Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
Li L et al. | In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. | 2016 | PLoS ONE | pmid:26900852 |
Shao A et al. | Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. | 2016 | Mol. Neurobiol. | pmid:25399954 |
Hou X et al. | Histone deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma. | 2016 | Clin Respir J | pmid:25307458 |
Pallocca G et al. | Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. | 2016 | Arch. Toxicol. | pmid:26705709 |
Li X et al. | Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27396813 |
Robert C et al. | Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. | 2016 | Leuk. Res. | pmid:27064363 |
Mohammadi-Bardbori A et al. | Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling. | 2016 | Chem. Biol. Interact. | pmid:27041069 |
Li W et al. | Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1. | 2016 | Chem. Res. Toxicol. | pmid:26991801 |
Wu TC et al. | The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26768552 |
DÃaz-Núñez M et al. | Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. | 2016 | BMC Cancer | pmid:27549189 |
Adachi T et al. | Histone deacetylase inhibitors stimulate the susceptibility of A549Â cells to a plasma-activated medium treatment. | 2016 | Arch. Biochem. Biophys. | pmid:27470189 |
Zhang Q et al. | Trichostatin A protects against intestinal injury in rats with acute liver failure. | 2016 | J. Surg. Res. | pmid:27620992 |
Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
Sugiyama KI et al. | Epigenetic mutagen as histone modulator can be detected by yeast flocculation. | 2016 | Mutagenesis | pmid:27549112 |
Zhang XF et al. | Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. | 2016 | Int J Mol Sci | pmid:27548148 |
Scholpa NE et al. | Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. | 2016 | Chem. Biol. Interact. | pmid:27543423 |
Hou Y et al. | Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. | 2016 | Neurosci Bull | pmid:27522594 |
Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
Wang S et al. | Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. | 2016 | Cytokine | pmid:27500645 |
Por ED et al. | Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. | 2016 | J Ocul Pharmacol Ther | pmid:27494828 |
Liu Y et al. | DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac. | 2016 | J. Exp. Clin. Cancer Res. | pmid:27461117 |
Feng Q et al. | Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation. | 2016 | Int. J. Mol. Med. | pmid:27460781 |
Miyake Y et al. | Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. | 2016 | Nat. Chem. Biol. | pmid:27454931 |
Du R et al. | Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. | 2016 | Mol Med Rep | pmid:27121018 |
Wang H et al. | [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. | 2016 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:27117217 |
Gehring KB et al. | Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. | 2016 | Learn. Mem. | pmid:27084927 |
Li QQ et al. | Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. | 2016 | Int. J. Oncol. | pmid:27082124 |
Duclot F et al. | Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). | 2016 | Horm Behav | pmid:27074037 |
Toki S et al. | The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. | 2016 | Thorax | pmid:27071418 |
Chen J et al. | Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα. | 2016 | PLoS ONE | pmid:27058040 |
Zhang F et al. | Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. | 2016 | Anal. Chem. | pmid:27046421 |
Huynh NC et al. | Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells. | 2016 | J. Cell. Biochem. | pmid:27043246 |
Gupta DK et al. | DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. | 2016 | Sci Rep | pmid:27033103 |
Clarke CJ et al. | ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. | 2016 | J. Lipid Res. | pmid:27013100 |
Zhang HP et al. | Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. | 2016 | Respirology | pmid:26991676 |
Sharma K et al. | Constitutive hyperactivity of histone deacetylases enhances radioresistance in Lepidopteran Sf9 insect cells. | 2016 | Biochim. Biophys. Acta | pmid:26968462 |
Majumdar G and Raghow R | Trichostatin A induces a unique set of microRNAs including miR-129-5p that blocks cyclin-dependent kinase 6 expression and proliferation in H9c2 cardiac myocytes. | 2016 | Mol. Cell. Biochem. | pmid:26946427 |
Sakharkar AJ et al. | A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. | 2016 | Brain Struct Funct | pmid:26941165 |
Ho TT et al. | Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. | 2016 | Int J Biochem Mol Biol | pmid:27570640 |
Deguise MO et al. | Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. | 2016 | Sci Rep | pmid:27349908 |
Sheng Y et al. | Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma. | 2016 | Gynecol. Oncol. | pmid:26597461 |
Yeh BW et al. | Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26589485 |
Asgar MA et al. | Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. | 2016 | Int. J. Oncol. | pmid:26575528 |
Ranganathan P et al. | Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. | 2016 | Kidney Int. | pmid:26509586 |
Selokar NL et al. | Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. | 2016 | Zygote | pmid:26503476 |
Piao J et al. | Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC. | 2016 | Oncotarget | pmid:27507059 |
Kim SH et al. | The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. | 2016 | Endocrine | pmid:26219406 |
Tan CS et al. | Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. | 2016 | Mol. Neurobiol. | pmid:26162318 |