trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Asthma D001249 52 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Biliary Tract Neoplasms D001661 7 associated lipids
Body Weight D001835 333 associated lipids
Brain Neoplasms D001932 15 associated lipids
Breast Neoplasms D001943 24 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Cat Diseases D002371 12 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Chondrosarcoma D002813 9 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Chen J and Kang JH Quercetin and trichostatin A cooperatively kill human leukemia cells. 2005 Pharmazie pmid:16320950
Blagosklonny MV et al. Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. 2005 Cancer Res. pmid:16103091
Choi JH et al. Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16141407
Krouwels IM et al. A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. 2005 J. Cell Biol. pmid:16103223
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Yanada M et al. Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. 2005 Oncol. Rep. pmid:16142337
Schmittwolf C et al. In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. 2005 EMBO J. pmid:15660132
Kang J et al. Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. 2005 Toxicol In Vitro pmid:15649630
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Munshi A et al. Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. 2005 Clin. Cancer Res. pmid:16000590
Sng JC et al. Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. 2005 Neurosci. Lett. pmid:16002216
Shetty S et al. Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. 2005 Mol. Cell. Biol. pmid:15964798
Komata T et al. Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. 2005 Int. J. Oncol. pmid:15809727
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Kondo T et al. Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. 2005 Oncogene pmid:15637589
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Wang LG et al. Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. 2004 Oncogene pmid:15156193
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Bayart E et al. A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. 2004 Cancer Res. pmid:15604258
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Winn RA and Heasley LE Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. 2004 Chest pmid:15136458
Jin YH et al. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. 2004 J. Biol. Chem. pmid:15138260
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Chang HC et al. Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. 2004 Cell. Signal. pmid:15093608
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Arapshian A et al. Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. 2004 Mol. Cancer pmid:15113415
Mizukami T et al. Effects of trichostatin a, a histone deacetylase inhibitor, on mouse gonadal development in vitro. 2004 J. Reprod. Dev. pmid:15118250
Ganslmayer M et al. A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. 2004 Oncol. Rep. pmid:15069530
Margueron R et al. Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. 2004 J. Mol. Endocrinol. pmid:15072561
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Chua YL et al. Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. 2004 Plant J. pmid:14996214
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Zelko IN and Folz RJ Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. 2004 Free Radic. Biol. Med. pmid:15451065
Chiba T et al. Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. 2004 Oncology pmid:15452378
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Uramoto H et al. p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. 2004 J. Cell. Sci. pmid:15454570
Wang S and Zhu J The hTERT gene is embedded in a nuclease-resistant chromatin domain. 2004 J. Biol. Chem. pmid:15516693
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Vaquero A et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. 2004 Mol. Cell pmid:15469825
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Li H and Wu X Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. 2004 Biochem. Biophys. Res. Commun. pmid:15474507
Spenger A et al. Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. 2004 Protein Expr. Purif. pmid:15477077
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Ng Y et al. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. 2004 J. Biol. Chem. pmid:15194684
Lu H et al. Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. 2004 J. Virol. pmid:15194748
Moldenhauer A et al. Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. 2004 J. Leukoc. Biol. pmid:15197237
Min KN et al. Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. 2004 Arch. Pharm. Res. pmid:15202563
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