trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Adenomyosis D062788 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Visceral Pain D059265 1 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Capsule Opacification D058442 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Atherosclerosis D050197 85 associated lipids
Genomic Instability D042822 7 associated lipids
Mastocytoma D034801 3 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Stroke D020521 32 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Ventricular Remodeling D020257 28 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Armstrong K et al. NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. 2006 Prostate pmid:16683270
Mavis CK et al. Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. 2009 Prostate pmid:19444856
Frønsdal K and Saatcioglu F Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. 2005 Prostate pmid:15389787
Walton TJ et al. DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. 2008 Prostate pmid:18092350
Soleymani Fard S et al. Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6). 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22749740
Viñuelas J et al. Towards experimental manipulation of stochasticity in gene expression. 2012 Prog. Biophys. Mol. Biol. pmid:22609563
Akiyama T et al. Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16651529
Chen WY and Townes TM Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10618426
Ma P et al. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22223663
Xu CR et al. Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16176989
Emiliani S et al. Characterization of a human RPD3 ortholog, HDAC3. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9501169
Kenneth NS et al. TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17848523
Condreay JP et al. Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874783
Crump NT et al. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21518915
Saito A et al. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10200307
Ji Y et al. A multistep mechanism for the activation of rearrangement in the immune system. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12802019
Jansen MS et al. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15103026
Furumai R et al. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11134513
McCullough SD et al. Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:23236151
Weaver IC et al. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16484373