trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Lupus Vulgaris D008177 1 associated lipids
Rubinstein-Taybi Syndrome D012415 1 associated lipids
Goldenhar Syndrome D006053 1 associated lipids
Classical Lissencephalies and Subcortical Band Heterotopias D054221 1 associated lipids
Capsule Opacification D058442 1 associated lipids
Adenomyosis D062788 1 associated lipids
Neoplasm Micrometastasis D061206 1 associated lipids
Cystadenoma, Serous D018293 1 associated lipids
Supratentorial Neoplasms D015173 1 associated lipids
von Hippel-Lindau Disease D006623 1 associated lipids
Intervertebral Disc Degeneration D055959 1 associated lipids
Hypesthesia D006987 1 associated lipids
Cystadenocarcinoma, Mucinous D018282 1 associated lipids
Myopathy, Central Core D020512 1 associated lipids
Roseolovirus Infections D019349 1 associated lipids
Chromosome Inversion D007446 1 associated lipids
Thyroid Hormone Resistance Syndrome D018382 1 associated lipids
Rhabdomyosarcoma, Embryonal D018233 1 associated lipids
Gestational Trophoblastic Disease D031901 1 associated lipids
Carcinoma, Papillary, Follicular D018265 1 associated lipids
Rhabdoid Tumor D018335 1 associated lipids
Visceral Pain D059265 1 associated lipids
Bone Marrow Neoplasms D019046 2 associated lipids
Adenocarcinoma, Papillary D000231 2 associated lipids
Inflammatory Breast Neoplasms D058922 2 associated lipids
Ganglioneuroma D005729 2 associated lipids
Fibromatosis, Aggressive D018222 2 associated lipids
Cystadenocarcinoma, Serous D018284 2 associated lipids
Rhabdomyosarcoma, Alveolar D018232 2 associated lipids
Small Cell Lung Carcinoma D055752 2 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
Mastocytoma D034801 3 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Osteomalacia D010018 5 associated lipids
Carcinoma, Pancreatic Ductal D021441 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Mukhopadhyay NK et al. Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. 2006 Ann. Thorac. Surg. pmid:16488717
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Song YF et al. High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. 2006 J. Clin. Pathol. pmid:16489177
Rokhlin OW et al. Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. 2006 Mol. Cancer Res. pmid:16513842
Lee KY et al. NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. 2006 J. Immunol. pmid:16365456
Hansen KR et al. Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. 2006 Nucleic Acids Res. pmid:16407326
Dowdy SC et al. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. 2006 Mol. Cancer Ther. pmid:17121923
Fischer S et al. Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. 2006 Hum. Mol. Genet. pmid:16407370
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Williams SA et al. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. 2006 EMBO J. pmid:16319923
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Zou B et al. Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. 2006 Gastroenterology pmid:17087954
Anderson I Deacetylase inhibitors aid recovery in muscular dystrophy. 2006 Lancet Neurol pmid:17089447
Kiefer J et al. Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. 2006 Br. J. Nutr. pmid:17092367
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Mogal A and Abdulkadir SA Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. 2006 Mol. Cell. Probes pmid:16326072
Trapp J et al. Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. 2006 J. Med. Chem. pmid:17149860
Pavan Kumar P et al. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. 2006 Mol. Cell pmid:16630892
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Gastaldi T et al. Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. 2006 Carcinogenesis pmid:16537559
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Wallace DM et al. Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16799012
Pampalakis G and Sotiropoulou G Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. 2006 Biol. Chem. pmid:16800739
Wang Y et al. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. 2006 Arthritis Rheum. pmid:16802366
Morinobu A et al. Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. 2006 J. Rheumatol. pmid:16755652
Armstrong K et al. NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. 2006 Prostate pmid:16683270
Wischnewski F et al. Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. 2006 Mol. Cancer Res. pmid:16687489
Yamada N et al. MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. 2006 Int. J. Cancer pmid:16721789
Kim Y et al. Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. 2006 J. Steroid Biochem. Mol. Biol. pmid:16723222
Santander VS et al. Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. 2006 Mol. Cell. Biochem. pmid:16733802
Kong Y et al. Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. 2006 Circulation pmid:16735673
Dannenberg LO et al. Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. 2006 Alcohol. Clin. Exp. Res. pmid:16737450
Cabrero JR et al. Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. 2006 Mol. Biol. Cell pmid:16738306
Vulcano F et al. HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. 2006 Exp. Cell Res. pmid:16739251
Qi H and Ratnam M Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. 2006 Cancer Res. pmid:16740727
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Ibanez de Caceres I et al. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. 2006 Cancer Res. pmid:16707423
Hirsch CL et al. Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. 2006 Int. J. Cancer pmid:16094635
Kim MY et al. Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. 2006 Mol. Endocrinol. pmid:16497729
Leng Y and Chuang DM Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. 2006 J. Neurosci. pmid:16837598
Scott SA et al. 5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. 2006 Leuk. Res. pmid:16043219
Hofmann A et al. Epigenetic regulation of lentiviral transgene vectors in a large animal model. 2006 Mol. Ther. pmid:16140581
Clem BF and Clark BJ Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. 2006 Mol. Endocrinol. pmid:16109738
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Yao J et al. NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. 2006 Pharmacol. Res. pmid:17005413
Inoue K et al. Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:17008592
Baqir S and Smith LC Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. 2006 Cloning Stem Cells pmid:17009896
Hong ZY et al. [Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. 2006 Ai Zheng pmid:16965673
Banwell CM et al. Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. 2006 Clin. Cancer Res. pmid:16609009
Claus R et al. Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. 2006 J. Leukoc. Biol. pmid:17000900
Kogai T et al. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. 2006 Endocr. Relat. Cancer pmid:16954431
Tyson-Capper AJ et al. Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. 2006 Mol. Hum. Reprod. pmid:16959971
Chen J et al. Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. 2006 Pharmazie pmid:16964716
Kim MY et al. A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16924111
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Kimura N et al. Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. 2006 Protist pmid:16839811
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Fandy TE and Srivastava RK Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. 2006 Cancer Chemother. Pharmacol. pmid:16435155
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Gialitakis M et al. Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. 2006 Nucleic Acids Res. pmid:16452299
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Zhou X et al. The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. 2007 Cancer Genet. Cytogenet. pmid:17693185
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Li T and Chiang JY A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. 2007 Gastroenterology pmid:17920062
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Qi J et al. [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. 2007 Zhonghua Yi Xue Za Zhi pmid:17923031
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Hashii M et al. Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. 2007 Biochem. Biophys. Res. Commun. pmid:17367762