trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chawalit S et al. | Trichostatin A and ascorbic acid assist in the development of porcine handmade cloned embryos via different physiologic pathways. | 2012 | Reprod Sci | pmid:22534331 |
| Liu W et al. | HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. | 2012 | PLoS ONE | pmid:23152903 |
| Lopez-Atalaya JP et al. | Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome. | 2012 | J. Med. Genet. | pmid:21984751 |
| Li Y et al. | Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing family tumors. | 2012 | Cancer Lett. | pmid:22266186 |
| Kan R et al. | Potential role for PADI-mediated histone citrullination in preimplantation development. | 2012 | BMC Dev. Biol. | pmid:22712504 |
| To SQ et al. | Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22929011 |
| Liao V et al. | Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22932316 |
| Agudelo M et al. | Alcohol-induced serotonergic modulation: the role of histone deacetylases. | 2012 | Alcohol | pmid:22796363 |
| Tong K et al. | Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. | 2012 | Eukaryotic Cell | pmid:22771823 |
| Bar-Nur O et al. | Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives. | 2012 | J Mol Cell Biol | pmid:22430918 |
| Kraus J | Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22823387 |
| Qiao F et al. | Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells. | 2012 | Oncol. Rep. | pmid:22825043 |
| Mehdi O et al. | HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). | 2012 Mar-Apr | Pancreatology | pmid:22487525 |
| Guo X et al. | Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. | 2012 May-Jun | Cell. Immunol. | pmid:22776176 |
| Hou W et al. | Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. | 2012 Nov-Dec | J. Androl. | pmid:22556385 |
| Darlyuk-Saadon I et al. | The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22989952 |
| Tang X et al. | Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. | 2012-2013 | Cancer Biomark | pmid:23321465 |
| Lakshmi SV et al. | Oxidative stress in coronary artery disease: epigenetic perspective. | 2013 | Mol. Cell. Biochem. | pmid:23160801 |
| Jackson MF et al. | Genetic manipulation of myoblasts and a novel primary myosatellite cell culture system: comparing and optimizing approaches. | 2013 | FEBS J. | pmid:23173931 |
| Bianco C et al. | Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23129342 |
| Carbajal A et al. | A novel method for purification of polymerizable tubulin with a high content of the acetylated isotype. | 2013 | Biochem. J. | pmid:23140207 |
| Pelascini LP et al. | Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. | 2013 | Hum. Gene Ther. | pmid:23140481 |
| Brown CO et al. | Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma. | 2013 | Leuk. Res. | pmid:23537707 |
| Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
| Yacqub-Usman K et al. | Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. | 2013 | Endocrinology | pmid:23539512 |
| Khan DH and Davie JR | HDAC inhibitors prevent the induction of the immediate-early gene FOSL1, but do not alter the nucleosome response. | 2013 | FEBS Lett. | pmid:23542037 |
| Humphreys KJ et al. | Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. | 2013 | Mol. Carcinog. | pmid:22308110 |
| Tigges J et al. | Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. | 2013 | J. Invest. Dermatol. | pmid:22951721 |
| Doñas C et al. | Trichostatin A promotes the generation and suppressive functions of regulatory T cells. | 2013 | Clin. Dev. Immunol. | pmid:23737814 |
| Flight MH | Behaviour: epigenetically bonded. | 2013 | Nat. Rev. Neurosci. | pmid:23756635 |
| Zhao TC et al. | HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. | 2013 | PLoS ONE | pmid:23762381 |
| Saha A et al. | Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity. | 2013 | Bioorg. Med. Chem. | pmid:23719282 |
| Moldrich RX et al. | Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. | 2013 | Behav. Brain Res. | pmid:24103642 |
| Yamamura A et al. | Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24134849 |
| Xu M et al. | Histone deacetylase inhibitors induce human renal cell carcinoma cell apoptosis through p-JNK activation. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144737 |
| Peng L et al. | [Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro]. | 2013 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:24144739 |
| Wang X et al. | Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. | 2013 | Mol. Carcinog. | pmid:22121107 |
| Sharma A et al. | Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. | 2013 | Carcinogenesis | pmid:23880304 |
| Li Y et al. | Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. | 2013 | Mol. Cancer | pmid:23379261 |
| Jiao F et al. | Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. | 2013 | Stem Cells Dev. | pmid:23750509 |
| Hu X et al. | Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner. | 2013 | Stem Cells Dev. | pmid:22873791 |
| Liu Y et al. | Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development. | 2013 | PLoS ONE | pmid:24223801 |
| Munro SK et al. | Histone deacetylase inhibition by trichostatin A mitigates LPS induced TNFα and IL-10 production in human placental explants. | 2013 | Placenta | pmid:23623485 |
| Hayakawa K et al. | Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells. | 2013 | J. Biol. Chem. | pmid:23625921 |
| Neumann F et al. | EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors. | 2013 | Cancer Immunol. Immunother. | pmid:23619976 |
| Yang H et al. | Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. | 2013 | Biochem. Pharmacol. | pmid:23643933 |
| Majumder A et al. | Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors. | 2013 | Stem Cell Res | pmid:23644509 |
| Nakazawa Y et al. | Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes. | 2013 | J. Immunother. | pmid:23211626 |
| Koch M et al. | Overcoming chemotherapy resistance of ovarian cancer cells by liposomal cisplatin: molecular mechanisms unveiled by gene expression profiling. | 2013 | Biochem. Pharmacol. | pmid:23396090 |
| Iwashita J et al. | Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes. | 2013 | Dev. Growth Differ. | pmid:23346879 |