trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin T et al. | Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver. | 2007 | Surgery | pmid:17560255 |
| Zarnegar R et al. | Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. | 2002 | Surgery | pmid:12490845 |
| Cogdill AP et al. | Targeting the MAGE A3 antigen in pancreatic cancer. | 2012 | Surgery | pmid:22770803 |
| Mitmaker EJ et al. | Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors. | 2011 | Surgery | pmid:21193210 |
| Awe S and Renkawitz-Pohl R | Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. | 2010 | Syst Biol Reprod Med | pmid:20170286 |
| [Isolation of drug-resistant mutant cells]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1745788 | |
| Yoshida M and Horinouchi S | [Histone deacetylase inhibitors--new anticancer agents?]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10771678 |
| Yoshida M and Beppu T | [Trichostatins and leptomycins, new cell cycle inhibitors specific for G1 and G2 phases]. | 1989 | Tanpakushitsu Kakusan Koso | pmid:2678278 |
| Shimazu T et al. | [Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051411 |
| Yoshida M | [Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051427 |
| Yoshida M | [Molecular targets of cell cycle inhibitors and their mode of action]. | 1996 | Tanpakushitsu Kakusan Koso | pmid:8890633 |
| Cervera RP et al. | Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. | 2009 | Theriogenology | pmid:19765811 |
| Lee HS et al. | Enhanced histone acetylation in somatic cells induced by a histone deacetylase inhibitor improved inter-generic cloned leopard cat blastocysts. | 2010 | Theriogenology | pmid:20708232 |
| Wang YS et al. | Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. | 2011 | Theriogenology | pmid:21144561 |
| Shiratsuki S et al. | Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. | 2011 | Theriogenology | pmid:21144563 |
| Luo C et al. | Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. | 2013 | Theriogenology | pmid:24007823 |
| Shao GB et al. | Effect of trychostatin A treatment on gene expression in cloned mouse embryos. | 2009 | Theriogenology | pmid:19246084 |
| Li J et al. | High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. | 2008 | Theriogenology | pmid:18573521 |
| Opiela J et al. | In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells. | 2017 | Theriogenology | pmid:28583605 |
| Ji Q et al. | Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. | 2013 | Theriogenology | pmid:23347745 |