Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jorgensen JS and Nilson JH | AR suppresses transcription of the alpha glycoprotein hormone subunit gene through protein-protein interactions with cJun and activation transcription factor 2. | 2001 | Mol. Endocrinol. | pmid:11518798 |
Phiel CJ et al. | Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. | 2001 | J. Biol. Chem. | pmid:11473107 |
Klar AJ et al. | A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. | 2001 | Genetics | pmid:11404352 |
Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |
Muth V et al. | Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. | 2001 | EMBO J. | pmid:11250901 |
Steinbac OC et al. | Histone deacetylase activity is required for the induction of the MyoD muscle cell lineage in Xenopus. | 2000 Sep-Oct | Biol. Chem. | pmid:11076034 |
Dressel U et al. | Promoter specific sensitivity to inhibition of histone deacetylases: implications for hormonal gene control, cellular differentiation and cancer. | 2000 Mar-Apr | Anticancer Res. | pmid:10810390 |
Liou JS et al. | Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. | 2000 | J. Biol. Chem. | pmid:10967125 |
Mariadason JM et al. | Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. | 2000 | Cancer Res. | pmid:10969808 |
Gray SG et al. | Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. | 2000 | Int. J. Mol. Med. | pmid:10601571 |
Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
Xiao H et al. | p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor. | 2000 | J. Biol. Chem. | pmid:10625687 |
Avram D et al. | Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. | 2000 | J. Biol. Chem. | pmid:10744719 |
Eickhoff B et al. | Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. | 2000 | Biol. Chem. | pmid:10746741 |
Lee SK et al. | Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. | 2000 | J. Biol. Chem. | pmid:10777532 |
Zhang HS et al. | Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. | 2000 | Cell | pmid:10778858 |
Fu M et al. | p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. | 2000 | J. Biol. Chem. | pmid:10779504 |
Gays F et al. | The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin. | 2000 | J. Immunol. | pmid:10799866 |
McInerney JM et al. | Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. | 2000 | Gene Ther. | pmid:10800088 |
McBlane F and Boyes J | Stimulation of V(D)J recombination by histone acetylation. | 2000 | Curr. Biol. | pmid:10801420 |
Hobbs CA and Gilmour SK | High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. | 2000 | J. Cell. Biochem. | pmid:10760944 |
Yoshida M and Horinouchi S | [Histone deacetylase inhibitors--new anticancer agents?]. | 2000 | Tanpakushitsu Kakusan Koso | pmid:10771678 |
Yu F et al. | Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. | 2000 | Nucleic Acids Res. | pmid:10773092 |
Huang X et al. | Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. | 2000 | Clin. Exp. Metastasis | pmid:11448064 |
Kitamura K et al. | Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. | 2000 | Br. J. Haematol. | pmid:10792271 |
Saleh M et al. | Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. | 2000 | Mol. Cell. Biol. | pmid:11046157 |
Diamond SE and Gutierrez-Hartmann A | The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. | 2000 | J. Biol. Chem. | pmid:10921928 |
Chang LK and Liu ST | Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation. | 2000 | Nucleic Acids Res. | pmid:11024171 |
Andoh A et al. | Modulation of complement component (C3 and factor B) biosynthesis by a histone deacetylase inhibitor in human intestinal epithelial cells. | 2000 | Int. J. Mol. Med. | pmid:10851266 |
Suzuki T et al. | Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. | 2000 | Int. J. Cancer | pmid:11093826 |
Sutcliffe JE et al. | Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription. | 2000 | Mol. Cell. Biol. | pmid:11094071 |
Magner WJ et al. | Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. | 2000 | J. Immunol. | pmid:11120829 |
Damjanovski S et al. | Multiple stage-dependent roles for histone deacetylases during amphibian embryogenesis: implications for the involvement of extracellular matrix remodeling. | 2000 | Int. J. Dev. Biol. | pmid:11128570 |
Liang L et al. | Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis. | 2000 | Int. J. Dev. Biol. | pmid:11128572 |
Gaetano C et al. | Transcriptionally active drugs improve adenovirus vector performance in vitro and in vivo. | 2000 | Gene Ther. | pmid:11083470 |
Maecker HL et al. | p53 promotes selection for Fas-mediated apoptotic resistance. | 2000 | Cancer Res. | pmid:10969818 |
Asoh S et al. | The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. | 2000 | J. Biol. Chem. | pmid:10970895 |
Cong YS and Bacchetti S | Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. | 2000 | J. Biol. Chem. | pmid:10986277 |
Wei LN et al. | Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. | 2000 | J. Biol. Chem. | pmid:11006275 |
Badia E et al. | Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. | 2000 | Cancer Res. | pmid:10945620 |
Siavoshian S et al. | Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. | 2000 | Gut | pmid:10716680 |
Wharton W et al. | Inhibition of mitogenesis in Balb/c-3T3 cells by Trichostatin A. Multiple alterations in the induction and activation of cyclin-cyclin-dependent kinase complexes. | 2000 | J. Biol. Chem. | pmid:10945992 |
Zhou Q et al. | Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. | 2000 | J. Biol. Chem. | pmid:10938272 |
Xu RH et al. | Histone acetylation is a checkpoint in FGF-stimulated mesoderm induction. | 2000 | Dev. Dyn. | pmid:10906781 |
Gray SG et al. | IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. | 2000 | Cytokine | pmid:10880258 |
Su GH et al. | A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. | 2000 | Cancer Res. | pmid:10866300 |
Lin F et al. | Unique anti-activator protein-1 activity of retinoic acid receptor beta. | 2000 | Cancer Res. | pmid:10866321 |
Hemavathy K et al. | Human Slug is a repressor that localizes to sites of active transcription. | 2000 | Mol. Cell. Biol. | pmid:10866665 |
Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
Mao C and Shapiro DJ | A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. | 2000 | Endocrinology | pmid:10875235 |
Clayton AL et al. | Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. | 2000 | EMBO J. | pmid:10899125 |
Kang J et al. | Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. | 2000 | J. Biol. Chem. | pmid:10913161 |
Yu J et al. | Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. | 2000 | Mol. Cell. Biol. | pmid:10713181 |
Adachi N et al. | Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation. | 2000 | Gene | pmid:10713444 |
Shin JY et al. | Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. | 2000 | Cancer Res. | pmid:10667572 |
Stöckel B et al. | Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. | 2000 | Eur. J. Biochem. | pmid:10691972 |
Imai S et al. | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. | 2000 | Nature | pmid:10693811 |
Sirchia SM et al. | Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. | 2000 | Oncogene | pmid:10734315 |
DiRenzo J et al. | BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. | 2000 | Mol. Cell. Biol. | pmid:11003650 |
Hu JF et al. | Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. | 2000 | Endocrinology | pmid:11108251 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
Garrison PM et al. | Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. | 2000 | Arch. Biochem. Biophys. | pmid:10666294 |
Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
Kim YB et al. | Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. | 2000 | J. Antibiot. | pmid:11132966 |
Eickhoff B et al. | Trichostatin A-mediated regulation of gene expression and protein kinase activities: reprogramming tumor cells for ribotoxic stress-induced apoptosis. | 2000 | Biol. Chem. | pmid:11154071 |
Yang X et al. | Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. | 2000 | Cancer Res. | pmid:11156387 |
Nakayama T et al. | Epigenetic regulation of androgen receptor gene expression in human prostate cancers. | 2000 | Lab. Invest. | pmid:11140692 |
Pender SL et al. | Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11052988 |
Tobias CA et al. | Improved recombinant retroviral titers utilizing trichostatin A. | 2000 | BioTechniques | pmid:11056820 |
Fukuda K | Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224675 |
Jung M et al. | Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. | 1999 | J. Med. Chem. | pmid:10579829 |
Chien PY et al. | A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. | 1999 | Mol. Endocrinol. | pmid:10598586 |
Taddei A et al. | Duplication and maintenance of heterochromatin domains. | 1999 | J. Cell Biol. | pmid:10601331 |
Nielsen AL et al. | Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. | 1999 | EMBO J. | pmid:10562550 |
Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |
Marenzi S et al. | Efficiency of expression of transfected genes depends on the cell cycle. | 1999 | Mol. Biol. Rep. | pmid:10634509 |
Gray SG et al. | IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. | 1999 | Exp. Cell Res. | pmid:10585285 |
Saunders N et al. | Histone deacetylase inhibitors as potential anti-skin cancer agents. | 1999 | Cancer Res. | pmid:9927053 |
O'Neill LP et al. | A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation. | 1999 | EMBO J. | pmid:10329635 |
Strouboulis J et al. | Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase. | 1999 | Mol. Cell. Biol. | pmid:10330136 |
Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
Cameron EE et al. | Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. | 1999 | Nat. Genet. | pmid:9916800 |
Kim YB et al. | Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. | 1999 | Oncogene | pmid:10229197 |
Johnson BS et al. | Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation. | 1999 | Mol. Cell. Biol. | pmid:10207061 |
Niki T et al. | A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. | 1999 | Hepatology | pmid:10051490 |
Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
Olsson TG et al. | Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast. | 1999 | Curr. Genet. | pmid:10079326 |
Collas P et al. | Active transgenes in zebrafish are enriched in acetylated histone H4 and dynamically associate with RNA Pol II and splicing complexes. | 1999 | J. Cell. Sci. | pmid:10198286 |
Saito A et al. | A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200307 |
Dang VD et al. | A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast. | 1999 | Mol. Cell. Biol. | pmid:10022921 |
Murphy M et al. | Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. | 1999 | Genes Dev. | pmid:10521394 |
Gobl AE et al. | Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. | 1999 | Biochim. Biophys. Acta | pmid:10500243 |
Suzuki T et al. | Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. | 1999 | J. Med. Chem. | pmid:10425110 |
Tagami T et al. | Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor. | 1999 | J. Biol. Chem. | pmid:10428804 |
Radkov SA et al. | Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription. | 1999 | J. Virol. | pmid:10364319 |
Croft JA et al. | Differences in the localization and morphology of chromosomes in the human nucleus. | 1999 | J. Cell Biol. | pmid:10366586 |
Criqui-Filipe P et al. | Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. | 1999 | EMBO J. | pmid:10369679 |
Zhao W et al. | Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes. | 1999 | J. Virol. | pmid:10233965 |