Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kawano T et al. | Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect. | 2004 Sep-Oct | Anticancer Res. | pmid:15517875 |
Fenic I et al. | In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. | 2004 Sep-Oct | J. Androl. | pmid:15292114 |
Kook SH et al. | Epstein-Barr virus-infected Akata cells are sensitive to histone deacetylase inhibitor TSA-provoked apoptosis. | 2005 | J. Biochem. Mol. Biol. | pmid:16336792 |
Chen LJ et al. | [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403252 |
Kasper LH et al. | Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. | 2005 | EMBO J. | pmid:16237459 |
Columbaro M et al. | Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. | 2005 | Cell. Mol. Life Sci. | pmid:16261260 |
Burlibaşa L and Gavrilă L | Molecular and ultrastructural studies of the sperm chromatin from Triturus cristatus. | 2005 | Zygote | pmid:16261764 |
Marengo E et al. | Use of Legendre moments for the fast comparison of two-dimensional polyacrylamide gel electrophoresis maps images. | 2005 | J Chromatogr A | pmid:16301071 |
Juranek SA et al. | snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates. | 2005 | Eukaryotic Cell | pmid:16278460 |
Chang CW et al. | Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. | 2005 | Mol. Cell. Biol. | pmid:16166624 |
Jori FP et al. | RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. | 2005 | Cell Death Differ. | pmid:15459751 |
Johnson J et al. | Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid. | 2005 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:16171558 |
Karagiannis TC et al. | The histone deacetylase inhibitor, Trichostatin A, enhances radiation sensitivity and accumulation of gammaH2A.X. | 2005 | Cancer Biol. Ther. | pmid:16082178 |
Xiong Y et al. | Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. | 2005 | Gynecol. Oncol. | pmid:16024066 |
Xu CR et al. | Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16176989 |
Wu P et al. | Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16051188 |
Yaneva M et al. | Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. | 2005 | Nucleic Acids Res. | pmid:16177181 |
Kang JE et al. | Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1. | 2005 | Cell. Physiol. Biochem. | pmid:16121030 |
Chen CS et al. | Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. | 2005 | J. Biol. Chem. | pmid:16186112 |
Bradbury CA et al. | Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. | 2005 | Leukemia | pmid:16121216 |
Cismasiu VB et al. | BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. | 2005 | Oncogene | pmid:16091750 |
Fang MZ et al. | Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. | 2005 | Clin. Cancer Res. | pmid:16203797 |
GarcÃa-Morales P et al. | Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. | 2005 | Mol. Cancer Ther. | pmid:16093438 |
Menegola E et al. | Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity. | 2005 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:16193500 |
Nome RV et al. | Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death. | 2005 | Mol. Cancer Ther. | pmid:16093439 |
Liu AL et al. | [A new target of cancer therapy: advances in the study of histone deacetylase]. | 2005 | Yao Xue Xue Bao | pmid:16196262 |
Gurvich N et al. | Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. | 2005 | FASEB J. | pmid:15901671 |
Gan Y et al. | Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. | 2005 | J. Biol. Chem. | pmid:15722551 |
Endo M et al. | Novel gender-related regulation of CYP2C12 gene expression in rats. | 2005 | Mol. Endocrinol. | pmid:15661834 |
Sengupta S et al. | Tumor suppressor p53 represses transcription of RECQ4 helicase. | 2005 | Oncogene | pmid:15674334 |
Busson M et al. | Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. | 2005 | Oncogene | pmid:15674337 |
Wen J et al. | Tal1/SCL binding to pericentromeric DNA represses transcription. | 2005 | J. Biol. Chem. | pmid:15677454 |
Illi B et al. | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. | 2005 | Circ. Res. | pmid:15705964 |
Law RD and Suttle JC | Chromatin remodeling in plant cell culture: patterns of DNA methylation and histone H3 and H4 acetylation vary during growth of asynchronous potato cell suspensions. | 2005 | Plant Physiol. Biochem. | pmid:15922608 |
Seo H et al. | Rapid generation of specific antibodies by enhanced homologous recombination. | 2005 | Nat. Biotechnol. | pmid:15924134 |
Song Y et al. | [The mechanisms of p21WAF1/Cip-1 expression in MOLT-4 cell line induced by TSA]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854272 |
Xu ZM et al. | [Analysis of the methylation in the promoter of LRP15 gene and its expression]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854274 |
Mai A et al. | Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. | 2005 | J. Med. Chem. | pmid:15857140 |
Ho WC et al. | Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. | 2005 | Cancer Res. | pmid:15899819 |
Tran T et al. | Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. | 2005 | Cancer Res. | pmid:15899836 |
Camelo S et al. | Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. | 2005 | J. Neuroimmunol. | pmid:15885809 |
Young DA et al. | Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. | 2005 | FEBS J. | pmid:15819885 |
Canes D et al. | Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. | 2005 | Int. J. Cancer | pmid:15499627 |
Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |
Dote H et al. | Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. | 2005 | Br. J. Cancer | pmid:15770214 |
Laberge RM and Boissonneault G | On the nature and origin of DNA strand breaks in elongating spermatids. | 2005 | Biol. Reprod. | pmid:15772260 |
McKenzie GJ et al. | Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. | 2005 | J. Neurochem. | pmid:15773917 |
Blais M et al. | Synergy between deacetylase inhibitors and IL-1beta in activation of the serum amyloid A2 gene promoter. | 2005 | DNA Cell Biol. | pmid:15812237 |