trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ferreira R et al. | Site-specific acetylation of ISWI by GCN5. | 2007 | BMC Mol. Biol. | pmid:17760996 |
| Balaguer TM et al. | Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines. | 2012 | BMC Mol. Biol. | pmid:22846052 |
| Gaviraghi M et al. | Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene. | 2008 | BMC Mol. Biol. | pmid:18549468 |
| Chandler SP et al. | Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect. | 2003 | BMC Mol. Biol. | pmid:12659659 |
| Marshall H et al. | Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice. | 2010 | BMC Mol. Biol. | pmid:20429939 |
| Wu J et al. | Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing. | 2007 | BMC Genomics | pmid:17524140 |
| Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
| Aseem O et al. | Cubilin expression is monoallelic and epigenetically augmented via PPARs. | 2013 | BMC Genomics | pmid:23773363 |
| Ehrenkaufer GM et al. | Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. | 2007 | BMC Genomics | pmid:17612405 |
| Scholl C et al. | Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain. | 2012 | BMC Genomics | pmid:22748179 |
| Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
| Ma X et al. | Identification of genes regulated by histone acetylation during root development in Populus trichocarpa. | 2016 | BMC Genomics | pmid:26847576 |
| Hosseini SM et al. | Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. | 2016 | BMC Genomics | pmid:26725231 |
| Dannenberg LO and Edenberg HJ | Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. | 2006 | BMC Genomics | pmid:16854234 |
| Hedberg Oldfors C et al. | Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. | 2015 | BMC Genet. | pmid:26170120 |
| Lee TB et al. | Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. | 2008 | BMC Gastroenterol | pmid:18673531 |
| Snykers S et al. | Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. | 2007 | BMC Dev. Biol. | pmid:17407549 |
| Kan R et al. | Potential role for PADI-mediated histone citrullination in preimplantation development. | 2012 | BMC Dev. Biol. | pmid:22712504 |
| Chen B and Cepko CL | Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. | 2007 | BMC Dev. Biol. | pmid:17603891 |
| Hou J et al. | Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation. | 2008 | BMC Dev. Biol. | pmid:18507869 |
| Maalouf WE et al. | Trichostatin A treatment of cloned mouse embryos improves constitutive heterochromatin remodeling as well as developmental potential to term. | 2009 | BMC Dev. Biol. | pmid:19210795 |
| Place RF et al. | HDACs and the senescent phenotype of WI-38 cells. | 2005 | BMC Cell Biol. | pmid:16250917 |
| Nordström L et al. | DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. | 2015 | BMC Cancer | pmid:25880212 |
| Mossman D et al. | Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists. | 2010 | BMC Cancer | pmid:20618997 |
| Tong JH et al. | Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. | 2010 | BMC Cancer | pmid:20525238 |
| Moreira JM et al. | The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. | 2003 | BMC Cancer | pmid:14606959 |
| Wu Y et al. | Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. | 2010 | BMC Cancer | pmid:20132554 |
| Acun T et al. | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. | 2011 | BMC Cancer | pmid:21645397 |
| DÃaz-Núñez M et al. | Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. | 2016 | BMC Cancer | pmid:27549189 |
| Mazières J et al. | Epigenetic regulation of RhoB loss of expression in lung cancer. | 2007 | BMC Cancer | pmid:18047684 |
| Arce L et al. | Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. | 2009 | BMC Cancer | pmid:19460168 |
| Tombolan L et al. | Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. | 2016 | BMC Cancer | pmid:27842508 |
| Hrgovic I et al. | The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. | 2016 | BMC Cancer | pmid:27716272 |
| Dávalos-Salas M et al. | Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. | 2011 | BMC Cancer | pmid:21663659 |
| Kim TW et al. | Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. | 2013 | BMC Cancer | pmid:24160266 |
| Zou CF et al. | Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. | 2011 | BMC Cancer | pmid:21244707 |
| Mühlethaler-Mottet A et al. | Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. | 2006 | BMC Cancer | pmid:16930472 |
| Puppin C et al. | HEX expression and localization in normal mammary gland and breast carcinoma. | 2006 | BMC Cancer | pmid:16854221 |
| Viñuelas J et al. | Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts. | 2013 | BMC Biol. | pmid:23442824 |
| Xu ZM et al. | The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage. | 2008 | BMB Rep | pmid:18377727 |
| Chen Z et al. | BCL11A represses HBG transcription in K562 cells. | 2009 Mar-Apr | Blood Cells Mol. Dis. | pmid:19153051 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |
| Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
| Zhou DC et al. | Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. | 2002 | Blood | pmid:11830487 |
| Milhem M et al. | Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. | 2004 | Blood | pmid:14976039 |
| Cao H et al. | Induction of human gamma globin gene expression by histone deacetylase inhibitors. | 2004 | Blood | pmid:12920038 |
| Hebbel RP et al. | The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. | 2010 | Blood | pmid:20053759 |
| Sadoul K et al. | HDAC6 controls the kinetics of platelet activation. | 2012 | Blood | pmid:22955928 |
| Hambach L et al. | Hypomethylating drugs convert HA-1-negative solid tumors into targets for stem cell-based immunotherapy. | 2009 | Blood | pmid:19096014 |
| Petti MC et al. | Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. | 2002 | Blood | pmid:12130525 |
| Araki H et al. | Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. | 2007 | Blood | pmid:17185465 |
| Chaurasia P et al. | Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. | 2011 | Blood | pmid:21355088 |
| Jamaluddin MD et al. | Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. | 2007 | Blood | pmid:17698632 |
| Wang X et al. | Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells. | 2010 | Blood | pmid:20858855 |
| Witt O et al. | Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. | 2003 | Blood | pmid:12393499 |
| Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
| Ishiguro K and Sartorelli AC | Coinduction of embryonic and adult-type globin mRNAs by sodium butyrate and trichostatin A in two murine interleukin-3-dependent bone marrow-derived cell lines. | 1998 | Blood | pmid:9834245 |
| Li X et al. | Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. | 2009 | Blood | pmid:19864643 |
| Gao C et al. | Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. | 2013 | Blood | pmid:23287862 |
| Menegola E et al. | Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity. | 2005 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:16193500 |
| Kalaiarasi A et al. | Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase. | 2018 | Biotechnol. Lett. | pmid:29116558 |
| Liu X et al. | The improvement of adenovirus vector production by increased expression of coxsackie adenovirus receptor. | 2009 | Biotechnol. Lett. | pmid:19330491 |
| Kim HJ et al. | Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. | 2016 | Biotechnol. Lett. | pmid:26341652 |
| Seo H et al. | Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering. | 2007 | Biotechnol. Genet. Eng. Rev. | pmid:18059633 |
| Tobias CA et al. | Improved recombinant retroviral titers utilizing trichostatin A. | 2000 | BioTechniques | pmid:11056820 |
| Giannini G et al. | N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19285395 |
| Lee S et al. | Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17588744 |
| Nishino N et al. | Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109626 |
| Marson CM et al. | Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109636 |
| Vaisburg A et al. | (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14684344 |
| Hoque MA et al. | Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23021104 |
| Krennhrubec K et al. | Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17346959 |
| Rajak H et al. | 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21875796 |
| Vaidya AS et al. | Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. | 2012 | Bioorg. Med. Chem. Lett. | pmid:23010266 |
| Loudni L et al. | Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17624773 |
| Wang DF et al. | QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741273 |
| Hirata Y et al. | Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22321215 |
| Desai D et al. | SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20167479 |
| Jose B et al. | Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15454224 |
| Liao V et al. | Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22932316 |
| Pabba C et al. | Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21109435 |
| Smil DV et al. | Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19111466 |
| Islam NM et al. | Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20045316 |
| Riester D et al. | Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19457659 |
| Gupta PK et al. | Inhibitors selective for HDAC6 in enzymes and cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20947351 |
| Shinji C et al. | Design and synthesis of phthalimide-type histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16137884 |
| Uesato S et al. | Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11992774 |
| Hooven LA et al. | Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713371 |
| Chen B et al. | Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15713393 |
| Yu D et al. | Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21840716 |
| Vasudevan A et al. | Heterocyclic ketones as inhibitors of histone deacetylase. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592473 |
| Choi E et al. | Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21256006 |
| Nakao Y et al. | Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18397826 |
| Mazitschek R et al. | Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18430569 |
| Charrier C et al. | Synthesis of rigid trichostatin A analogs as HDAC inhibitors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16904890 |
| Charrier C et al. | Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17897824 |
| Van Ommeslaeghe K et al. | Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12749885 |
| Suzuki T et al. | Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17257837 |
| Lavoie R et al. | Design and synthesis of a novel class of histone deacetylase inhibitors. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11597413 |
| Fu J et al. | Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase. | 2010 | Bioorg. Med. Chem. | pmid:21067930 |