trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Flørenes VA et al. | Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. | 2004 | Melanoma Res. | pmid:15179185 |
| Ahn MR et al. | Trichostatin A, a histone deacetylase inhibitor stimulate CYP3A4 proximal promoter activity in Hepa-I cells. | 2004 | Arch. Pharm. Res. | pmid:15180307 |
| Vanhaecke T et al. | Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. | 2004 | Curr. Med. Chem. | pmid:15180568 |
| Kato N et al. | Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. | 2004 | Cell Death Differ. | pmid:15153943 |
| Ramakrishnan G et al. | Histone acetyltransferases and deacetylase in Entamoeba histolytica. | 2004 | Mol. Biochem. Parasitol. | pmid:15555732 |
| Zoumpoulidou G et al. | Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). | 2004 | Mol. Endocrinol. | pmid:15155784 |
| Wang LG et al. | Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. | 2004 | Oncogene | pmid:15156193 |
| Romanski A et al. | Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. | 2004 | Haematologica | pmid:15075075 |
| Bayart E et al. | A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. | 2004 | Cancer Res. | pmid:15604258 |
| Ahmed S et al. | A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. | 2004 | Mol. Cell. Biol. | pmid:15082762 |
| Amor DJ et al. | Human centromere repositioning "in progress". | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084747 |
| Tani M et al. | Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells. | 2004 | Genes Chromosomes Cancer | pmid:15101048 |
| Lasa A et al. | MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias. | 2004 | Leukemia | pmid:15103390 |
| Yokota T et al. | Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. | 2004 | Oncogene | pmid:15107822 |
| McGarry LC et al. | Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. | 2004 | Oncogene | pmid:15107823 |
| Chen YX et al. | [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. | 2004 | Zhonghua Yi Xue Za Zhi | pmid:15059516 |
| Winn RA and Heasley LE | Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. | 2004 | Chest | pmid:15136458 |
| Jin YH et al. | Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. | 2004 | J. Biol. Chem. | pmid:15138260 |
| Milutinovic S et al. | DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation. | 2004 | J. Biol. Chem. | pmid:15087453 |
| Chang HC et al. | Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. | 2004 | Cell. Signal. | pmid:15093608 |
| Nishino N et al. | Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109626 |
| Marson CM et al. | Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109636 |
| Arapshian A et al. | Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. | 2004 | Mol. Cancer | pmid:15113415 |
| Mizukami T et al. | Effects of trichostatin a, a histone deacetylase inhibitor, on mouse gonadal development in vitro. | 2004 | J. Reprod. Dev. | pmid:15118250 |
| Ganslmayer M et al. | A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. | 2004 | Oncol. Rep. | pmid:15069530 |
| Margueron R et al. | Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. | 2004 | J. Mol. Endocrinol. | pmid:15072561 |
| Reifenberger J et al. | Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. | 2004 | Int. J. Cancer | pmid:14961576 |
| Sugimoto S et al. | Expression and regulation of tumor suppressor gene maspin in human bladder cancer. | 2004 | Cancer Lett. | pmid:14732229 |
| Vaisburg A et al. | (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14684344 |
| Lu XC et al. | [Effect of inhibitors for demethylation and histone deacetylase on proliferation of cell line K562 and expression of tumor related genes]. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:14989767 |
| Nojima H et al. | Increase in DNA methylation downregulates conceptus interferon-tau gene expression. | 2004 | Mol. Reprod. Dev. | pmid:14991730 |
| Leu TH et al. | Participation of p97Eps8 in Src-mediated transformation. | 2004 | J. Biol. Chem. | pmid:14699156 |
| Chua YL et al. | Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. | 2004 | Plant J. | pmid:14996214 |
| Khan AN et al. | An epigenetically altered tumor cell vaccine. | 2004 | Cancer Immunol. Immunother. | pmid:14997346 |
| Pagans S et al. | Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. | 2004 | J. Biol. Chem. | pmid:14701830 |
| Ragno R et al. | 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. | 2004 | J. Med. Chem. | pmid:14998325 |
| Hwang CK et al. | Transcriptional regulation of mouse mu opioid receptor gene by PU.1. | 2004 | J. Biol. Chem. | pmid:14998994 |
| Gray SG et al. | Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. | 2004 | Int. J. Oncol. | pmid:15010814 |
| Koch A et al. | Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12871851 |
| Aapola U et al. | Epigenetic modifications affect Dnmt3L expression. | 2004 | Biochem. J. | pmid:15015937 |
| Burton GR et al. | Microarray analysis of differentiation-specific gene expression during 3T3-L1 adipogenesis. | 2004 | Gene | pmid:15033539 |
| David GL et al. | MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine. | 2004 | Cancer Biol. Ther. | pmid:15034303 |
| Elaut G et al. | Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors. | 2004 | Altern Lab Anim | pmid:23577441 |
| Zelko IN and Folz RJ | Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. | 2004 | Free Radic. Biol. Med. | pmid:15451065 |
| Chiba T et al. | Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. | 2004 | Oncology | pmid:15452378 |
| Jose B et al. | Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15454224 |
| Uramoto H et al. | p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. | 2004 | J. Cell. Sci. | pmid:15454570 |
| El-Khoury V et al. | Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. | 2004 | Cytometry A | pmid:15517561 |
| Vaquero A et al. | Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. | 2004 | Mol. Cell | pmid:15469825 |
| Ladd PD et al. | Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus. | 2004 | Gene | pmid:15474314 |
| Li H and Wu X | Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474507 |
| Spenger A et al. | Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. | 2004 | Protein Expr. Purif. | pmid:15477077 |
| Yee SB et al. | Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. | 2004 | Int. J. Oncol. | pmid:15492835 |
| Young JC et al. | Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. | 2004 | Cytotherapy | pmid:16146885 |
| Um SJ et al. | In vitro antitumor potential of 4-BPRE, a butyryl aminophenyl ester of retinoic acid: role of the butyryl group. | 2004 | Oncol. Rep. | pmid:14767528 |
| Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
| Fan X et al. | Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. | 2004 | J. Cell. Biochem. | pmid:15389882 |
| Astrand C et al. | Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure. | 2004 | Eur. J. Biochem. | pmid:15009194 |
| Chen YX et al. | Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. | 2004 | World J. Gastroenterol. | pmid:15309711 |
| Heltweg B et al. | Subtype selective substrates for histone deacetylases. | 2004 | J. Med. Chem. | pmid:15456267 |
| Alikhani-Koopaei R et al. | Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. | 2004 | J. Clin. Invest. | pmid:15489962 |
| Marsili G et al. | Role of acetylases and deacetylase inhibitors in IRF-1-mediated HIV-1 long terminal repeat transcription. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15659847 |
| Keen JC et al. | Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells. | 2004 | Cancer Biol. Ther. | pmid:15662126 |
| Ding W | [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]. | 2004 | Hokkaido Igaku Zasshi | pmid:15675303 |
| Jang ER et al. | The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. | 2004 | Oncogene | pmid:14676837 |
| Thelen P et al. | Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells. | 2004 | Int. J. Oncol. | pmid:14654937 |
| Zhang Y et al. | Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. | 2004 | Radiat. Res. | pmid:15161353 |
| Glenn MP et al. | Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. | 2004 | J. Med. Chem. | pmid:15163181 |
| Kramps C et al. | E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. | 2004 | J. Biol. Chem. | pmid:14645238 |
| Chaturvedi V et al. | Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. | 2004 | J. Cell. Physiol. | pmid:14584049 |
| Laeng P et al. | The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. | 2004 | J. Neurochem. | pmid:15379904 |
| Kim MK and Carroll WL | Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2. | 2004 | Cancer | pmid:15382088 |
| Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
| Facchetti F et al. | Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. | 2004 | Apoptosis | pmid:15314285 |
| Roh MS et al. | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | 2004 | Apoptosis | pmid:15314286 |
| Yanaihara N et al. | Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. | 2004 | Int. J. Cancer | pmid:15305387 |
| Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
| Schultz BE et al. | Kinetics and comparative reactivity of human class I and class IIb histone deacetylases. | 2004 | Biochemistry | pmid:15323567 |
| Tao D et al. | Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression. | 2004 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:15346199 |
| Korkmaz CG et al. | Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants. | 2004 | J. Endocrinol. | pmid:15350180 |
| Akimoto T | [Potentiation of radiation-induced cell killing by histone deacetylase inhibitor]. | 2004 | Nippon Rinsho | pmid:15283155 |
| Joung KE et al. | Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15283467 |
| Kang J et al. | Synergistic killing of human leukemia cells by antioxidants and trichostatin A. | 2004 | Cancer Chemother. Pharmacol. | pmid:15248029 |
| Jin B and Ryu DY | Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. | 2004 | J. Biochem. Mol. Toxicol. | pmid:15252868 |
| Gilchrist S et al. | Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. | 2004 | Chromosome Res. | pmid:15254368 |
| Aggarwal BD and Calvi BR | Chromatin regulates origin activity in Drosophila follicle cells. | 2004 | Nature | pmid:15254542 |
| Sanderson L et al. | Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. | 2004 | Drug Metab. Dispos. | pmid:15269190 |
| Levenson JM et al. | Regulation of histone acetylation during memory formation in the hippocampus. | 2004 | J. Biol. Chem. | pmid:15273246 |
| Li X et al. | Regulation of histone acetylation and apoptosis by trichostatin in HL-60 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15791844 |
| Liu C and Xu D | Inhibition of histone deacetylases. | 2004 | Methods Mol. Biol. | pmid:15273406 |
| Garfinkel MD et al. | Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila. | 2004 | Methods Mol. Biol. | pmid:15273410 |
| Vanhaecke T et al. | Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. | 2004 | Biochem. Pharmacol. | pmid:15276083 |
| ChuÄkin IA et al. | [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. | 2004 | Tsitologiia | pmid:15747838 |
| Korzus E et al. | CBP histone acetyltransferase activity is a critical component of memory consolidation. | 2004 | Neuron | pmid:15207240 |
| Moldenhauer A et al. | Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. | 2004 | J. Leukoc. Biol. | pmid:15197237 |
| Min KN et al. | Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15202563 |
| Jia S et al. | RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. | 2004 | Science | pmid:15218150 |
| Sumer H et al. | Effects of scaffold/matrix alteration on centromeric function and gene expression. | 2004 | J. Biol. Chem. | pmid:15220334 |
| Lee YJ et al. | Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. | 2004 | Mol. Cells | pmid:15179033 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |