trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chan AS et al. | Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. | 2003 | Oncogene | pmid:14534543 |
| Lu F et al. | Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. | 2003 | J. Virol. | pmid:14557628 |
| Siddiqui H et al. | Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. | 2003 | Mol. Cell. Biol. | pmid:14560017 |
| Martin D et al. | Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines. | 2003 | J. Biol. Chem. | pmid:14565956 |
| Zhang Q et al. | Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. | 2003 | Toxicol. Appl. Pharmacol. | pmid:14575637 |
| Usenko T et al. | Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. | 2003 | Oncogene | pmid:14576829 |
| Allison SJ and Milner J | Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. | 2003 | Cancer Res. | pmid:14583461 |
| Chaturvedi V et al. | Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. | 2004 | J. Cell. Physiol. | pmid:14584049 |
| Mai A et al. | Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. | 2003 | J. Med. Chem. | pmid:14584932 |
| Pace BS et al. | p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. | 2003 | Exp. Hematol. | pmid:14585374 |
| Shteper PJ et al. | Role of promoter methylation in regulation of the mammalian heparanase gene. | 2003 | Oncogene | pmid:14586400 |
| Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
| Vasudevan A et al. | Heterocyclic ketones as inhibitors of histone deacetylase. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592473 |
| Chung YL et al. | A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. | 2003 | Mol. Ther. | pmid:14599803 |
| Liu A et al. | Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. | 2003 | Glia | pmid:14603467 |
| Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
| Kim MS et al. | Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. | 2003 | Cancer Res. | pmid:14612526 |
| Miller TA et al. | Histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14613312 |
| Hitomi T et al. | p15(INK4b) in HDAC inhibitor-induced growth arrest. | 2003 | FEBS Lett. | pmid:14623092 |
| Hejnar J et al. | Demethylation of host-cell DNA at the site of avian retrovirus integration. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14623319 |
| Kramps C et al. | E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. | 2004 | J. Biol. Chem. | pmid:14645238 |
| Wong JE et al. | Therapeutic strategies in gastric cancer. | 2003 | J. Clin. Oncol. | pmid:14645406 |
| Suzuki M et al. | Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression. | 2003 | Oncogene | pmid:14647463 |
| Kim HS et al. | Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14651963 |
| Coombes MM et al. | Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. | 2003 | Oncogene | pmid:14654786 |
| Thelen P et al. | Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. | 2004 | Int. J. Oncol. | pmid:14654937 |
| Shim JS et al. | Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. | 2004 | Oncogene | pmid:14661058 |
| Kim DK et al. | Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14667227 |
| Brush MH et al. | Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. | 2004 | J. Biol. Chem. | pmid:14670976 |
| Jang ER et al. | The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. | 2004 | Oncogene | pmid:14676837 |
| Vaisburg A et al. | (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14684344 |
| Nambu Y et al. | Transcription-coupled events associating with immunoglobulin switch region chromatin. | 2003 | Science | pmid:14684824 |
| Obata T et al. | Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. | 2003 | Clin. Cancer Res. | pmid:14695142 |
| Terui T et al. | Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. | 2003 | Cancer Res. | pmid:14695212 |
| Leu TH et al. | Participation of p97Eps8 in Src-mediated transformation. | 2004 | J. Biol. Chem. | pmid:14699156 |
| Haggarty SJ et al. | Small molecule modulation of the human chromatid decatenation checkpoint. | 2003 | Chem. Biol. | pmid:14700634 |
| Pagans S et al. | Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. | 2004 | J. Biol. Chem. | pmid:14701830 |
| Yan C et al. | A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. | 2004 | FASEB J. | pmid:14715692 |
| Sugimoto S et al. | Expression and regulation of tumor suppressor gene maspin in human bladder cancer. | 2004 | Cancer Lett. | pmid:14732229 |
| Christian M et al. | Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. | 2004 | J. Biol. Chem. | pmid:14736873 |
| Nishikawa J et al. | Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line. | 2004 | Virus Genes | pmid:14739656 |
| Wang DF et al. | QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741273 |
| Parekh-Olmedo H et al. | The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. | 2003 | Ann. N. Y. Acad. Sci. | pmid:14751821 |
| Lee JH et al. | Histone deacetylase activity is required for embryonic stem cell differentiation. | 2004 | Genesis | pmid:14755802 |
| Lemonde S et al. | Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. | 2004 | J. Neurochem. | pmid:14756806 |
| Hattori N et al. | Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. | 2004 | J. Biol. Chem. | pmid:14761969 |
| Um SJ et al. | In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group. | 2004 | Oncol. Rep. | pmid:14767528 |
| GarcÃa I et al. | Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. | 2004 | Eukaryotic Cell | pmid:14871945 |
| Takai N et al. | Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. | 2004 | Clin. Cancer Res. | pmid:14871994 |
| Reifenberger J et al. | Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. | 2004 | Int. J. Cancer | pmid:14961576 |