Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Takamatsu G et al. | Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27939885 |
Aquea F et al. | Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27993678 |
Good KV et al. | Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. | 2017 | Epigenetics | pmid:29099289 |
Duan H et al. | The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. | 2017 | Placenta | pmid:28012453 |
Mengel A et al. | Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases. | 2017 | Plant Physiol. | pmid:27980017 |
Jia L et al. | Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. | 2017 | Oncol. Rep. | pmid:27878285 |
Lin W et al. | Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. | 2017 | Kidney Int. | pmid:28416226 |
Simões-Pires CA et al. | Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. | 2017 | J Vis Exp | pmid:28829415 |
Ngwa CJ et al. | Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite . | 2017 | Front Cell Infect Microbiol | pmid:28791254 |
Wang SC et al. | Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. | 2017 | Oncol. Rep. | pmid:28713892 |
Pérez-Garrastachu M et al. | Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. | 2017 | Nucleus | pmid:28696859 |
Ma T et al. | Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. | 2017 | Cell Death Dis | pmid:29072686 |
Androutsopoulos VP and Spandidos DA | Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. | 2017 | Oncol. Rep. | pmid:29039546 |
Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
Lim SY et al. | Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. | 2016 | Methods Mol. Biol. | pmid:25520285 |
Dai Q et al. | Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. | 2016 | Acta Pharmacol. Sin. | pmid:26775659 |
Shao A et al. | Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. | 2016 | Mol. Neurobiol. | pmid:25399954 |
Rong X et al. | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 2016 | Sci Rep | pmid:27703255 |
Li X et al. | Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27396813 |
Robert C et al. | Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. | 2016 | Leuk. Res. | pmid:27064363 |
Mohammadi-Bardbori A et al. | Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling. | 2016 | Chem. Biol. Interact. | pmid:27041069 |
Zhang Y and Zhang B | Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26509796 |
Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
DÃaz-Núñez M et al. | Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. | 2016 | BMC Cancer | pmid:27549189 |
Bricambert J et al. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. | 2016 | Mol Metab | pmid:27900262 |
Kim HR et al. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. | 2016 | PLoS ONE | pmid:27855185 |
Tombolan L et al. | Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. | 2016 | BMC Cancer | pmid:27842508 |
Tao W et al. | Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. | 2016 | Neuroscience | pmid:27646288 |
Chen W et al. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. | 2016 | Biochim. Biophys. Acta | pmid:27638301 |
Duffy S et al. | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27551064 |
Bauer I et al. | A Class 1 Histone Deacetylase with Potential as an Antifungal Target. | 2016 | MBio | pmid:27803184 |
Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
Nadanaka S et al. | Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751852 |
Tiper IV and Webb TJ | Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. | 2016 | Cancer Immunol. Immunother. | pmid:27614429 |
Morinobu A et al. | Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. | 2016 | PLoS ONE | pmid:27736946 |
Hrgovic I et al. | The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. | 2016 | BMC Cancer | pmid:27716272 |
Sobue S et al. | Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27687545 |
Zhang Q et al. | Trichostatin A protects against intestinal injury in rats with acute liver failure. | 2016 | J. Surg. Res. | pmid:27620992 |
Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
Sugiyama KI et al. | Epigenetic mutagen as histone modulator can be detected by yeast flocculation. | 2016 | Mutagenesis | pmid:27549112 |
Zhang XF et al. | Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. | 2016 | Int J Mol Sci | pmid:27548148 |
Scholpa NE et al. | Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. | 2016 | Chem. Biol. Interact. | pmid:27543423 |
Hou Y et al. | Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. | 2016 | Neurosci Bull | pmid:27522594 |
Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
Wang S et al. | Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. | 2016 | Cytokine | pmid:27500645 |
Li C et al. | PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells. | 2016 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:27451443 |
Igaz N et al. | Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles. | 2016 | Colloids Surf B Biointerfaces | pmid:27434153 |
Qu H et al. | Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. | 2016 | Mol Med Rep | pmid:27431944 |
Choi SY et al. | Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. | 2016 | J. Cell. Mol. Med. | pmid:27420561 |
Dhoke NR et al. | Histone deacetylases differentially regulate the proliferative phenotype of mouse bone marrow stromal and hematopoietic stem/progenitor cells. | 2016 | Stem Cell Res | pmid:27394013 |
Drzewiecka H et al. | Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27393180 |
Zhang NH et al. | Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. | 2016 | Oncol. Rep. | pmid:27373420 |
Chang I and Wang CY | Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. | 2016 | J. Biol. Chem. | pmid:27369083 |
Yagi K et al. | Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. | 2016 | Crit. Care Med. | pmid:27352127 |
Wei L et al. | Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. | 2016 | Brain Res. | pmid:27312092 |
Hakami NY et al. | Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. | 2016 | J. Cell. Mol. Med. | pmid:27297729 |
Raju I et al. | Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. | 2016 | Biol. Chem. | pmid:27279059 |
Somanna NK et al. | Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation. | 2016 | Hypertens. Res. | pmid:27278287 |
Kang HR et al. | Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. | 2016 | Oncol. Rep. | pmid:27277338 |
Agudelo M et al. | Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. | 2016 | PLoS ONE | pmid:27249803 |
Allgayer J et al. | Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. | 2016 | Nucleic Acids Res. | pmid:27220469 |
Du R et al. | Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. | 2016 | Mol Med Rep | pmid:27121018 |
Wang H et al. | [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. | 2016 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:27117217 |
Gehring KB et al. | Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. | 2016 | Learn. Mem. | pmid:27084927 |
Li QQ et al. | Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. | 2016 | Int. J. Oncol. | pmid:27082124 |
Duclot F et al. | Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). | 2016 | Horm Behav | pmid:27074037 |
Toki S et al. | The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. | 2016 | Thorax | pmid:27071418 |
Chen J et al. | Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα. | 2016 | PLoS ONE | pmid:27058040 |
Zhang F et al. | Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. | 2016 | Anal. Chem. | pmid:27046421 |
Huynh NC et al. | Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells. | 2016 | J. Cell. Biochem. | pmid:27043246 |
Gupta DK et al. | DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. | 2016 | Sci Rep | pmid:27033103 |
Clarke CJ et al. | ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. | 2016 | J. Lipid Res. | pmid:27013100 |
Cui W et al. | A SUMO-acetyl switch in PXR biology. | 2016 | Biochim. Biophys. Acta | pmid:26883953 |
Ho TT et al. | Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. | 2016 | Int J Biochem Mol Biol | pmid:27570640 |
Ma X et al. | Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. | 2016 | BMC Genomics | pmid:26847576 |
Li L et al. | Trichostatin A potentiates TRAIL-induced antitumor effects via inhibition of ERK/FOXM1 pathway in gastric cancer. | 2016 | Tumour Biol. | pmid:26831669 |
Rios EC et al. | The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. | 2016 | Life Sci. | pmid:26826317 |
Wang X et al. | The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. | 2016 | In Vitro Cell. Dev. Biol. Anim. | pmid:26822431 |
Kuan CS et al. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. | 2016 | PLoS ONE | pmid:26807725 |
Noh H et al. | Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26768368 |
Hosseini SM et al. | Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. | 2016 | BMC Genomics | pmid:26725231 |
Lee K et al. | Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis. | 2016 | J. Plant Physiol. | pmid:26724747 |
Calvert S et al. | A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. | 2016 | Aging Cell | pmid:26676933 |
Zhang Q et al. | Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins. | 2016 | Mol Med Rep | pmid:26647731 |
Kikuchi M et al. | Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. | 2016 | Oncotarget | pmid:26646320 |
Sheng Y et al. | Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma. | 2016 | Gynecol. Oncol. | pmid:26597461 |
Yeh BW et al. | Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26589485 |
Asgar MA et al. | Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. | 2016 | Int. J. Oncol. | pmid:26575528 |
Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |
Ranganathan P et al. | Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. | 2016 | Kidney Int. | pmid:26509586 |
Selokar NL et al. | Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. | 2016 | Zygote | pmid:26503476 |
Trifunović D et al. | HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. | 2016 | Hum. Mol. Genet. | pmid:28172811 |
Vargas-López V et al. | Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. | 2016 | Neurobiol Learn Mem | pmid:27544851 |
Piao J et al. | Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC. | 2016 | Oncotarget | pmid:27507059 |
Kim HJ et al. | Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. | 2016 | Biotechnol. Lett. | pmid:26341652 |
Meng Z et al. | PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. | 2016 | Oncogene | pmid:26279303 |
Pang X et al. | Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. | 2016 | Tumour Biol. | pmid:26264615 |
Kim SH et al. | The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. | 2016 | Endocrine | pmid:26219406 |
Tan CS et al. | Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. | 2016 | Mol. Neurobiol. | pmid:26162318 |