Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li M et al. | Upregulation of human with-no-lysine kinase-4 gene expression by GATA-1 acetylation. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18793746 |
Patel V et al. | Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. | 2009 | J. Med. Chem. | pmid:19317450 |
GarcÃa-Villegas R et al. | Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a). | 2009 | J. Neurosci. Res. | pmid:19326446 |
Seo J et al. | Differential expression of stromal cell-derived factor 1 in human brain microvascular endothelial cells and pericytes involves histone modifications. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19289100 |
Cecconi D et al. | Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. | 2009 | Proteomics | pmid:19294695 |
Ikeda S et al. | Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. | 2009 | Zygote | pmid:19356267 |
Morita K et al. | Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. | 2009 | J. Neurosci. Res. | pmid:19360904 |
von Burstin J et al. | E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. | 2009 | Gastroenterology | pmid:19362090 |
Yang X et al. | CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. | 2009 | PLoS ONE | pmid:19340297 |
Slattery EL et al. | Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. | 2009 | J. Assoc. Res. Otolaryngol. | pmid:19340485 |
Vilar E et al. | Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. | 2009 | Clin. Cancer Res. | pmid:19351759 |
Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
Kee HJ and Kook H | Krüppel-like factor 4 mediates histone deacetylase inhibitor-induced prevention of cardiac hypertrophy. | 2009 | J. Mol. Cell. Cardiol. | pmid:19729022 |
Ong DC et al. | LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. | 2009 | Oncogene | pmid:19734946 |
Alao JP et al. | Inhibition of type I histone deacetylase increases resistance of checkpoint-deficient cells to genotoxic agents through mitotic delay. | 2009 | Mol. Cancer Ther. | pmid:19723888 |
Bennett KL et al. | AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma. | 2009 | PLoS ONE | pmid:19742317 |
Meng CF et al. | [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. | 2009 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:19742343 |
Dombrowsky H et al. | Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. | 2009 | Pulm Pharmacol Ther | pmid:19744573 |
Dandrea M et al. | MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines. | 2009 | Nucleic Acids Res. | pmid:19745053 |
Lugrin J et al. | Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation. | 2009 | Biochim. Biophys. Acta | pmid:19747950 |
Cervera RP et al. | Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos. | 2009 | Theriogenology | pmid:19765811 |
Diplas AI et al. | Demonstration of all-or-none loss of imprinting in mRNA expression in single cells. | 2009 | Nucleic Acids Res. | pmid:19767614 |
Ma XX et al. | Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. | 2009 | Eur. J. Gynaecol. Oncol. | pmid:19697617 |
Chen FQ et al. | Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea. | 2009 | J. Neurochem. | pmid:19141081 |
Zhao W et al. | Histone deacetylase inhibitor, trichostatin A, affects gene expression patterns during morphogenesis of chicken limb buds in vivo. | 2009 | Cells Tissues Organs (Print) | pmid:19147985 |
Giustiniani J et al. | Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53. | 2009 | Cell. Signal. | pmid:19136058 |
Chen Y et al. | 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. | 2009 | Eur J Med Chem | pmid:19136179 |
Cowell RM et al. | Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19118529 |
Wiesen JL and Tomasi TB | Dicer is regulated by cellular stresses and interferons. | 2009 | Mol. Immunol. | pmid:19118902 |
Togi S et al. | HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19121623 |
Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
Trunzer M et al. | Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation. | 2009 | J. Med. Chem. | pmid:19108654 |
Smil DV et al. | Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19111466 |
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Hambach L et al. | Hypomethylating drugs convert HA-1-negative solid tumors into targets for stem cell-based immunotherapy. | 2009 | Blood | pmid:19096014 |
Mavis CK et al. | Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. | 2009 | Prostate | pmid:19444856 |
Samuni Y et al. | The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation. | 2009 | Free Radic. Biol. Med. | pmid:19447172 |
Gavin DP et al. | Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. | 2009 | J Psychiatry Neurosci | pmid:19448855 |
Astrand C et al. | Histone acetylation characterizes chromatin presetting by NF1 and Oct1 and enhances glucocorticoid receptor binding to the MMTV promoter. | 2009 | Exp. Cell Res. | pmid:19463811 |
Riester D et al. | Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19457659 |
Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
Woodfield GW et al. | Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. | 2009 | Clin. Cancer Res. | pmid:19458056 |
Hauswald S et al. | Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes. | 2009 | Clin. Cancer Res. | pmid:19458058 |
Sawarkar R et al. | Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. | 2009 | J. Mol. Biol. | pmid:19576222 |
Hsu PY et al. | Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. | 2009 | Cancer Res. | pmid:19549897 |
Noh H et al. | Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19553350 |
Jonsen MD et al. | The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. | 2009 | Mol. Endocrinol. | pmid:19556346 |
Link PA et al. | Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. | 2009 | Mol. Cancer Res. | pmid:19531572 |
Chen IH et al. | Cytotoxic triterpenoids from the stems of Microtropis japonica. | 2009 | J. Nat. Prod. | pmid:19534471 |
Casero RA and Woster PM | Recent advances in the development of polyamine analogues as antitumor agents. | 2009 | J. Med. Chem. | pmid:19534534 |
Dubois F et al. | Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. | 2009 | Mol. Biochem. Parasitol. | pmid:19538992 |
Ma XL et al. | [Construction of anti-sense cDNA library of human breast cancer cells during apoptosis induced by trichostatin A and preliminary screening of essential genes]. | 2009 | Zhonghua Yi Xue Za Zhi | pmid:19567099 |
Moon C et al. | Use of epigenetic modification to induce FOXP3 expression in naïve T cells. | 2009 | Transplant. Proc. | pmid:19545742 |
Thiel A et al. | 15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. | 2009 | Clin. Cancer Res. | pmid:19584167 |
Rahim R and Strobl JS | Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. | 2009 | Anticancer Drugs | pmid:19584707 |
Nadasi E et al. | Epigenetic modifiers exacerbate oxidative stress in renal proximal tubule cells. | 2009 | Anticancer Res. | pmid:19528494 |
Piotrowska H and Jagodzinski PP | Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells. | 2009 | Arch. Med. Res. | pmid:19427965 |
López-Soto A et al. | HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer. | 2009 | Oncogene | pmid:19430493 |
Kim W et al. | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis. | 2009 | Cell Res. | pmid:19436261 |
Yoshida M | Chemical genomics: a key to the epigenome - an interview with Minoru Yoshida. Interview by Saadi Khochbin. | 2009 | Int. J. Dev. Biol. | pmid:19412886 |
Han DW et al. | Epigenetic hierarchy governing Nestin expression. | 2009 | Stem Cells | pmid:19415779 |
Derks S et al. | Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. | 2009 | Carcinogenesis | pmid:19329758 |
Liu X et al. | The improvement of adenovirus vector production by increased expression of coxsackie adenovirus receptor. | 2009 | Biotechnol. Lett. | pmid:19330491 |
Hollosi P et al. | Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells. | 2009 | Int. J. Cancer | pmid:19330836 |
Chen J et al. | E1A has no effect on LPS-induced IL-6 secretion in rat alveolar epithelial cells. | 2009 | Respiration | pmid:19299891 |
Shao GB et al. | Effect of trychostatin A treatment on gene expression in cloned mouse embryos. | 2009 | Theriogenology | pmid:19246084 |
Cunneen TS et al. | In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells. | 2009 | Arch. Ophthalmol. | pmid:19365017 |
Charrier C et al. | Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression. | 2009 | J. Med. Chem. | pmid:19385600 |
Yap OW et al. | Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells. | 2009 | Anticancer Res. | pmid:19331143 |
Åuczak MW and JagodziÅ„ski PP | Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells. | 2009 | Biomed. Pharmacother. | pmid:18602794 |
Kusakabe M et al. | Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19878646 |
Ma X et al. | Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach. | 2009 | Mol. Cancer Ther. | pmid:19887557 |
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Röhrs S et al. | Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. | 2009 | Mol. Cancer | pmid:19835597 |
Wang Y et al. | HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells. | 2009 | Neurosci. Lett. | pmid:19835929 |
Mastitskaya S and Denecke B | Human spongiosa mesenchymal stem cells fail to generate cardiomyocytes in vitro. | 2009 | J Negat Results Biomed | pmid:19903342 |
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O'Leary DA et al. | Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. | 2009 | PLoS ONE | pmid:20020055 |
Halaban R et al. | Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. | 2009 | PLoS ONE | pmid:19234609 |
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Sakurai T et al. | Induction of endogenous interferon tau gene transcription by CDX2 and high acetylation in bovine nontrophoblast cells. | 2009 | Biol. Reprod. | pmid:19211809 |
Chakravorty M et al. | IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. | 2009 | Int. J. Biochem. Cell Biol. | pmid:19166966 |
Zhang D et al. | [Synergistic cytotoxicity effect of histone deacetylase inhibitor combined with paclitaxel on lung cancer cell lines and its mechanism]. | 2009 | Ai Zheng | pmid:19958621 |
Sharma A et al. | Trichostatin a inhibits corneal haze in vitro and in vivo. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19168895 |
Li X et al. | Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. | 2009 | Blood | pmid:19864643 |
Zubia A et al. | Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. | 2009 | Oncogene | pmid:19169274 |
Meng Q et al. | Live birth of somatic cell-cloned rabbits following trichostatin A treatment and cotransfer of parthenogenetic embryos. | 2009 | Cloning Stem Cells | pmid:19196041 |
Gray SG et al. | Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. | 2009 | Eur. J. Cancer | pmid:19818596 |
Zhang F et al. | Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. | 2009 | Cancer Biol. Ther. | pmid:19270532 |
Hara D et al. | Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19818730 |
Tan HH and Porter AG | p21(WAF1) negatively regulates DNMT1 expression in mammalian cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19275888 |
Li C et al. | Induction of myelogenous leukemia cells with histone deacetylase inhibitors through down-regulating the Daxx protein expression. | 2009 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:19821084 |
Gavin DP et al. | Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. | 2009 | J Psychiatr Res | pmid:19187942 |
Liberatore RA et al. | NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805123 |
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Gibbs A et al. | Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805354 |
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Lee JH et al. | Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway. | 2009 | Mol. Cancer Res. | pmid:19808903 |
Allritz C et al. | Endothelin-1 reverses the histone deacetylase inhibitor-induced increase in glial glutamate transporter transcription without affecting histone acetylation levels. | 2009 Jul-Aug | Neurochem. Int. | pmid:19428803 |