Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ho WC et al. | Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. | 2005 | Cancer Res. | pmid:15899819 |
Koh SH et al. | Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15752760 |
Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |
Dote H et al. | Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. | 2005 | Br. J. Cancer | pmid:15770214 |
Laberge RM and Boissonneault G | On the nature and origin of DNA strand breaks in elongating spermatids. | 2005 | Biol. Reprod. | pmid:15772260 |
Kawano T et al. | Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect. | 2004 Sep-Oct | Anticancer Res. | pmid:15517875 |
Fenic I et al. | In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. | 2004 Sep-Oct | J. Androl. | pmid:15292114 |
Emionite L et al. | Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines. | 2004 Nov-Dec | Anticancer Res. | pmid:15736447 |
Karasawa Y and Okisaka S | Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells. | 2004 Nov-Dec | Jpn. J. Ophthalmol. | pmid:15592778 |
Hildmann C et al. | A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. | 2004 | J. Bacteriol. | pmid:15060035 |
Vorontsova M et al. | Effect of 5-azacytidine and trichostatin A on somatic centromere association in wheat. | 2004 | Genome | pmid:15060593 |
Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
Kurtev V et al. | Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. | 2004 | J. Biol. Chem. | pmid:15140878 |
Kim YH et al. | Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. | 2004 | Carcinogenesis | pmid:15142888 |
Klampfer L et al. | Requirement of histone deacetylase activity for signaling by STAT1. | 2004 | J. Biol. Chem. | pmid:15123634 |
Fu M et al. | The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. | 2004 | J. Biol. Chem. | pmid:15123687 |
Phan D et al. | Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. | 2004 | Cancer Res. | pmid:15126343 |
Iezzi S et al. | Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. | 2004 | Dev. Cell | pmid:15130492 |
Bort R et al. | Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. | 2004 | Arch. Biochem. Biophys. | pmid:15130783 |
Ishii S et al. | Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone. | 2004 | Mol. Endocrinol. | pmid:15131262 |
Brush MH et al. | Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. | 2004 | J. Biol. Chem. | pmid:14670976 |
Lee JH et al. | Histone deacetylase activity is required for embryonic stem cell differentiation. | 2004 | Genesis | pmid:14755802 |
Lemonde S et al. | Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. | 2004 | J. Neurochem. | pmid:14756806 |
Hattori N et al. | Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. | 2004 | J. Biol. Chem. | pmid:14761969 |
Liu X et al. | Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. | 2004 | Biochem. Pharmacol. | pmid:15041467 |
Christian M et al. | Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. | 2004 | J. Biol. Chem. | pmid:14736873 |
Mai A et al. | 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. | 2004 | J. Med. Chem. | pmid:14971890 |
Nishikawa J et al. | Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line. | 2004 | Virus Genes | pmid:14739656 |
Milhem M et al. | Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. | 2004 | Blood | pmid:14976039 |
Wang DF et al. | QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741273 |
Agostinho M et al. | Human topoisomerase IIalpha: targeting to subchromosomal sites of activity during interphase and mitosis. | 2004 | Mol. Biol. Cell | pmid:14978217 |
Sakata R et al. | Trichostatin A activates the osteopontin gene promoter through AP1 site. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14985105 |
Knobbe CB et al. | Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. | 2004 | J. Natl. Cancer Inst. | pmid:15026474 |
Yan C et al. | A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. | 2004 | FASEB J. | pmid:14715692 |
Chung YL et al. | Antitumor histone deacetylase inhibitors suppress cutaneous radiation syndrome: Implications for increasing therapeutic gain in cancer radiotherapy. | 2004 | Mol. Cancer Ther. | pmid:15026552 |
Steiner E et al. | SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047174 |
Kypreou KP et al. | Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A. | 2004 | Exp. Gerontol. | pmid:15050280 |
Cao H et al. | Induction of human gamma globin gene expression by histone deacetylase inhibitors. | 2004 | Blood | pmid:12920038 |
Sarg B et al. | Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. | 2004 | J. Biol. Chem. | pmid:15456746 |
Nan X et al. | Potent stimulation of gene expression by histone deacetylase inhibitors on transiently transfected DNA. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15465025 |
Lee HS et al. | Gene expression analysis in human gastric cancer cell line treated with trichostatin A and S-adenosyl-L-homocysteine using cDNA microarray. | 2004 | Biol. Pharm. Bull. | pmid:15467184 |
Sangster-Guity N et al. | Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment. | 2004 | Cancer Biol. Ther. | pmid:15467438 |
Alcendor RR et al. | Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. | 2004 | Circ. Res. | pmid:15486319 |
Gius D et al. | Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. | 2004 | Cancer Cell | pmid:15488759 |
De La Fuente R et al. | Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. | 2004 | Dev. Biol. | pmid:15501230 |
Lin AC et al. | The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. | 2004 | J. Biol. Chem. | pmid:15507435 |
Wang S and Zhu J | The hTERT gene is embedded in a nuclease-resistant chromatin domain. | 2004 | J. Biol. Chem. | pmid:15516693 |
Yamashita Y et al. | cDNA microarray analysis in hepatocyte differentiation in Huh 7 cells. | 2004 | Cell Transplant | pmid:15690981 |
GarcÃa I et al. | Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. | 2004 | Eukaryotic Cell | pmid:14871945 |
Takai N et al. | Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. | 2004 | Clin. Cancer Res. | pmid:14871994 |
Ronai D et al. | The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature. | 2004 | Genetics | pmid:15166165 |
Zhang X et al. | Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. | 2004 | Mol. Cell. Biol. | pmid:15169878 |
Ishiguro K and Sartorelli AC | Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | 2004 | Eur. J. Biochem. | pmid:15182353 |
Brieger A et al. | In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors. | 2004 | Biochem. Pharmacol. | pmid:15183120 |
Shim JS et al. | Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. | 2004 | Oncogene | pmid:14661058 |
Tang XX et al. | Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma. | 2004 | Clin. Cancer Res. | pmid:15355914 |
Yokota T et al. | Trichostatin A activates p18INK4c gene: differential activation and cooperation with p19INK4d gene. | 2004 | FEBS Lett. | pmid:15358560 |
Boehrer S et al. | In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis. | 2004 | Leuk. Lymphoma | pmid:15359646 |
Vaghefi H and Neet KE | Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. | 2004 | Oncogene | pmid:15361854 |
Moore PS et al. | Gene expression profiling after treatment with the histone deacetylase inhibitor trichostatin A reveals altered expression of both pro- and anti-apoptotic genes in pancreatic adenocarcinoma cells. | 2004 | Biochim. Biophys. Acta | pmid:15363630 |
Chiba T et al. | Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. | 2004 | J. Hepatol. | pmid:15336447 |
Liu CJ et al. | Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. | 2004 | J. Biol. Chem. | pmid:15337766 |
Cosio BG et al. | Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. | 2004 | J. Exp. Med. | pmid:15337792 |
Iijima K et al. | Granulocytic differentiation of leukemic cells with t(9;11)(p22;q23) induced by all-trans-retinoic acid. | 2004 | Leuk. Lymphoma | pmid:15291362 |
Tóth KF et al. | Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin. | 2004 | J. Cell. Sci. | pmid:15292402 |
Myzak MC et al. | A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. | 2004 | Cancer Res. | pmid:15313918 |
Munro J et al. | Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. | 2004 | Exp. Cell Res. | pmid:15093749 |
Ishihara K et al. | Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils. | 2004 | Br. J. Pharmacol. | pmid:15210580 |
Marengo E et al. | Identification of the regulatory proteins in human pancreatic cancers treated with Trichostatin A by 2D-PAGE maps and multivariate statistical analysis. | 2004 | Anal Bioanal Chem | pmid:15257427 |
Schauber J et al. | Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. | 2004 | Mol. Immunol. | pmid:15261456 |
De La Fuente R et al. | ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. | 2004 | Dev. Biol. | pmid:15242786 |
Fang JY et al. | Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116. | 2004 | Cell Res. | pmid:15225415 |
Banwell CM et al. | Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15225779 |
Mao DY et al. | Promoter-binding and repression of PDGFRB by c-Myc are separable activities. | 2004 | Nucleic Acids Res. | pmid:15226411 |
Naruse Y et al. | Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. | 2004 | Mol. Cell. Biol. | pmid:15226430 |
Alao JP et al. | Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. | 2004 | Clin. Cancer Res. | pmid:15585645 |
Chen WK et al. | [Effect of trichostatin A on histone acetylation level and apoptosis in HL-60 cells]. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15228659 |
Kim JH et al. | Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. | 2004 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:15234053 |
Sakamoto S et al. | Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. | 2004 | J. Biol. Chem. | pmid:15194680 |
Ng Y et al. | Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. | 2004 | J. Biol. Chem. | pmid:15194684 |
Lu H et al. | Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. | 2004 | J. Virol. | pmid:15194748 |