is influenced by short-chain fatty acids that enter trophozoites in a pH-dependent manner. 2008 Int. J. Parasitol. pmid:17706222
Campanero MR et al. The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. 2008 Oncogene pmid:17724474
Manning J et al. Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. 2008 Immunology pmid:17725605
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Pan J et al. TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. 2008 Mol. Cancer Res. pmid:18505930
Hou J et al. Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation. 2008 BMC Dev. Biol. pmid:18507869
Dalgard CL et al. Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. 2008 Clin. Cancer Res. pmid:18483379
Egler V et al. Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death. 2008 Clin. Cancer Res. pmid:18483381
Chen Y et al. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. 2008 J. Med. Chem. pmid:18494463
Fantini D et al. APE1/Ref-1 regulates PTEN expression mediated by Egr-1. 2008 Free Radic. Res. pmid:18324520
Kang JH et al. CCAAT box is required for the induction of human thrombospondin-1 gene by trichostatin A. 2008 J. Cell. Biochem. pmid:18275041
Oliva J et al. Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. 2008 Exp. Mol. Pathol. pmid:18280469
Nakamura C et al. Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. 2008 Rheumatology (Oxford) pmid:18281366
Yu C et al. Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. 2008 Neuro-oncology pmid:18445700
Yu WP et al. Induction of ID1 expression and apoptosis by the histone deacetylase inhibitor (trichostatin A) in human acute myeloid leukaemic cells. 2008 Cell Prolif. pmid:18211287
Jensen TJ et al. Epigenetic remodeling during arsenical-induced malignant transformation. 2008 Carcinogenesis pmid:18448484
Kikuno N et al. Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. 2008 Int. J. Cancer pmid:18431742
van West P et al. Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling. 2008 Microbiology (Reading, Engl.) pmid:18451057
Zhang HJ et al. Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. 2008 Placenta pmid:18440631
Liu Z et al. Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. 2008 Oncol. Rep. pmid:18575731
Meja KK et al. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. 2008 Am. J. Respir. Cell Mol. Biol. pmid:18421014
Plouffe D et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18579783
Sebastián C et al. Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. 2008 J. Immunol. pmid:18424709
Sun Y et al. Modulation of transcription parameters in glucocorticoid receptor-mediated repression. 2008 Mol. Cell. Endocrinol. pmid:18583028
Tshuikina M et al. Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. 2008 Exp. Hematol. pmid:18922617
Biacsi R et al. SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. 2008 PLoS Genet. pmid:18369442
Hishikawa K and Fujita T [Kidney regeneration update]. 2008 Nippon Rinsho pmid:18464514
Wu X et al. Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. 2008 Anim. Biotechnol. pmid:18855246
Lindström TM et al. Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells. 2008 Mol. Pharmacol. pmid:18375836
Kato A et al. Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. 2008 Exp. Cell Res. pmid:18588874
Li J et al. High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. 2008 Theriogenology pmid:18573521
Xu ZM et al. The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage. 2008 BMB Rep pmid:18377727
Chen CJ et al. Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells. 2008 Eur. J. Pharmacol. pmid:18590721
Karantzali E et al. Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis. 2008 Genome Biol. pmid:18394158
Marengo E et al. Evaluation of the variables characterized by significant discriminating power in the application of SIMCA classification method to proteomic studies. 2008 J. Proteome Res. pmid:18543959
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Galiová G et al. Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. 2008 Eur. J. Cell Biol. pmid:18396346
Zhu X et al. Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells. 2008 J. Clin. Endocrinol. Metab. pmid:18544619
Gaviraghi M et al. Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene. 2008 BMC Mol. Biol. pmid:18549468
Mühlethaler-Mottet A et al. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. 2008 Mol. Cancer pmid:18549473
Kim B et al. Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. 2008 Eur. J. Pharmacol. pmid:18550052
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Lee TB et al. Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. 2008 BMC Gastroenterol pmid:18673531
Iager AE et al. Trichostatin A improves histone acetylation in bovine somatic cell nuclear transfer early embryos. 2008 Cloning Stem Cells pmid:18419249
Liu TC et al. Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. 2008 Mol. Ther. pmid:18388912
Reilly CM et al. The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. 2008 J. Autoimmun. pmid:18650065
Pluemsampant S et al. Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. 2008 Int. J. Cancer pmid:17935135
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Duan H et al. Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. 2008 Oncogene pmid:18695675
Ding X et al. Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. 2008 Theriogenology pmid:18556056
Jia J and Chen J Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. 2008 Pharmazie pmid:18557424
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Narver HL et al. Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. 2008 Ann. Neurol. pmid:18661558
Yu J et al. Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. 2008 Hepatology pmid:18666234
Iacobazzi V et al. Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. 2008 Biochem. Biophys. Res. Commun. pmid:18706393
Falk M et al. Chromatin structure influences the sensitivity of DNA to gamma-radiation. 2008 Biochim. Biophys. Acta pmid:18706456
Zhang XH et al. Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer. 2008 Cancer Biol. Ther. pmid:18708766
Carlisi D et al. Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. 2008 Int. J. Oncol. pmid:18097557
Seo JS et al. Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin A. 2008 Oncol. Rep. pmid:18097580
Yeh JR et al. AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. 2008 Development pmid:18156164
Liu F et al. Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. 2008 J. Mol. Cell. Cardiol. pmid:18926829
Gu Z et al. Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. 2008 Genes Genet. Syst. pmid:18931460
Yoshioka H et al. Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. 2008 J. Biol. Chem. pmid:18801729
Wu Y and Guo SW Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. 2008 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:17376583
Jin B et al. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. 2008 Hum. Mol. Genet. pmid:18029387
Gan Y et al. Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells. 2008 Biochem. Biophys. Res. Commun. pmid:17996726
Han JQ et al. [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. 2008 Zhonghua Gan Zang Bing Za Zhi pmid:18822204
Pellicciotta I et al. Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. 2008 Cancer Res. pmid:18829567
Hitchler MJ et al. Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. 2008 Free Radic. Biol. Med. pmid:18845242