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Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. |
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Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. |
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NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. |
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Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. |
2006 |
Gastroenterology |
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Deacetylase inhibitors aid recovery in muscular dystrophy. |
2006 |
Lancet Neurol |
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Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. |
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Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. |
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Mol. Cell. Probes |
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Mol. Cell |
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Invest. Ophthalmol. Vis. Sci. |
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Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. |
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Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. |
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NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. |
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Prostate |
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MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. |
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Int. J. Cancer |
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Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. |
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Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. |
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Mol. Cell. Biochem. |
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Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. |
2006 |
Circulation |
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Alcohol. Clin. Exp. Res. |
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Mol. Biol. Cell |
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Exp. Cell Res. |
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2006 |
Cancer Res. |
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Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. |
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Mol. Cell. Biol. |
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Identification of novel target genes by an epigenetic reactivation screen of renal cancer. |
2006 |
Cancer Res. |
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Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. |
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Int. J. Cancer |
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Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. |
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Mol. Endocrinol. |
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Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. |
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5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. |
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Leuk. Res. |
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Mol. Ther. |
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Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. |
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Mol. Endocrinol. |
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Arterioscler. Thromb. Vasc. Biol. |
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Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. |
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Cloning Stem Cells |
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[Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. |
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Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. |
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Endocr. Relat. Cancer |
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Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. |
2006 |
Mol. Hum. Reprod. |
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Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. |
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Pharmazie |
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A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. |
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BMC Cancer |
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Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. |
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Cancer Res. |
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Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. |
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Protist |
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MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Regulation of the prepronociceptin gene and its effect on neuronal differentiation. |
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Gene |
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An ex vivo method for rapid generation of monoclonal antibodies (ADLib system). |
2006 |
Nat Protoc |
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Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. |
2006 |
Cancer Chemother. Pharmacol. |
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Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. |
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Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. |
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Clin. Gastroenterol. Hepatol. |
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Tumor suppressor p53 regulates heparanase gene expression. |
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Oncogene |
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Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. |
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Biochim. Biophys. Acta |
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Trichostatin A induces myocardial differentiation of monkey ES cells. |
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Biochem. Biophys. Res. Commun. |
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Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. |
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J. Reprod. Dev. |
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Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. |
2007 |
Proteomics |
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Histone H2A mobility is regulated by its tails and acetylation of core histone tails. |
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Biochem. Biophys. Res. Commun. |
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Identification of epigenetically silenced genes in tumor endothelial cells. |
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Cancer Res. |
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The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. |
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Genes Cells |
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Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. |
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J. Cell Biol. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. |
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J. Gen. Virol. |
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Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. |
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J. Cell. Physiol. |
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Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. |
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Cancer Lett. |
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The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. |
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Cancer Genet. Cytogenet. |
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Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. |
2007 |
Biol. Reprod. |
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Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. |
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Mol. Cancer Ther. |
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A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. |
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Gastroenterology |
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Deacetylase inhibition promotes the generation and function of regulatory T cells. |
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Nat. Med. |
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[The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. |
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J. Virol. |
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The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60. |
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Biochim. Biophys. Acta |
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Enhancing the anti-angiogenic action of histone deacetylase inhibitors. |
2007 |
Mol. Cancer |
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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. |
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Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. |
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Biochem. Biophys. Res. Commun. |
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