trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang Z et al. | Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. | 2013 | Plant Cell | pmid:23371947 |
| Horvat T et al. | Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. | 2013 | PLoS ONE | pmid:23336012 |
| Li H et al. | Epigenetic regulation of CXCR4 expression by the ocular microenvironment. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23188729 |
| Gill RK et al. | Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23195070 |
| Wessels I et al. | Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis. | 2013 | Immunobiology | pmid:23195574 |
| Wunder T et al. | Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection. | 2013 | Cancer Gene Ther. | pmid:23196273 |
| Oliveira CS et al. | HDAC inhibition decreases XIST expression on female IVP bovine blastocysts. | 2013 | Reproduction | pmid:23104973 |
| Kuno A et al. | Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein. | 2013 | J. Biol. Chem. | pmid:23297412 |
| Luo Y et al. | High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy. | 2013 | Eur. J. Cancer | pmid:23040637 |
| Zhang C et al. | Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure. | 2013 | Cell Biochem. Biophys. | pmid:22907585 |
| Liu Y et al. | MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. | 2013 | Toxicol. Lett. | pmid:23770000 |
| Welch MD et al. | Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia. | 2013 | Br. J. Haematol. | pmid:23772794 |
| Aseem O et al. | Cubilin expression is monoallelic and epigenetically augmented via PPARs. | 2013 | BMC Genomics | pmid:23773363 |
| Wang H et al. | Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. | 2013 | Nat. Neurosci. | pmid:23727821 |
| Gao B et al. | Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. | 2013 | J. Immunol. | pmid:23729439 |
| Luo B et al. | A possible strategy to produce pigs resistant to porcine reproductive and respiratory syndrome virus. | 2013 | Antiviral Res. | pmid:23732571 |
| Spallotta F et al. | A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. | 2013 | J. Biol. Chem. | pmid:23463510 |
| Wu DS et al. | Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. | 2013 | Oncol. Rep. | pmid:24064951 |
| Al-Nakhle H et al. | Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. | 2013 | Int. J. Oncol. | pmid:24068253 |
| Yu CW et al. | Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. | 2013 | J. Med. Chem. | pmid:23905680 |
| Chikamatsu K et al. | Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck. | 2013 | Cancer Sci. | pmid:23992541 |
| Oksenych V et al. | Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack. | 2013 | PLoS Genet. | pmid:23861670 |
| BurlibaÅŸa L and Zarnescu O | In vivo effects of Trichostatin A - A histone deacetylase inhibitor - On chromatin remodeling during Triturus cristatus spermatogenesis. | 2013 | Anim. Reprod. Sci. | pmid:24100069 |
| Contreras AU et al. | Deacetylation of p53 induces autophagy by suppressing Bmf expression. | 2013 | J. Cell Biol. | pmid:23629966 |
| Duo J et al. | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | 2013 | DNA Cell Biol. | pmid:23451817 |
| Chen CQ et al. | Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. | 2013 | Carcinogenesis | pmid:23430957 |
| Choi S et al. | Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23665318 |
| Wang YJ et al. | Histone acetylation in the olfactory bulb of young rats facilitates aversive olfactory learning and synaptic plasticity. | 2013 | Neuroscience | pmid:23262233 |
| Diao JS et al. | Histone deacetylase inhibitor reduces hypertrophic scarring in a rabbit ear model. | 2013 | Plast. Reconstr. Surg. | pmid:23806955 |
| Oliveira CS et al. | Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos. | 2013 | Zygote | pmid:21867598 |
| Wang P et al. | Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. | 2013 | Neurotoxicology | pmid:23558232 |
| Joosten M et al. | Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype. | 2013 | Haematologica | pmid:22899583 |
| Krause M et al. | Probing the compressibility of tumor cell nuclei by combined atomic force-confocal microscopy. | 2013 | Phys Biol | pmid:24304807 |
| Frame FM et al. | HDAC inhibitor confers radiosensitivity to prostate stem-like cells. | 2013 | Br. J. Cancer | pmid:24220693 |
| Jagirdar K et al. | The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. | 2013 | PLoS ONE | pmid:24223135 |
| Keuser B et al. | Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. | 2013 | Mutagenesis | pmid:23814181 |
| Lim SY et al. | Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. | 2013 | Stem Cells Transl Med | pmid:23884641 |
| Asthana J et al. | Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. | 2013 | J. Biol. Chem. | pmid:23798680 |
| Gundersen B | Pair-bonding through epigenetics. | 2013 | Nat. Neurosci. | pmid:23799469 |
| Feng T et al. | Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2). | 2013 | Bioorg. Med. Chem. | pmid:23820574 |
| Lopez-Atalaya JP et al. | Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. | 2013 | Nucleic Acids Res. | pmid:23821663 |
| Okada T et al. | Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas. | 2013 | Cancer Sci. | pmid:23829175 |
| Marek L et al. | Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. | 2013 | J. Med. Chem. | pmid:23252603 |
| Li KK et al. | MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. | 2013 | Brain Pathol. | pmid:23252729 |
| Seuter S et al. | The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23220548 |
| Singh T et al. | Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. | 2013 | Epigenetics | pmid:23221619 |
| Montero-Melendez T et al. | Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors. | 2013 | Cell Death Differ. | pmid:23222458 |
| McBrian MA et al. | Histone acetylation regulates intracellular pH. | 2013 | Mol. Cell | pmid:23201122 |
| Shi H et al. | Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23201405 |
| Tavakoli-Yaraki M et al. | Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. | 2013 | Tumour Biol. | pmid:23055198 |