Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Majumder S et al. | Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. | 2006 | J. Cell. Biochem. | pmid:16329111 |
Kurschat P et al. | Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. | 2006 | J. Biol. Chem. | pmid:16330548 |
Suzuki M et al. | Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. | 2006 | Oncogene | pmid:16331260 |
Fan J et al. | [Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17533736 |
de Boer J et al. | Inhibition of histone acetylation as a tool in bone tissue engineering. | 2006 | Tissue Eng. | pmid:17518660 |
Malone CS et al. | B29 gene silencing in pituitary cells is regulated by its 3' enhancer. | 2006 | J. Mol. Biol. | pmid:16920149 |
Herman D et al. | Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. | 2006 | Nat. Chem. Biol. | pmid:16921367 |
Takahashi K et al. | Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. | 2006 | Int. J. Oncol. | pmid:16391785 |
Topark-Ngarm A et al. | CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. | 2006 | J. Biol. Chem. | pmid:16950772 |
Bai T et al. | A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. | 2006 | Int. J. Oncol. | pmid:16391806 |
Li Y et al. | A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. | 2006 | Genes Dev. | pmid:16980585 |
Pazmany T and Tomasi TB | The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. | 2006 | J. Neuroimmunol. | pmid:16360884 |
Minetti GC et al. | Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. | 2006 | Nat. Med. | pmid:16980968 |
Lee KY et al. | NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. | 2006 | J. Immunol. | pmid:16365456 |
Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
Dowdy SC et al. | Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. | 2006 | Mol. Cancer Ther. | pmid:17121923 |
Saunders LR and Verdin E | Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:17121924 |
Yang QC et al. | Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. | 2006 | J. Exp. Clin. Cancer Res. | pmid:17310851 |
D'Andrea M et al. | Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. | 2006 | J. Cell. Physiol. | pmid:16419034 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
Uchida H et al. | Human endometrial cytodifferentiation by histone deacetylase inhibitors. | 2006 | Hum. Cell | pmid:16643606 |
Stefanovsky V and Moss T | Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count. | 2006 | Cell Cycle | pmid:16582637 |
Wang Q et al. | Histone deacetylation is required for orderly meiosis. | 2006 | Cell Cycle | pmid:16582639 |
Magnaghi-Jaulin L and Jaulin C | Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis. | 2006 | Chromosome Res. | pmid:16628502 |
Pavan Kumar P et al. | Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. | 2006 | Mol. Cell | pmid:16630892 |
Vinken M et al. | Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. | 2006 | Toxicol. Sci. | pmid:16531468 |
Gastaldi T et al. | Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. | 2006 | Carcinogenesis | pmid:16537559 |
Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
Wu Y and Guo SW | Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. | 2006 | Gynecol. Obstet. Invest. | pmid:16778450 |
Iacomino G et al. | Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line. | 2006 | J. Cell. Biochem. | pmid:16795040 |
Vanniasinkam T et al. | Trichostatin-A enhances adaptive immune responses to DNA vaccination. | 2006 | J. Clin. Virol. | pmid:16765083 |
Li GC et al. | Histone deacetylase inhibitor trichostatin A inhibits the growth of bladder cancer cells through induction of p21WAF1 and G1 cell cycle arrest. | 2006 | Int. J. Urol. | pmid:16771729 |
Zhou C et al. | Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. | 2006 | Int. J. Oncol. | pmid:16773209 |
Zampetaki A et al. | TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16814255 |
Jüngel A et al. | Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis. | 2006 | Ann. Rheum. Dis. | pmid:16284094 |
Nygård M et al. | Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. | 2006 | J. Mol. Endocrinol. | pmid:16720720 |
Armstrong K et al. | NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. | 2006 | Prostate | pmid:16683270 |
Wischnewski F et al. | Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. | 2006 | Mol. Cancer Res. | pmid:16687489 |
Yamada N et al. | MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. | 2006 | Int. J. Cancer | pmid:16721789 |
Sestáková B and Vachtenheim J | Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter. | 2006 | Folia Biol. (Praha) | pmid:17116288 |
Balasubramaniyan V et al. | Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. | 2006 | Neuroscience | pmid:17084985 |
Zhang Y et al. | Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. | 2006 | Mol. Cell. Biol. | pmid:16943418 |
Stewart MD et al. | Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange. | 2006 | Mol. Cell. Biol. | pmid:16943430 |
El-Zawahry A et al. | In vitro efficacy of AdTRAIL gene therapy of bladder cancer is enhanced by trichostatin A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL. | 2006 | Cancer Gene Ther. | pmid:16167063 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Mühlisch J et al. | Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. | 2006 | Oncogene | pmid:16186793 |
Hirsch CL et al. | Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. | 2006 | Int. J. Cancer | pmid:16094635 |
Kozłowska A and Jagodziński PP | Effect of Trichostatin A on CD4 surface density in peripheral blood T cells. | 2006 | Folia Histochem. Cytobiol. | pmid:17219719 |
He J et al. | Effects of trichostatin A on HDAC8 expression, proliferation and cell cycle of Molt-4 cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219959 |
Liu H et al. | Trichostatin A regulates hGCN5 expression and cell cycle on Daudi cells in vitro. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219960 |
Sun C et al. | Anticancer activities of trichostatin A on maligant lymphoid cells. | 2006 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:17219961 |
Kim HR et al. | Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway? | 2006 | Exp. Mol. Med. | pmid:17202837 |
Karvonen U et al. | Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. | 2006 | Exp. Cell Res. | pmid:16860317 |
Wagner S et al. | SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1. | 2006 | J. Biol. Chem. | pmid:16861234 |
Zhang X et al. | Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines. | 2006 | Oncol. Rep. | pmid:16865256 |
Villanueva R et al. | Histone deacetylase 3 represses HTLV-1 tax transcription. | 2006 | Oncol. Rep. | pmid:16865259 |
van den Boom J et al. | Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. | 2006 | Int. J. Cancer | pmid:16865689 |
Bai J et al. | Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904634 |
Charrier C et al. | Synthesis of rigid trichostatin A analogs as HDAC inhibitors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16904890 |
Okamoto H et al. | Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). | 2006 | J. Atheroscler. Thromb. | pmid:16908950 |
Claus R et al. | Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. | 2006 | J. Leukoc. Biol. | pmid:17000900 |
Kogai T et al. | Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. | 2006 | Endocr. Relat. Cancer | pmid:16954431 |
Ostapkowicz A et al. | Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. | 2006 | Mol. Cancer Ther. | pmid:16505096 |
Hellebrekers DM et al. | Angiostatic activity of DNA methyltransferase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:16505122 |
Seo H et al. | An ex vivo method for rapid generation of monoclonal antibodies (ADLib system). | 2006 | Nat Protoc | pmid:17406441 |
Kong X et al. | Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. | 2006 | Mol. Cell. Biol. | pmid:16507982 |
Araki H et al. | Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. | 2006 | Exp. Hematol. | pmid:16459182 |
Sonnemann J et al. | Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. | 2006 | Int. J. Oncol. | pmid:16465382 |
Pedram M et al. | Telomere position effect and silencing of transgenes near telomeres in the mouse. | 2006 | Mol. Cell. Biol. | pmid:16479005 |
Rybouchkin A et al. | Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. | 2006 | Biol. Reprod. | pmid:16481594 |
Banchio C et al. | Role of histone deacetylase in the expression of CTP:phosphocholine cytidylyltransferase alpha. | 2006 | J. Biol. Chem. | pmid:16484221 |
Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |
Fandy TE and Srivastava RK | Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. | 2006 | Cancer Chemother. Pharmacol. | pmid:16435155 |
Deng G et al. | Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. | 2006 | Int. J. Cancer | pmid:16425274 |
Kwon HS et al. | Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. | 2006 Mar-Apr | Biochim. Biophys. Acta | pmid:16757381 |
Bai L and Merchant JL | ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560543 |
Rigamonti D et al. | Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators. | 2007 | J. Biol. Chem. | pmid:17565993 |
Huang JC et al. | Changes in histone acetylation during postovulatory aging of mouse oocyte. | 2007 | Biol. Reprod. | pmid:17582009 |
Fang S et al. | Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. | 2007 | Mol. Cell. Biol. | pmid:17145766 |
Kato N et al. | Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. | 2007 | Leukemia | pmid:17625602 |
Bu Y and Gelman IH | v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. | 2007 | J. Biol. Chem. | pmid:17626016 |
Dombrowsky H and Uhlig S | Steroids and histone deacetylase in ventilation-induced gene transcription. | 2007 | Eur. Respir. J. | pmid:17626110 |
Gahr S et al. | The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells. | 2007 | Int. J. Oncol. | pmid:17671683 |
Tomita A et al. | Epigenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with rituximab-containing chemotherapy. | 2007 | Int. J. Hematol. | pmid:17675267 |
Wang J et al. | Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. | 2007 | J. Biol. Chem. | pmid:17675290 |
Ishihara K et al. | Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors. | 2007 | Life Sci. | pmid:17258775 |
Putignano E et al. | Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. | 2007 | Neuron | pmid:17329213 |
Vibhakar R et al. | Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. | 2007 | Neuro-oncology | pmid:17329407 |
Robertson DM et al. | Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium. | 2007 | Exp. Eye Res. | pmid:17709104 |
Chen WY et al. | Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1). | 2007 | Mol. Cell. Biol. | pmid:17709382 |
Markova NG et al. | Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin. | 2007 | J. Invest. Dermatol. | pmid:17195011 |
Fujita Y et al. | Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. | 2007 | Dev. Cell | pmid:17199038 |
Kovács P et al. | Effect of histone deacetylase inhibitor trichostatin A (TSA) on the microtubular system of Tetrahymena. | 2007 | Acta. Biol. Hung. | pmid:18277464 |
Akao Y et al. | Downregulation of microRNAs-143 and -145 in B-cell malignancies. | 2007 | Cancer Sci. | pmid:17892514 |
Murga M et al. | Global chromatin compaction limits the strength of the DNA damage response. | 2007 | J. Cell Biol. | pmid:17893239 |
Schnur N et al. | The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. | 2007 | Biochim. Biophys. Acta | pmid:17894944 |
Oshima M et al. | Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17949687 |
Scott SA et al. | Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression. | 2007 | Exp. Hematol. | pmid:17258075 |
Hummel M et al. | Transcriptional reactivation of murine cytomegalovirus ie gene expression by 5-aza-2'-deoxycytidine and trichostatin A in latently infected cells despite lack of methylation of the major immediate-early promoter. | 2007 | J. Gen. Virol. | pmid:17374752 |