Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sachs LM et al. | An essential role of histone deacetylases in postembryonic organ transformations in Xenopus laevis. | 2001 | Int. J. Mol. Med. | pmid:11712071 |
Lefevre P et al. | Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element. | 2001 | Nucleic Acids Res. | pmid:11713304 |
Sekita N et al. | Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines. | 2001 | Jpn. J. Cancer Res. | pmid:11572762 |
Yin L et al. | Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity. | 2001 | J. Biol. Chem. | pmid:11572859 |
Leng SL et al. | Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo. | 2001 | Carcinogenesis | pmid:11577001 |
Yang X et al. | Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. | 2001 | Cancer Res. | pmid:11585728 |
Sekimata M et al. | Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. | 2001 | J. Biol. Chem. | pmid:11553631 |
Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
Bovenzi V and Momparler RL | Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells. | 2001 | Cancer Chemother. Pharmacol. | pmid:11488527 |
Franco PJ et al. | The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. | 2001 | Mol. Endocrinol. | pmid:11463856 |
Sutherland JE et al. | The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. | 2001 | Mutat. Res. | pmid:11470494 |
Takakura M et al. | Telomerase activation by histone deacetylase inhibitor in normal cells. | 2001 | Nucleic Acids Res. | pmid:11452025 |
Pujuguet P et al. | Trichostatin A inhibits beta-casein expression in mammary epithelial cells. | 2001 | J. Cell. Biochem. | pmid:11746508 |
Matsusue K et al. | Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. | 2001 | DNA Cell Biol. | pmid:11749719 |
Lavelle D et al. | Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. | 2001 | Am. J. Hematol. | pmid:11754398 |
Lea MA et al. | Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. | 2001 | Int. J. Cancer | pmid:11351296 |
Jordan A et al. | The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. | 2001 | EMBO J. | pmid:11285236 |
Bachl J et al. | Increased transcription levels induce higher mutation rates in a hypermutating cell line. | 2001 | J. Immunol. | pmid:11290786 |
Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
Ding BC et al. | Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. | 2001 | Biochem. Pharmacol. | pmid:11266651 |
Segev H et al. | Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development. | 2001 | Zygote | pmid:11358320 |
Archer SY et al. | p21 gene regulation during enterocyte differentiation. | 2001 | J. Surg. Res. | pmid:11368530 |
Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
Johnson CA et al. | Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. | 2001 | J. Biol. Chem. | pmid:11136718 |
Griswold MD et al. | Mechanisms involved in the homologous down-regulation of transcription of the follicle-stimulating hormone receptor gene in Sertoli cells. | 2001 | Mol. Cell. Endocrinol. | pmid:11223181 |
Chang YC et al. | Cooperation of E2F-p130 and Sp1-pRb complexes in repression of the Chinese hamster dhfr gene. | 2001 | Mol. Cell. Biol. | pmid:11158299 |
Newell-Price J et al. | The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. | 2001 | Mol. Endocrinol. | pmid:11158338 |
Kamitani H et al. | Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. | 2001 | Carcinogenesis | pmid:11159758 |
Rombouts K et al. | Trichostatin A, lead compound for development of antifibrogenic drugs. | 2001 Jul-Sep | Acta Gastroenterol. Belg. | pmid:11680040 |
McGuinness MC et al. | Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. | 2001 Sep-Oct | Mol. Genet. Metab. | pmid:11592822 |
Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
López-Solache I et al. | Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. | 2002 | Endocrine | pmid:12588052 |
Duharcourt S and Yao MC | Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. | 2002 | Eukaryotic Cell | pmid:12455963 |
Strait KA et al. | Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. | 2002 | Mol. Cancer Ther. | pmid:12479699 |
Blagosklonny MV et al. | Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. | 2002 | Mol. Cancer Ther. | pmid:12481415 |
Drewell RA et al. | Methylation-dependent silencing at the H19 imprinting control region by MeCP2. | 2002 | Nucleic Acids Res. | pmid:11861904 |
Murphy JC et al. | Control of cytomegalovirus lytic gene expression by histone acetylation. | 2002 | EMBO J. | pmid:11867539 |
Kim JY et al. | Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. | 2002 | Anal. Chem. | pmid:12433071 |
Gregory RI et al. | Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. | 2002 | J. Biol. Chem. | pmid:11821379 |
Elaut G et al. | Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12433798 |
Lim Y et al. | Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. | 2002 | J. Biol. Chem. | pmid:11821402 |
Yáñez RJ and Porter AC | A chromosomal position effect on gene targeting in human cells. | 2002 | Nucleic Acids Res. | pmid:12433992 |
Wilson MA et al. | The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo. | 2002 | J. Biol. Chem. | pmid:11821430 |
Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
Deroanne CF et al. | Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. | 2002 | Oncogene | pmid:11821955 |
Ego T et al. | The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. | 2002 | Oncogene | pmid:12370815 |
Zhang W and Kone BC | NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12372765 |
Handumrongkul C et al. | Distinct sets of cellular genes control the expression of transfected, nuclear-localized genes. | 2002 | Mol. Ther. | pmid:11829526 |
Ailenberg M and Silverman M | Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379227 |
Herold C et al. | The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. | 2002 | J. Hepatol. | pmid:11830335 |
Yamashita K et al. | Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. | 2002 | Cancer Cell | pmid:12498717 |
Zhou DC et al. | Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. | 2002 | Blood | pmid:11830487 |
Fahrner JA et al. | Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | 2002 | Cancer Res. | pmid:12499261 |
Cabral AL et al. | Regulation of the cellular prion protein gene expression depends on chromatin conformation. | 2002 | J. Biol. Chem. | pmid:11739375 |
Park SH et al. | Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. | 2002 | J. Biol. Chem. | pmid:11744689 |
Suenaga M et al. | Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. | 2002 | Int. J. Cancer | pmid:11807787 |
Gurova KV et al. | Expression of prostate specific antigen (PSA) is negatively regulated by p53. | 2002 | Oncogene | pmid:11791186 |
Maeda Y et al. | Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. | 2002 | Mol. Endocrinol. | pmid:11818510 |
Singal R et al. | Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. | 2002 | J. Biol. Chem. | pmid:11684679 |
Bordonaro M et al. | Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. | 2002 | Int. J. Cancer | pmid:11774242 |
Kikuchi T et al. | Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. | 2002 | Int. J. Cancer | pmid:11774276 |
Rombouts K et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. | 2002 | Exp. Cell Res. | pmid:12169274 |
Waterborg JH and Kapros T | Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. | 2002 | Biochem. Cell Biol. | pmid:12123281 |
Mikkelsen IM et al. | Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. | 2002 | Biochem. Pharmacol. | pmid:12123752 |
Petti MC et al. | Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. | 2002 | Blood | pmid:12130525 |
Gradoville L et al. | Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle. | 2002 | J. Virol. | pmid:11991990 |
Uesato S et al. | Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11992774 |
Nambiar MP et al. | Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling. | 2002 | J. Cell. Biochem. | pmid:11967985 |
Fu M et al. | Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. | 2002 | Mol. Cell. Biol. | pmid:11971970 |
Sirchia SM et al. | Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. | 2002 | Cancer Res. | pmid:11980632 |
Milutinovic S et al. | Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification. | 2002 | J. Biol. Chem. | pmid:11929879 |
Williams RS et al. | A common mechanism of action for three mood-stabilizing drugs. | 2002 | Nature | pmid:12015604 |
Veilleux S and Boissonneault G | Dynamics of reporter gene stimulation by HMG box proteins. | 2002 | DNA Cell Biol. | pmid:12015897 |
Huang HC et al. | Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells. | 2002 | Life Sci. | pmid:12002521 |
Chiocca S et al. | Histone deacetylase 1 inactivation by an adenovirus early gene product. | 2002 | Curr. Biol. | pmid:11937030 |
Curradi M et al. | Molecular mechanisms of gene silencing mediated by DNA methylation. | 2002 | Mol. Cell. Biol. | pmid:11940673 |
Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
Nair RR et al. | Enhancement of transgene expression by combining glucocorticoids and anti-mitotic agents during transient transfection using DNA-cationic liposomes. | 2002 | Mol. Ther. | pmid:11945073 |
Qiu P and Li L | Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression. | 2002 | Circ. Res. | pmid:11988486 |
Mai A et al. | Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. | 2002 | J. Med. Chem. | pmid:11960489 |
Merezak C et al. | Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo. | 2002 | J. Virol. | pmid:11967319 |
Weston AD et al. | Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. | 2002 | J. Cell Biol. | pmid:12105181 |
Lin HM et al. | Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. | 2002 | J. Biol. Chem. | pmid:12048199 |
Quivy V et al. | Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. | 2002 | J. Virol. | pmid:12368351 |
Smith WL and Edlind TD | Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. | 2002 | Antimicrob. Agents Chemother. | pmid:12384361 |
Harada K et al. | Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. | 2002 | Cancer Res. | pmid:12384554 |
Zhang J et al. | Establishment of transcriptional competence in early and late S phase. | 2002 | Nature | pmid:12432398 |
Kostyniuk CL et al. | The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. | 2002 | Oncogene | pmid:12214274 |
Hall IM et al. | Establishment and maintenance of a heterochromatin domain. | 2002 | Science | pmid:12215653 |
Lynch CA et al. | Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. | 2002 | Mol. Cancer | pmid:12234381 |
Bereshchenko OR et al. | Acetylation inactivates the transcriptional repressor BCL6. | 2002 | Nat. Genet. | pmid:12402037 |
Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
Travers H et al. | Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. | 2002 | Exp. Cell Res. | pmid:12413881 |
Wilson AJ et al. | Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. | 2002 | Cancer Res. | pmid:12414619 |
Choy JS and Kron SJ | NuA4 subunit Yng2 function in intra-S-phase DNA damage response. | 2002 | Mol. Cell. Biol. | pmid:12417725 |
Ghoshal K et al. | Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. | 2002 | Mol. Cell. Biol. | pmid:12417732 |
Hauser C et al. | Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. | 2002 | Mol. Cell. Biol. | pmid:12391151 |
Westendorf JJ et al. | Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. | 2002 | Mol. Cell. Biol. | pmid:12391164 |