Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vecsey CG et al. | Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. | 2007 | J. Neurosci. | pmid:17553985 |
Pinnoji RC et al. | Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. | 2007 | Virol. J. | pmid:17555596 |
Khan Z et al. | HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. | 2007 | Exp. Cell Res. | pmid:17555745 |
Donadelli M et al. | Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | 2007 | Biochim. Biophys. Acta | pmid:17555830 |
Smetana K et al. | Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study. | 2007 | Acta Histochem. | pmid:17559910 |
Ye J et al. | De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists. | 2007 | J. Virol. | pmid:17596302 |
Tuncel M et al. | The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake. | 2007 | Cancer Biother. Radiopharm. | pmid:17600477 |
Cantor JP et al. | Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. | 2007 | Int. J. Cancer | pmid:17019711 |
Kaneko M et al. | Mechanism for the differentiation of EoL-1 cells into eosinophils by histone deacetylase inhibitors. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541273 |
Schwechter BR et al. | Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17525221 |
Turaga RV et al. | Werner syndrome protein prevents DNA breaks upon chromatin structure alteration. | 2007 | Aging Cell | pmid:17521388 |
Wu J et al. | Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing. | 2007 | BMC Genomics | pmid:17524140 |
Wang LG et al. | Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. | 2007 | Mol. Carcinog. | pmid:16921492 |
Choy SW et al. | C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17506990 |
Royo H et al. | Bsr, a nuclear-retained RNA with monoallelic expression. | 2007 | Mol. Biol. Cell | pmid:17507654 |
Uchida H et al. | Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2007 | Endocrinology | pmid:17068141 |
Roy S and Tenniswood M | Site-specific acetylation of p53 directs selective transcription complex assembly. | 2007 | J. Biol. Chem. | pmid:17121856 |
Liu L and Clipstone NA | Prostaglandin F2alpha inhibits adipocyte differentiation via a G alpha q-calcium-calcineurin-dependent signaling pathway. | 2007 | J. Cell. Biochem. | pmid:16888802 |
Chen Y et al. | Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. | 2007 | Int. J. Cancer | pmid:17417779 |
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Hwang CK et al. | Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. | 2007 | Mol. Cell. Biol. | pmid:17452465 |
Piotrowska H and Jagodzinski PP | Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. | 2007 | Biomed. Pharmacother. | pmid:17498915 |
Iliopoulos D et al. | Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. | 2007 | Ann. Rheum. Dis. | pmid:17502362 |
Sato N et al. | RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. | 2007 | Int. J. Cancer | pmid:17096327 |
Vikhanskaya F et al. | Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53. | 2007 | Nucleic Acids Res. | pmid:17344317 |
Zhang R et al. | HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. | 2007 | Mol. Cell. Biol. | pmid:17101789 |
Krennhrubec K et al. | Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17346959 |
Vincent A et al. | Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells. | 2007 | Oncogene | pmid:17471237 |
Zhang C et al. | Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells. | 2007 | J. Pathol. | pmid:17471463 |
Gensert JM et al. | CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells. | 2007 | Neurobiol. Dis. | pmid:17481908 |
Mayo C et al. | In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression. | 2007 | J. Cell. Physiol. | pmid:17311291 |
Jung EJ et al. | Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir. | 2007 | Cancer Lett. | pmid:16647201 |
Avila AM et al. | Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. | 2007 | J. Clin. Invest. | pmid:17318264 |
Snykers S et al. | Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. | 2007 | BMC Dev. Biol. | pmid:17407549 |
Horion J et al. | Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha. | 2007 | J. Biol. Chem. | pmid:17409387 |
Ryningen A et al. | Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting. | 2007 | Leuk. Res. | pmid:17416413 |
Imai N et al. | Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. | 2007 | Stem Cells | pmid:17641247 |
Dai B and Rasmussen TP | Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. | 2007 | Stem Cells | pmid:17641388 |
Kaida D et al. | Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. | 2007 | Nat. Chem. Biol. | pmid:17643111 |
Kotake Y et al. | Splicing factor SF3b as a target of the antitumor natural product pladienolide. | 2007 | Nat. Chem. Biol. | pmid:17643112 |
Kang JH et al. | Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. | 2007 | Exp. Mol. Med. | pmid:17603295 |
Subramanian C et al. | CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. | 2007 | Neoplasia | pmid:17603632 |
Chen B and Cepko CL | Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. | 2007 | BMC Dev. Biol. | pmid:17603891 |
Glenisson W et al. | Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. | 2007 | Biochim. Biophys. Acta | pmid:17610967 |
Zhang X et al. | Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. | 2007 | Biochem. Cell Biol. | pmid:17612628 |
Shi J et al. | Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. | 2007 | Cancer Res. | pmid:17616702 |
Perales M and Más P | A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock. | 2007 | Plant Cell | pmid:17616736 |
Zhao Y et al. | Roles of histone acetylation modification in basal and inducible expression of hsp26 gene in D. melanogaster. | 2007 | Mol. Cell. Biochem. | pmid:17619947 |
El-Khoury V et al. | The histone deacetylase inhibitor trichostatin A downregulates human MDR1 (ABCB1) gene expression by a transcription-dependent mechanism in a drug-resistant small cell lung carcinoma cell line model. | 2007 | Br. J. Cancer | pmid:17667922 |
Khaw AK et al. | Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells. | 2007 | Mutat. Res. | pmid:17669439 |
Rouhi A et al. | Plasticity of Ly49g expression is due to epigenetics. | 2007 | Mol. Immunol. | pmid:16750269 |
Brest P et al. | Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. | 2007 | Cancer Res. | pmid:18056459 |
Sourlingas TG et al. | Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. | 2007 | Ann. N. Y. Acad. Sci. | pmid:18056955 |
Sekhavat A et al. | Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. | 2007 | Biochem. Cell Biol. | pmid:18059533 |
Seo H et al. | Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering. | 2007 | Biotechnol. Genet. Eng. Rev. | pmid:18059633 |
Mazières J et al. | Epigenetic regulation of RhoB loss of expression in lung cancer. | 2007 | BMC Cancer | pmid:18047684 |
Shimazu T et al. | [Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051411 |
Platta CS et al. | The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. | 2007 | J. Surg. Res. | pmid:17612559 |
Yoshida M | [Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051427 |
Mogal AP et al. | Haploinsufficient prostate tumor suppression by Nkx3.1: a role for chromatin accessibility in dosage-sensitive gene regulation. | 2007 | J. Biol. Chem. | pmid:17602165 |
Meng CF et al. | Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines. | 2007 | World J. Gastroenterol. | pmid:18069755 |
Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
Wu ZQ et al. | Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. | 2007 | Chin. Med. J. | pmid:18167185 |
Karam JA et al. | The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. | 2007 | Int. J. Cancer | pmid:17230511 |
Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
Januchowski R and Jagodzinski PP | Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. | 2007 | Int. Immunopharmacol. | pmid:17178387 |
Cras A et al. | Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. | 2007 | Oncogene | pmid:17213810 |
Rao J et al. | Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17869223 |
Karagiannis TC et al. | Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments. | 2007 | Oncogene | pmid:17213813 |
Ohoka N et al. | Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. | 2007 | J. Biol. Chem. | pmid:17872950 |
Elaut G et al. | A metabolic screening study of trichostatin A (TSA) and TSA-like histone deacetylase inhibitors in rat and human primary hepatocyte cultures. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17218485 |
Kenneth NS et al. | TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17848523 |
Ferreira R et al. | Site-specific acetylation of ISWI by GCN5. | 2007 | BMC Mol. Biol. | pmid:17760996 |
Jamaluddin MD et al. | Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. | 2007 | Blood | pmid:17698632 |
Ting CH et al. | Stat5 constitutive activation rescues defects in spinal muscular atrophy. | 2007 | Hum. Mol. Genet. | pmid:17220171 |
Hong S et al. | Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A. | 2007 | Anticancer Drugs | pmid:17704650 |
McCool KW et al. | The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation. | 2007 | J. Biol. Chem. | pmid:17204470 |
Bártová E et al. | Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites. | 2007 | Histochem. Cell Biol. | pmid:17205308 |
Kuang PP et al. | Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17209135 |
Lattal KM et al. | Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. | 2007 | Behav. Neurosci. | pmid:17907845 |
Yang H et al. | Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16973938 |
Zhang Y et al. | An epigenetic modifier results in improved in vitro blastocyst production after somatic cell nuclear transfer. | 2007 | Cloning Stem Cells | pmid:17907946 |
Noro R et al. | PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. | 2007 | Int. J. Oncol. | pmid:17912443 |
Zhao TC et al. | Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. | 2007 | Cardiovasc. Res. | pmid:17884027 |
Liu T et al. | Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. | 2007 | Carcinogenesis | pmid:16990345 |
Stapnes C et al. | Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. | 2007 | Int. J. Oncol. | pmid:17982680 |
Honda H et al. | Regulation of the CLDN3 gene in ovarian cancer cells. | 2007 | Cancer Biol. Ther. | pmid:17986852 |
Renthal W et al. | Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. | 2007 | Neuron | pmid:17988634 |
Carén H et al. | Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. | 2007 | Br. J. Cancer | pmid:17940511 |
Kim EJ et al. | Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. | 2007 | Mol. Cell | pmid:17964266 |
Shen L et al. | Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. | 2007 | PLoS Genet. | pmid:17967063 |
Stiehl DP et al. | Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation. | 2007 | Cancer Res. | pmid:17332356 |
Jung J and Bonini N | CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. | 2007 | Science | pmid:17332375 |
Jaffe RC et al. | Histone deacetylase inhibition and progesterone act synergistically to stimulate baboon glycodelin gene expression. | 2007 | J. Mol. Endocrinol. | pmid:17339403 |
Alimirah F et al. | IFI16 in human prostate cancer. | 2007 | Mol. Cancer Res. | pmid:17339605 |
Wu Y and Guo SW | Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells. | 2007 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17296257 |
Cao D et al. | COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17395887 |
Li Y et al. | Regulation of neuronal nitric oxide synthase exon 1f gene expression by nuclear factor-kappaB acetylation in human neuroblastoma cells. | 2007 | J. Neurochem. | pmid:17250678 |
Wee G et al. | Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. | 2007 | Reproduction | pmid:18042635 |