Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
Vire B et al. | Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions. | 2009 | PLoS ONE | pmid:19759901 |
Lv W et al. | Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. | 2014 | PLoS ONE | pmid:25412078 |
Lu HK et al. | Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. | 2014 | PLoS ONE | pmid:25409334 |
Pichugin A et al. | Ring-like distribution of constitutive heterochromatin in bovine senescent cells. | 2011 | PLoS ONE | pmid:22132080 |
Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
Chandwani S et al. | Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. | 2013 | PLoS ONE | pmid:24204683 |
Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
Smirnova L et al. | MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate. | 2014 | PLoS ONE | pmid:24896083 |
Chang YW and Singh KP | Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells. | 2017 | PLoS ONE | pmid:28323900 |
Li LF et al. | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. | 2017 | PLoS ONE | pmid:28234968 |
Halsall J et al. | Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors. | 2012 | PLoS ONE | pmid:22479401 |
Han B et al. | Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. | 2013 | PLoS ONE | pmid:24312356 |
Morinobu A et al. | Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. | 2016 | PLoS ONE | pmid:27736946 |
Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
Smith S et al. | Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. | 2014 | PLoS ONE | pmid:24466340 |
Andrews KT et al. | Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors. | 2012 | PLoS ONE | pmid:22384084 |
Kondo Y et al. | Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. | 2014 | PLoS ONE | pmid:25084468 |
Agudelo M et al. | Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. | 2016 | PLoS ONE | pmid:27249803 |
Cavalieri V and Spinelli G | Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. | 2015 | PLoS ONE | pmid:26618749 |
Zhang Y et al. | The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. | 2015 | PLoS ONE | pmid:26606052 |
Ignatius MS et al. | Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. | 2013 | PLoS ONE | pmid:23667588 |
Nepelska M et al. | Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. | 2012 | PLoS ONE | pmid:23300800 |
Gupta K et al. | Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. | 2012 | PLoS ONE | pmid:23285096 |
Terhune SS et al. | Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. | 2010 | PLoS Pathog. | pmid:20585571 |
Amor DJ et al. | Human centromere repositioning "in progress". | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084747 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Slack MD et al. | Characterizing heterogeneous cellular responses to perturbations. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19052231 |
Magdinier F and Wolffe AP | Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11309512 |
Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
Porter NJ et al. | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29203661 |
Thompson EM et al. | Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7877974 |
Xu CR et al. | Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16176989 |
Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
Jenster G et al. | Steroid receptor induction of gene transcription: a two-step model. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9223281 |
Bartsch J et al. | Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8855250 |
Kenneth NS et al. | TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17848523 |
Iezzi S et al. | Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032356 |
Richon VM et al. | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501205 |
Ito K et al. | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12070353 |
Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
Selker EU | Trichostatin A causes selective loss of DNA methylation in Neurospora. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689097 |
Liu Z et al. | Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449719 |
Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
Liberatore RA et al. | NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805123 |
McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |